TLE4 antibody

Principal name

TLE4 antibody

Alternative names for TLE4 antibody

Transducin-like enhancer protein 4, KIAA1261, GRG4, Groucho-related protein 4

SwissProt ID

O42478 (Xenla), Q04727 (Human), Q07141 (Rat), Q62441 (Mouse)

Gene ID

7091 (TLE4), 21888 (Tle4), 25565

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Chk (Chicken), African clawed frog

Available hosts

Mouse, Rabbit

Available applications

ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E)

Background of TLE4 antibody

The Notch signaling pathway controls cellular interactions important for the specification of a variety of fates in both invertebrates and vertebrates. Key players in the Notch pathway are the TLE genes (for transducin-like enhancer of split, also designated ESG for enhancer of split groucho), which are human homologs of the Drosophila groucho gene. Groucho is a transcriptional repressor that plays a key role in neurogenesis, segmentation and sex determination. TLEs associate with chromatin in live cells and specifically with Histone H3, but not with other core histones. Expression of the TLE genes, TLE1, TLE2, TLE3 and TLE4, correlate with immature epithelial cells that are progressing toward a terminally differentiated state, suggesting a role during epithelial differentiation. TLE1, TLE2 and TLE3 have elevated expression in cervial squamous metaplasias and carcinomas, while TLE4 is most highly expressed in the brain, particularly in the caudate nucleus. TLE1 and TLE4 contain SP and WD40 domains, through which TLE1 binds AML1 to inhibit AML1-induced transactivation of the CSF1 receptor. In early stages of cell differentiation, TLE1 is up-regulated, and TLE2 and TLE4 are down-regulated.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

TLE4 antibody

  Rabbit polyclonal anti-TLE4 antibody  
Western blot analysis of extracts from Jurkat cells, 293 cells and HuvEc cells, using TLE4 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TLE4 antibody

  Rabbit Polyclonal Anti-TLE4 Antibody  
WB Suggested Anti-TLE4 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:62500; Positive Control: THP-1 cell lysate Rabbit IgG Purified Hu P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

TLE4 antibody

Western blot (WB) analysis of TLE4 antibody (Cat.-No.: AP06714PU-N) in extracts from Jurkat cells. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

TLE4 (N-term) antibody

TLE4 Antibody (N-term) (AP54268PU-N) western blot analysis in MCF-7 cell line lysates (35 µg/lane). This demonstrates the TLE4 antibody detected the TLE4 protein (arrow). Rabbit Ig Aff - Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

TLE4 antibody

Western blot analysis of extracts from Jurkat/293/HuvEc cells, using TLE4 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
50 µg / €230.00
  Assay Biotech

TLE4 antibody

Western blot analysis of extracts from Jurkat/293/HuvEc cells, using TLE4 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €330.00
  Assay Biotech

CRISPR

Catalog No. Species Donor Vector  

Tle4 - mouse gene knockout kit via CRISPR

Tle4 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Tle4 - mouse gene knockout kit via CRISPR

Tle4 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Tle4 - mouse gene knockout kit via CRISPR

Tle4 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Tle4 - mouse gene knockout kit via CRISPR

Tle4 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

TLE4 overexpression lysate

TLE4 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Tle4 (Myc-DDK-tagged) - Mouse transducin-like enhancer of split 4, homolog of Drosophila E(spl) (Tle4), 200 uL, >10^7 TU/mL

Lenti ORF particles, Tle4 (Myc-DDK-tagged) - Mouse transducin-like enhancer of split 4, homolog of Drosophila E(spl) (Tle4), 200 uL, >10^7 TU/mL  
200 µl / €1,330.00
  OriGene Technologies, Inc.

Rat Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Tle4 (GFP-tagged ORF) - Rat transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) (Tle4), 200 uL, >10^7 TU/mL

Lenti ORF particles, Tle4 (GFP-tagged ORF) - Rat transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) (Tle4), 200 uL, >10^7 TU/mL  
200 µl / €1,440.00
  OriGene Technologies, Inc.

Lenti ORF particles, Tle4 (Myc-DDK-tagged ORF) - Rat transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) (Tle4), 200 uL, >10^7 TU/mL

Lenti ORF particles, Tle4 (Myc-DDK-tagged ORF) - Rat transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) (Tle4), 200 uL, >10^7 TU/mL  
200 µl / €1,290.00
  OriGene Technologies, Inc.

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