TMC6 / EVER1 antibody

Principal name

TMC6 / EVER1 antibody

Alternative names for TMC6 / EVER1 antibody

EVIN1, LAK-4, Transmembrane channel-like protein 6, Epidermodysplasia verruciformis protein 1

SwissProt ID

Q7Z403 (Human)

Gene ID

11322 (TMC6)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit

Available applications

Paraffin Sections (P), Western blot / Immunoblot (WB), Enzyme Immunoassay (E)

Background of TMC6 / EVER1 antibody

EVER gene belongs to larger family of proteins referred to as the transmembrane channel-like protein (TMC) family. EVER1/TMC6 protein, integral membrane protein, is located in the endoplasmic reticulum (ER) of keratinocytes, where it forms a complex with zinc transporter-1 (ZnT-1) a membrane protein responsible for zinc efflux and resistance to zinc toxicity, thereby controlling the cellular zinc balance. The EVER1 protein is predicted to have 10 transmembrane domains and 2 leucine zipper motifs. The EVER1 gene encodes 2 altertively spliced proteins, one of 805 amino acids and the other of 454 amino acids, in the same open reading frame. The EVER genes are thought to be transcribed in numerous tissues including the skin. Mutations in the TMC6 are implicated in the development of the rare autosomal recessive disease Epidermodysplasia Verruciformis (EV). EV is characterized by extreme susceptibility to infection by cutaneous human papillomaviruses (HPV) of the beta genus. The TMC6 genes may be involved in controlling HPV gene expression and replication in epidermal keratinocytes or they may directly affect inte and adaptive immune responses which control the clearance of HPV-infected keratinocytes in EV cases. A recent report indicated an association between genetic variation in the TMC6 region and development of cervical cancer (CxCa) .

12 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

TMC6 / EVER1 (N-term) antibody

  Rabbit Polyclonal EVER1 Antibody  
Western blot analysis of EVER1 in A-20 cell lysate with EVER1 antibody at (A) 1 and (B) 2 ug/ml. Rabbit IgG Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

TMC6 / EVER1 (Center) antibody

  Rabbit Polyclonal EVER1 Antibody  
Western blot analysis of EVER1 in human spleen tissue lysate with EVER1 antibody at (A) 1 and (B) 2 ug/ml. Rabbit IgG Aff - Purified Hu, Ms E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

TMC6 / EVER1 antibody

  Rabbit Polyclonal Anti-TMC6 (EVER1)  
Western blot analysis of rat prostate (lanes 1and 4), rat testis (lanes 2 and 5) and rat placenta (lanes 3 and 6): 1-3. Anti-TMC6 (EVER1) antibody, (1:800). 4-6. Anti-TMC6 (EVER1) antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

TMC6 / EVER1 (N-term) antibody

Human Testis (formalin-fixed, paraffin-embedded) stained with TMC6 antibody AP22604PU-N at 5 µg/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Rabbit Purified Hu, Ms, Rt E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

TMC6 - human gene knockout kit via CRISPR

TMC6 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

TMC6 - human gene knockout kit via CRISPR

TMC6 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

TMC6 - human gene knockout kit via CRISPR

TMC6 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

TMC6 - human gene knockout kit via CRISPR

TMC6 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, TMC6 (mGFP-tagged) - Human transmembrane channel-like 6 (TMC6), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, TMC6 (mGFP-tagged) - Human transmembrane channel-like 6 (TMC6), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, TMC6 (mGFP-tagged) - Human transmembrane channel-like 6 (TMC6), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, TMC6 (mGFP-tagged) - Human transmembrane channel-like 6 (TMC6), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, TMC6 (Myc-DDK tagged) - Human transmembrane channel-like 6 (TMC6), transcript variant 1 , 200 uL, >10^7 TU/mL

Lenti ORF particles, TMC6 (Myc-DDK tagged) - Human transmembrane channel-like 6 (TMC6), transcript variant 1 , 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

Lenti ORF particles, TMC6 (Myc-DDK tagged) - Human transmembrane channel-like 6 (TMC6), transcript variant 2 , 200 uL, >10^7 TU/mL

Lenti ORF particles, TMC6 (Myc-DDK tagged) - Human transmembrane channel-like 6 (TMC6), transcript variant 2 , 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

12 Item(s)

per page
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