TINF2 / TIN2 antibody

Principal name

TINF2 / TIN2 antibody

Alternative names for TINF2 / TIN2 antibody

TERF1-interacting nuclear factor 2, TRF1-interacting nuclear protein 2

SwissProt ID

Q9BSI4 (Human), Q9QXG9 (Mouse)

Gene ID

26277 (TINF2)

Available reactivities

Hu (Human), Bov (Bovine), Ms (Mouse), Mky (Monkey), Prim (Primate), Can (Canine), Eq (Equine), GP (Guinea Pig), Por (Porcine)

Available hosts

Mouse, Rabbit, Goat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P)

Background of TINF2 / TIN2 antibody

TRF1 is a negative regulator of telomere length maintence. Recently two proteins, tankyrase and Tin2, which bind to mammalian TRF1, have been identified. Tankyrase is a protein with homology to ankyrins as well as to the catalytic domain of poly (adenosine diphosphate-ribose) polymerase (PARP). Tankyrase localizes to telomeres by binding to the telomeric repeat binding factor 1 (TRF1) through its ankyrin repeats. Tankyrase exhibits PARP activity functioning as acceptors for adenosine diphosphate (ADP)-ribosylation. Since ADP-ribosylation of TRF1 diminishes its ability to bind to telomeric D, this suggests that telomere function in human cells is regulated by poly (ADP)-ribosylation. Both the cell cycle and TRF1 may regulate the subcellular localization of tankyrase. The cD coding for TIN2 protein was isolated as interacting partner of TRF1 from a yeast two-hybrid cD library screening. Tin2 localizes to telomeres and is essential for proper regulation of telomere length. TIN2, like TRF1, is widely and constitutively expressed, suggesting that these proteins act together to counterbalance telomere elongation by telomerase. However, endogenous TIN2, like endogenous TRF1, is not highly expressed, and therefore may be difficult to visualize by immunostaining in certain cell systems.

General readings

Kim,S.H., (2008) J. Cell Biol. 181 (3), 447-460

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

TINF2 / TIN2 antibody

Western blot analysis of extracts from HUVEC cells, using TINF2 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TINF2 / TIN2 antibody

Western Blot: TIN2 Antibody (59B388.1) [TA336676] - Analysis of Tin2 using Tin2 monoclonal antibody 59B388.1. Human Daudi (A) and mouse NIH 3T3 lysate probed using Tin2 antibody at 2 ug/ml. Mouse IgG1 59B388.1 Purified Hu, Ms WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

TINF2 / TIN2 antibody

WB Suggested Anti-TINF2 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:1562500; Positive Control: MCF7 cell lysateTINF2 is supported by BioGPS gene expression data to be expressed in MCF7 Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por WB
50 µg / €325.00
  OriGene Technologies, Inc.

TINF2 / TIN2 antibody

Western blot analysis on HuvEc cell lysate using TINF2 Antibody Rabbit IgG Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

TINF2 / TIN2 antibody

Western blot (WB) analysis of TIN2 antibody (Cat.-No.: AP06752PU-N) in extracts from HUVEC cells. Rabbit Aff - Purified Hu WB
0.1 mg / €350.00
  Acris Antibodies GmbH

TINF2 / TIN2 (341-354) antibody

Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE) Goat IgG Aff - Purified Hu, Mky, Prim P
50 µg / €470.00
  Acris Antibodies GmbH

TINF2 / TIN2 antibody

TINF2 / TIN2 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

TINF2 / TIN2 antibody

Immunofluorescence of purified MaxPab antibody to TINF2 on HeLa cell. [antibody concentration 10 ug/ml] Mouse Purified Hu E(detection), ICC/IF, WB
50 µg / €370.00
  Abnova Taiwan Corp.

TINF2 / TIN2 antibody

TINF2 / TIN2 Mouse IgG2b 3G11 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

TINF2 / TIN2 antibody

Western blot analysis of TINF2 in Daudi cell lysate. Using TINF2 monoclonal antibody, clone 59B388.1 ( Cat # MAB0084 ) at 2 µg/ml. Mouse IgG1 59B388.1 Hu WB
0.1 mg / €470.00
  Abnova Taiwan Corp.

TINF2 / TIN2 antibody

Western blot analysis of extracts from HuvEc cells, using TINF2 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, WB
50 µg / €205.00
  Assay Biotech

TINF2 / TIN2 antibody

Western blot analysis of extracts from HuvEc cells, using TINF2 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, WB
0.1 mg / €310.00
  Assay Biotech

TINF2 / TIN2 antibody

Human MCF7; Host: Rabbit .  Target Name: TINF2 .  Sample Tissue: MCF7 . Antibody Dilution: 1.0ug/ml. TINF2 is supported by BioGPS gene expression data to be expressed in MCF7.; TINF2 antibody - middle region (ARP58338_P050) in Human MCF7 cells using Western Blot Rabbit Aff - Purified Bov, Hu, Ms WB
50 µg / €350.00
  AVIVA Systems Biology

TINF2 / TIN2 antibody

Immunohistochemical analysis of TIN2 staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Hu P, WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

TINF2 / TIN2 antibody

Immunohistochemical analysis of TIN2 staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Hu P, WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

TINF2 / TIN2 antibody

Immunohistochemical analysis of TIN2 staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Hu P, WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

TINF2 / TIN2

TINF2 / TIN2 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

TINF2 / TIN2

TINF2 / TIN2 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

TINF2 293T Cell Transient Overexpression Lysate(Denatured)

TINF2 293T Cell Transient Overexpression Lysate(Denatured)  
0.1 ml / €270.00
  Abnova Taiwan Corp.

TINF2 overexpression lysate

TINF2 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

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