TLE2 antibody

Principal name

TLE2 antibody

Alternative names for TLE2 antibody

Transducin-like enhancer protein 2, TLE2, GRG2

SwissProt ID

Q04725 (Human), Q9WVB2 (Mouse)

Gene ID

7089 (TLE2)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit, Mouse

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Flow Cytometry (F)

Background of TLE2 antibody

The Notch signaling pathway controls cellular interactions important for the specification of a variety of fates in both invertebrates and vertebrates. Key players in the Notch pathway are the TLE genes (for transducin-like enhancer of split, also designated ESG for enhancer of split groucho), which are human homologs of the Drosophila groucho gene. Groucho is a transcriptional repressor that plays a key role in neurogenesis, segmentation and sex determination. TLEs associate with chromatin in live cells and specifically with Histone H3, but not with other core histones. Expression of the TLE genes, TLE1, TLE2, TLE3 and TLE4, correlate with immature epithelial cells that are progressing toward a terminally differentiated state, suggesting a role during epithelial differentiation. TLE1, TLE2 and TLE3 have elevated expression in cervial squamous metaplasias and carcinomas, while TLE4 is most highly expressed in the brain, particularly in the caudate nucleus. TLE1 and TLE4 contain SP and WD40 domains, through which TLE1 binds AML1 to inhibit AML1-induced transactivation of the CSF1 receptor. In early stages of cell differentiation, TLE1 is up-regulated, and TLE2 and TLE4 are down-regulated. In later stages, TLE2 and TLE4 are up-regulated, and expression of TLE1 decreases. TLE1 and TLE2 genes map in a tandem array at chromosomal location 19p13.3. The genetic loci for TLE3 and TLE4 are chromosomes 15q22 and 9, respectively.

General readings

Higa,L.A., (2006) Nat. Cell Biol. 8 (11), 1277-1283

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

TLE2 antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human liver tissue using anti-TLE2 mouse monoclonal antibody. (TA504240) Mouse IgG1 OTI5A6 Purified Hu F, ICC/IF, P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

TLE2 antibody

Western blot analysis of extracts from LOVO cells, using TLE2 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TLE2 antibody

WB Suggested Anti-TLE2 Antibody Titration: 0.2-1 ug/ml; Positive Control: Transfected 293T Rabbit IgG Purified Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

TLE2 antibody

Western blot (WB) analysis of TLE2 antibody (Cat.-No.: AP06713PU-N) in extracts from hela cells. Rabbit Aff - Purified Hu E, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

TLE2 (C-term) antibody

TLE2 Antibody (C-term) (AP54267PU-N) western blot analysis in mouse lung tissue lysates (35 µg/lane). This demonstrates the TLE2 antibody detected the TLE2 protein (arrow). Rabbit Ig Aff - Purified Hu, Ms WB
0.4 ml / €370.00
  Acris Antibodies GmbH

TLE2 antibody

Western Blot analysis of TLE2 expression in transfected 293T cell line (H00007089-T01) by TLE2 MaxPab polyclonal antibody.

Lane 1: TLE2 transfected lysate(81.73 KDa).
Lane 2: Non-transfected lysate. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

TLE2 antibody

Western blot analysis of extracts from LOVO cells, using TLE2 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, WB
50 µg / €205.00
  Assay Biotech

TLE2 antibody

Western blot analysis of extracts from LOVO cells, using TLE2 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, WB
0.1 mg / €310.00
  Assay Biotech

TLE2 antibody

Transfected 293T; WB Suggested Anti-TLE2 Antibody Titration: 0.2-1 ug/ml. Positive Control: Transfected 293T; TLE2 antibody - N-terminal region (ARP32347_P050) in Transfected 293T cells using Western Blot Rabbit Aff - Purified Hu, Ms, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

TLE2 antibody

Immunohistochemical analysis of TLE2 staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Hu P, WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

TLE2 antibody

Immunohistochemical analysis of TLE2 staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Hu P, WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

TLE2 antibody

Immunohistochemical analysis of TLE2 staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Hu P, WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

TLE2 antibody

Western Blot:   TLE2 Antibody [NBP1-32158]- (30 µg of whole cell lysate) A:H1299 7.5% SDS PAGE diluted at 1:1500 Rabbit IgG Hu ICC/IF, WB
0.1 ml / €420.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

TLE2 (transcript variant 1)

TLE2 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

TLE2

TLE2 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

TLE2

TLE2 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

TLE2 293T Cell Transient Overexpression Lysate(Denatured)

TLE2 293T Cell Transient Overexpression Lysate(Denatured)  
0.1 ml / €270.00
  Abnova Taiwan Corp.

TLE2 overexpression lysate

TLE2 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

TLE2 overexpression lysate

TLE2 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

19 Item(s)

per page
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