TLR7 antibody

Principal name

TLR7 antibody

Alternative names for TLR7 antibody

Toll-like receptor 7

SwissProt ID

P58681 (Mouse), Q9NYK1 (Human)

Gene ID

51284 (TLR7), 170743 (Tlr7)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Fe (Feline), Por (Porcine), Bov (Bovine), Can (Canine), Eq (Equine), Mky (Monkey), Prim (Primate)

Available hosts

Rabbit, Mouse, Goat

Available applications

Enzyme Immunoassay (E), Paraffin Sections (P), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Dot blot (Dot), Frozen Sections (C), Flow Cytometry (F)

Background of TLR7 antibody

The mammalian host defense system is essentially regulated by highly conserved Toll-like receptor (TLR) family of proteins. At least 13 TLRs have been identified and cloned in mammalian cells which recognize molecular products/signals from all the major classes of pathogens and activation of innate immunity. The Toll signaling to NF-Kb starts form conserved Toll-IL-1-resistance (TIR) domain, which mediated the coupling of TIR adaptor molecules (MyD88, Mal, TICAM and TRAM) and caused production of inflammatory cytokines such as IL-1, IL-6, IL-8 , TNFa, and IL-12, chemokines and co-stimulatory molecules such as CD40, CD80 and CD86. In the presence of inflammatory cytokines and binding of adaptor molecule, MyD88 that binds FADD and triggers apoptosis through the caspase cascade. TLR induced apoptosis pathway appears to be a repertoire of defense mechanism utilized by innate defense mechanism. The constitutive expression of many human TLRs (1, 2, 3) have been shown on the surface of myeloid lineage cells by RT-PCR and use of specific monoclonal antibodies. Upon activation of these receptors by their respective chemokines and ligands have been shown in literature on various cell lines including endothelial, epithelial and other cells. The expression of TLR 3, 7, 8 and 9 are mainly found on endosomal lysosomal compartments. Human TLR3 is expressed in human fibroblasts cells and TLR 9 in in-vitro derived DC cells. There is significant evidence of TLR involvement is many systemic disorders following bacterial infection including sepsis, peridontitis, cardiac ischemia, cerebral palsy and others, understanding the TLRs involvement in these conditions will allow therapeutic interventions at the receptor level for treatment of these disorders.
The TLR are highly conserved protein and share structural and functional domains across species. These receptors recognize pathogen associated molecular patters (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines needed for production of immediate immunity. The cell-surface TLRs, including TLR1, TLR2, TLR4, and TLR6, recognize microbial membrane lipids, whereas TLR3, TLR7, TLR8, and TLR9 recognize pathogen-derived nucleotides in intracellular compartments. TLR7 and TLR9 respond to host-derived nucleotides as well, and they have been implicated in a variety of autoimmune diseases. TLR2 and TLR5 mRNA was detected in the CD8(+) T cells from cord blood. The expression of TLR4 and TLR5 are reduced in asthmatic patients which may be partly responsible for immunopathological mechanism of asthma by reducing the release of Th1 anti-inflammatory cytokines (4). TLR7 is a membrane bound protein with two TMD. The first human toll like receptor to be identified, TLR4, senses lipopolysaccharide (LPS) while TLR2 on the other hand senses diacylated or triacylated lipopeptides after heterodimerizing with either TLR6 or TLR1, respectively. The conserved cytoplasmic TIR (Toll/IL-1 receptor) domains of the IL-1 and Toll-like receptors are the critical focal point for the generation of ligand-induced cytoplasmic signaling cascades. For signaling all the TLRs utilize one or more of the four known TIR-containing adaptor molecules: MyD88, TIRAP/MAL, TRIF, and TRAM. Human TLR2 is a 839 amino acid (105 kDa) type I trans-membrane receptor protein characterized by extracellular domains with leucine-rich repeats and a cytoplasmic domain with type I IL-1 receptor. The TLR 2 and 4 are pattern recognition receptors and signaling molecules in response to bacterial lipoproteins and is involved in innate immunity. TLR4 is expressed on peripheral blood and together with MD-2 and CD14 is responsible for LPS signaling recognition. Many specific adapter molecules (TICAM, MyD88, ICAM2, TRAM, TIRAP, TRIF) are involved in signaling of several other TLRs.

