TLE2 antibody

Principal name

TLE2 antibody

Alternative names for TLE2 antibody

Transducin-like enhancer protein 2, TLE2, GRG2

SwissProt ID

Q04725 (Human), Q9WVB2 (Mouse)

Gene ID

7089 (TLE2), 21886 (Tle2)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit, Mouse

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Paraffin Sections (P), Flow Cytometry (F), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of TLE2 antibody

The Notch signaling pathway controls cellular interactions important for the specification of a variety of fates in both invertebrates and vertebrates. Key players in the Notch pathway are the TLE genes (for transducin-like enhancer of split, also designated ESG for enhancer of split groucho), which are human homologs of the Drosophila groucho gene. Groucho is a transcriptional repressor that plays a key role in neurogenesis, segmentation and sex determination. TLEs associate with chromatin in live cells and specifically with Histone H3, but not with other core histones. Expression of the TLE genes, TLE1, TLE2, TLE3 and TLE4, correlate with immature epithelial cells that are progressing toward a terminally differentiated state, suggesting a role during epithelial differentiation. TLE1, TLE2 and TLE3 have elevated expression in cervial squamous metaplasias and carcinomas, while TLE4 is most highly expressed in the brain, particularly in the caudate nucleus. TLE1 and TLE4 contain SP and WD40 domains, through which TLE1 binds AML1 to inhibit AML1-induced transactivation of the CSF1 receptor.

General readings

Higa,L.A., (2006) Nat. Cell Biol. 8 (11), 1277-1283

  1. Quick-Filters:
  2. Highly Validated (1)

20 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

TLE2 antibody

  TLE2 mouse monoclonal antibody, clone OTI5A6 (formerly 5A6)  
Immunohistochemical staining of paraffin-embedded Carcinoma of Human liver tissue using anti-TLE2 mouse monoclonal antibody. (TA504240) Mouse IgG1 OTI5A6 Purified Hu F, ICC/IF, P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

TLE2 antibody

  Rabbit polyclonal anti-TLE2 antibody  
Western blot analysis of extracts from LOVO cells, using TLE2 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TLE2 antibody

  Rabbit Polyclonal Anti-TLE2 Antibody  
WB Suggested Anti-TLE2 Antibody Titration: 0.2-1 ug/ml; Positive Control: Transfected 293T Rabbit IgG Purified Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

TLE2 antibody

Western blot (WB) analysis of TLE2 antibody (Cat.-No.: AP06713PU-N) in extracts from hela cells. Rabbit Aff - Purified Hu E, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

TLE2 (C-term) antibody

TLE2 Antibody (C-term) (AP54267PU-N) western blot analysis in mouse lung tissue lysates (35 µg/lane). This demonstrates the TLE2 antibody detected the TLE2 protein (arrow). Rabbit Ig Aff - Purified Hu, Ms WB
0.4 ml / €370.00
  Acris Antibodies GmbH

TLE2 antibody

Western blot analysis of extracts from LOVO cells, using TLE2 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, WB
50 µg / €230.00
  Assay Biotech

TLE2 antibody

Western blot analysis of extracts from LOVO cells, using TLE2 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, WB
0.1 mg / €330.00
  Assay Biotech

CRISPR

Catalog No. Species Donor Vector  

Tle2 - mouse gene knockout kit via CRISPR

Tle2 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Tle2 - mouse gene knockout kit via CRISPR

Tle2 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Tle2 - mouse gene knockout kit via CRISPR

Tle2 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Tle2 - mouse gene knockout kit via CRISPR

Tle2 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

TLE2 (transcript variant 1)

  Recombinant protein of human transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila) (TLE2), transcript variant 1  
TLE2 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

Lysates

Catalog No.    

TLE2 overexpression lysate

TLE2 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

TLE2 overexpression lysate

TLE2 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, TLE2 (mGFP-tagged) - Human transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila) (TLE2), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, TLE2 (mGFP-tagged) - Human transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila) (TLE2), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, TLE2 (mGFP-tagged)-Human transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila) (TLE2), transcript variant 3, 200 uL, >10^7 TU/mL

Lenti ORF particles, TLE2 (mGFP-tagged)-Human transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila) (TLE2), transcript variant 3, 200 uL, >10^7 TU/mL  
200 µl / €1,270.00
  OriGene Technologies, Inc.

Lenti ORF particles, TLE2 (Myc-DDK tagged) - Human transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila) (TLE2), transcript variant 1 , 200 uL, >10^7 TU/mL

Lenti ORF particles, TLE2 (Myc-DDK tagged) - Human transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila) (TLE2), transcript variant 1 , 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

Lenti ORF particles, TLE2 (Myc-DDK-tagged)-Human transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila) (TLE2), transcript variant 3, 200 uL, >10^7 TU/mL

Lenti ORF particles, TLE2 (Myc-DDK-tagged)-Human transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila) (TLE2), transcript variant 3, 200 uL, >10^7 TU/mL  
200 µl / €1,140.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Tle2 (GFP-tagged) - Mouse transducin-like enhancer of split 2, homolog of Drosophila E(spl) (Tle2), 200 uL, >10^7 TU/mL

Lenti ORF particles, Tle2 (GFP-tagged) - Mouse transducin-like enhancer of split 2, homolog of Drosophila E(spl) (Tle2), 200 uL, >10^7 TU/mL  
200 µl / €1,470.00
  OriGene Technologies, Inc.

Lenti ORF particles, Tle2 (Myc-DDK-tagged) - Mouse transducin-like enhancer of split 2, homolog of Drosophila E(spl) (Tle2), 200 uL, >10^7 TU/mL

Lenti ORF particles, Tle2 (Myc-DDK-tagged) - Mouse transducin-like enhancer of split 2, homolog of Drosophila E(spl) (Tle2), 200 uL, >10^7 TU/mL  
200 µl / €1,320.00
  OriGene Technologies, Inc.

20 Item(s)

per page
  • LinkedIn