TINF2 / TIN2 antibody

Principal name

TINF2 / TIN2 antibody

Alternative names for TINF2 / TIN2 antibody

TERF1-interacting nuclear factor 2, TRF1-interacting nuclear protein 2

SwissProt ID

Q9BSI4 (Human), Q9QXG9 (Mouse)

Gene ID

26277 (TINF2)

Available reactivities

Hu (Human), Bov (Bovine), Ms (Mouse), Mky (Monkey), Prim (Primate), Can (Canine), Eq (Equine), GP (Guinea Pig), Por (Porcine)

Available hosts

Mouse, Rabbit, Goat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P)

Background of TINF2 / TIN2 antibody

TRF1 is a negative regulator of telomere length maintence. Recently two proteins, tankyrase and Tin2, which bind to mammalian TRF1, have been identified. Tankyrase is a protein with homology to ankyrins as well as to the catalytic domain of poly (adenosine diphosphate-ribose) polymerase (PARP). Tankyrase localizes to telomeres by binding to the telomeric repeat binding factor 1 (TRF1) through its ankyrin repeats. Tankyrase exhibits PARP activity functioning as acceptors for adenosine diphosphate (ADP)-ribosylation. Since ADP-ribosylation of TRF1 diminishes its ability to bind to telomeric D, this suggests that telomere function in human cells is regulated by poly (ADP)-ribosylation. Both the cell cycle and TRF1 may regulate the subcellular localization of tankyrase. The cD coding for TIN2 protein was isolated as interacting partner of TRF1 from a yeast two-hybrid cD library screening. Tin2 localizes to telomeres and is essential for proper regulation of telomere length. TIN2, like TRF1, is widely and constitutively expressed, suggesting that these proteins act together to counterbalance telomere elongation by telomerase. However, endogenous TIN2, like endogenous TRF1, is not highly expressed, and therefore may be difficult to visualize by immunostaining in certain cell systems.

General readings

Kim,S.H., (2008) J. Cell Biol. 181 (3), 447-460

17 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

TINF2 / TIN2 antibody

  Rabbit polyclonal anti-TINF2 antibody  
Western blot analysis of extracts from HUVEC cells, using TINF2 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TINF2 / TIN2 antibody

  Mouse Monoclonal TIN2 Antibody (59B388.1)  
Western Blot: TIN2 Antibody (59B388.1) [TA336676] - Analysis of Tin2 using Tin2 monoclonal antibody 59B388.1. Human Daudi (A) and mouse NIH 3T3 lysate probed using Tin2 antibody at 2 ug/ml. Mouse IgG1 59B388.1 Purified Hu, Ms WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

TINF2 / TIN2 antibody

  Rabbit Polyclonal Anti-TINF2 Antibody - middle region  
WB Suggested Anti-TINF2 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:1562500; Positive Control: MCF7 cell lysateTINF2 is supported by BioGPS gene expression data to be expressed in MCF7 Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por WB
50 µg / €325.00
  OriGene Technologies, Inc.

TINF2 / TIN2 antibody

  Rabbit Polyclonal Anti-TINF2 Antibody  
Western blot analysis on HuvEc cell lysate using TINF2 Antibody Rabbit IgG Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

TINF2 / TIN2 antibody

Western blot (WB) analysis of TIN2 antibody (Cat.-No.: AP06752PU-N) in extracts from HUVEC cells. Rabbit Aff - Purified Hu WB
0.1 mg / €350.00
  Acris Antibodies GmbH

TINF2 / TIN2 (341-354) antibody

Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE) Goat IgG Aff - Purified Hu, Mky, Prim P
50 µg / €470.00
  Acris Antibodies GmbH

TINF2 / TIN2 antibody

Western blot analysis of extracts from HuvEc cells, using TINF2 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, WB
50 µg / €230.00
  Assay Biotech

TINF2 / TIN2 antibody

Western blot analysis of extracts from HuvEc cells, using TINF2 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, WB
0.1 mg / €330.00
  Assay Biotech

CRISPR

Catalog No. Species Donor Vector  

TINF2 - human gene knockout kit via CRISPR

TINF2 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

TINF2 - human gene knockout kit via CRISPR

TINF2 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

TINF2 - human gene knockout kit via CRISPR

TINF2 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

TINF2 - human gene knockout kit via CRISPR

TINF2 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

TINF2 overexpression lysate

TINF2 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, TINF2 (mGFP-tagged)-Human TERF1 (TRF1)-interacting nuclear factor 2 (TINF2), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, TINF2 (mGFP-tagged)-Human TERF1 (TRF1)-interacting nuclear factor 2 (TINF2), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, TINF2 (mGFP-tagged) - Human TERF1 (TRF1)-interacting nuclear factor 2 (TINF2), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, TINF2 (mGFP-tagged) - Human TERF1 (TRF1)-interacting nuclear factor 2 (TINF2), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €920.00
  OriGene Technologies, Inc.

Lenti ORF particles, TINF2 (Myc-DDK-tagged)-Human TERF1 (TRF1)-interacting nuclear factor 2 (TINF2), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, TINF2 (Myc-DDK-tagged)-Human TERF1 (TRF1)-interacting nuclear factor 2 (TINF2), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

Lenti ORF particles, TINF2 (Myc-DDK tagged) - Human TERF1 (TRF1)-interacting nuclear factor 2 (TINF2), transcript variant 2 , 200 uL, >10^7 TU/mL

Lenti ORF particles, TINF2 (Myc-DDK tagged) - Human TERF1 (TRF1)-interacting nuclear factor 2 (TINF2), transcript variant 2 , 200 uL, >10^7 TU/mL  
200 µl / €820.00
  OriGene Technologies, Inc.

17 Item(s)

per page
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