General readings

Lee J., et al. (2003) Proc. Natl. Acad. Sci. USA. 100, 6646-6651
Crozat K., et al. (2004) Proc. Natl. Acad. Sci. USA. 101, 6835-3836
Muzio M., et al. (1998) J. Exp. Med. 187, 2097-2101
Lund JM., et al. (2002) Nature 420, 329-333

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

TLR7 (465-483) antibody

Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit IgG Hu, Ms P, WB
50 µl / €470.00
  Acris Antibodies GmbH

TLR7 (900-950) antibody

Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit IgG Purified Hu F, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

TLR7 antibody

IHC staining of human FFPE tonsil section (Vermi William courtesy) Mouse IgG1 66H3 Purified Can, Hu C, F, P
50 µg / €330.00
  Dendritics SAS

TLR7 antibody

IHC staining of human FFPE tonsil section (Vermi William courtesy) Mouse IgG1 66H3 Purified Can, Hu C, F, P
0.1 mg / €440.00
  Dendritics SAS

TLR7 (Center) antibody

Western blot analysis of TLR7 in Daudi cell lysates with TLR7 antibody at (A) 0.5, (B) 1, and (C) 2 ug/mL. Rabbit IgG Purified Hu, Ms E, ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

TLR7 antibody

Predicted cell location: Cytoplasm. Positive control: Human tonsil tissue. Recommended dilution: 1/10-50 The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using TLR7 antibody at dilution 1/10. (Original magnification: ×100) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

TLR7 antibody

Predicted cell location: Cytoplasm, Cell membrane. Positive control: Human tonsil tissue. Recommended dilution: 1/10-50 The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using TLR7 antibody at dilution 1/10. (Original magnification: ×200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

TLR7 antibody

Flow Cytometry: TLR7 Antibody [TA336419] - Intracellular flow analysis of TLR7 in 10^6 ThP1 cells using 2 ug of TA336419.  Shaded histogram represents cells without antibody; green represents isotype control; red represents TLR7 antibody.  Intracellular f Rabbit Purified Hu, Ms C, F
0.1 mg / €325.00
  OriGene Technologies, Inc.

TLR7 antibody

Western Blot: TLR7 Antibody [TA336447] - Western blot analysis of TLR7 in Ramos cell lysate using TA336447 at 1:500. Rabbit Purified Hu, Ms P, WB
0.2 ml / €325.00
  OriGene Technologies, Inc.

TLR7 antibody

Western Blot: TLR7 Antibody [TA336727] - Western Blot on Ramos whole cell extract. Rabbit Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TLR7 antibody

Western Blot: TLR7 Antibody [TA337065] - analysis of human TLR7 in Ramos cell lysate in the 1) absence and 2) presence of immunizing peptide using this antibody. Rabbit IgG Purified Hu, Prim F, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

TLR7 antibody

Western Blot: TLR7 Antibody [TA337080] - analysis of TLR7 in RAW cell lysate using this antibody. Rabbit IgG Purified Hu, Ms, Rt C, F, ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

TLR7 antibody

Western Blot: TLR7 Antibody (4G6) [TA337157] - Analysis of human TLR7 antibody in Ramos and transfected 293T lysate using TLR7 monoclonal antibody at 10 ug/ml. Mouse 4G6 Purified Hu, Ms F, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

TLR7 antibody

Western blot analysis of TLR7 in Daudi cell lysates with TLR7 antibody at (A) 0.5, (B) 1, and (C) 2 μg/ml. Rabbit IgG Purified Hu, Ms ICC/IF, WB
0.1 mg / €370.00
  Acris Antibodies GmbH

TLR7 antibody

Brain, cerebellum: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit Purified Hu, Ms ICC/IF, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

TLR7 (706-728) antibody

Formalin-Fixed Paraffin-Embedded Human Small intestine stained with TLR7 Antibody Cat.-No AP08542PU-N at 5 µg/ml after heat-induced antigen retrieval. Rabbit IgG Aff - Purified Hu, Ms C, F, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

TLR7 Control Peptide

TLR7
0.1 mg / €250.00
  Acris Antibodies GmbH

TLR7 (714-736) antibody

TLR7 Rabbit IgG Aff - Purified Fe, Hu, Ms, Por Dot, E, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

TLR7 (N-term) antibody

Figure 2. Formalin-fixed and paraffin-embedded human hepatocarcinoma reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Ig Purified Hu, Ms P, WB

Regular Price: 0.4 ml / €370.00

Special Price: 0.4 ml / €231.00

  Acris Antibodies GmbH

TLR7 Control Peptide

TLR7
50 µg / €160.00
  Acris Antibodies GmbH

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