TIRAP antibody

Principal name

TIRAP antibody

Alternative names for TIRAP antibody

MAL, Toll/interleukin-1 receptor domain-containing adapter protein, TIR domain-containing adapter protein, MyD88 adapter-like protein, Adaptor protein Wyatt

SwissProt ID

P58753 (Human), Q99JY1 (Mouse)

Gene ID

114609 (TIRAP), 117149 (Tirap)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit)

Available hosts

Rabbit, Mouse, Goat, Rat

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Enzyme Immunoassay (E), Frozen Sections (C), Immunoprecipitation (IP)

Background of TIRAP antibody

Mammalian Toll-like receptors (TLRs) recognize conserved products of microbial metabolism and activate NF-kappa B and other signaling pathways through the adapter protein MyD88. All TLRs have a Toll/IL-1 receptor (TIR) domain, which is responsible for signal transduction. MyD88 is one such protein that contains a TIR domain. It acts as an adapter, being involved in TLR-2, TLR-4 and TLR-9 signaling. Toll-interleukin 1 receptor (TIR) domain-containing adapter protein (TIRAP) controls activation of MyD88-independent signaling pathways downstream of TLR4. Double-stranded RNA-binding protein kinase PKR is a component of both the TIRAP- and MyD88-dependent signaling pathways (1). It has been demonstrated that TRIF associates with TRAF6 and TBK1 independently, and activates two distinct transcription factors, NF- B and IFN regulatory factor-3, respectively (2). TIRAP is differentially involved in signaling by members of the TLR family and may account for specificity in the downstream signaling of individual TLRs (3).

General readings

Andreakos E, Sacre SM, Smith C, Lundberg A, Kiriakidis S, Stonehouse T, Monaco C, Feldmann M, Foxwell BM.
Distinct pathways of LPS-induced NF-kappa B activation and cytokine production in human myeloid and nonmyeloid cells defined by selective utilization of MyD88 and Mal/TIRAP.
Blood. 2004 Mar 15;103(6):2229-37.
PMID: 14630816

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

TIRAP (C-term) antibody

TA302730 (1µg/ml) staining of Human Liver lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

TIRAP antibody

TA303067 (0.1µg/ml) staining of K562 cell lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

TIRAP (Center) antibody

Western blot analysis of TIRAP in MCF-7 cell lysate with TIRAP antibody at 4 ug/ml. Rabbit IgG Purified Hu E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

TIRAP (C-term) antibody

Western blot analysis of TIRAP in human heart cell lysates with TIRAP antibody at (A) 0.5, (B) 1, and (C) 2 ug/ml. Rabbit IgG Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

TIRAP antibody

Western Blot: TIRAP (TLR2 and TLR4) Antibody (20D1055.1) [TA336468] - analysis of TIRAP in human spleen lysate using this antibody. Mouse IgM 20D1055.1 Purified Hu WB
0.2 ml / €325.00
  OriGene Technologies, Inc.

TIRAP antibody

WB Suggested Anti-TIRAP Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 312500; Positive Control: Human Placenta Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

TIRAP (C-term) antibody

Western blot analysis of TIRAP in human heart cell lysates with TIRAP antibody at (A) 0.5, (B) 1, and (C) 2 µg/ml. Rabbit IgG Purified Hu, Ms, Rt C, WB
0.1 mg / €370.00
  Acris Antibodies GmbH

TIRAP antibody

Western blot analysis of TIRAP in MCF-7 cell lysate with TIRAP antibody (IN) at 4 µg/ml. Rabbit IgG Purified Hu WB
0.1 mg / €370.00
  Acris Antibodies GmbH

TIRAP antibody

Immunohistochemical staining of human heart with Rabbit anti Mouse TIRAP antibody Cat.-No AP05881PU-N Rabbit IgG Purified Hu, Ms, Rt P, WB
50 µg / €270.00
  Acris Antibodies GmbH

TIRAP antibody

Kidney: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit Purified Hu, Ms, Rt P, WB
50 µg / €470.00
  Acris Antibodies GmbH

TIRAP antibody

Spleen: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit Purified Hu P, WB
50 µg / €470.00
  Acris Antibodies GmbH

TIRAP (N-term) antibody

Skeletal muscle: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit IgG Aff - Purified Hu E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

TIRAP Control Peptide

TIRAP
50 µg / €160.00
  Acris Antibodies GmbH

TIRAP Control Peptide

TIRAP
50 µg / €160.00
  Acris Antibodies GmbH

TIRAP antibody

Immunohistochemical staining of human heart with Rabbit anti Mouse TIRAP antibody Cat.-No AP05881PU-N Rabbit IgG Purified Hu, Ms, Rt P, WB
0.1 mg / €330.00
  Acris Antibodies GmbH

TIRAP antibody

Western Blot analysis of TIRAP expression in transfected 293T cell line (H00114609-T01) by TIRAP MaxPab polyclonal antibody.

Lane 1: TIRAP transfected lysate(28.27 KDa).
Lane 2: Non-transfected lysate. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

TIRAP antibody

TIRAP Rabbit Serum Hu E(detection), IP, WB
0.1 ml / €380.00
  Abnova Taiwan Corp.

TIRAP antibody

TIRAP Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

TIRAP antibody

Western blot analysis of TIRAP. Using TIRAP monoclonal antibody, clone 20D1960.2.1 ( Cat # MAB0073 ) at 1 : 1000 on 20 µgs of human spleen lysate. Mouse IgM 20D1960.2.1 Hu WB
0.2 ml / €470.00
  Abnova Taiwan Corp.

TIRAP antibody

TIRAP Rat IgG2a Sebi-1 Purified Hu IP, WB
0.1 mg / €640.00
  Abnova Taiwan Corp.

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