TMEM173 / STING antibody

Principal name

TMEM173 / STING antibody

Alternative names for TMEM173 / STING antibody

Transmembrane protein 173, MITA, Stimulator of interferon genes protein, Mediator of IRF3 activation

SwissProt ID

Q2KI99 (Bovin), Q3TBT3 (Mouse), Q86WV6 (Human)

Gene ID

340061 (TMEM173)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Prim (Primate)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Flow Cytometry (F), Immunoprecipitation (IP), Paraffin Sections (P), Luminex (LMNX)

Background of TMEM173 / STING antibody

MPYS (TMEM173 / STING) is a recently identified plasma membrane tetraspanner that is associated with major histocompatibility complex class II (MHC-II) and mediates its transduction of apoptotic signals. It has also been found to be associated with VISA, a mitochondrial protein that acts as an adaptor in virus-triggered signaling. MPYS also interacts with IRF3 and recruits the kinase TBK1 to the VISA-associated complex, acting as a critical mediator of virus-triggered IRF3 activation and interferon (IFN) expression. It is thought that the binding of nucleic acid to the innate immune protein RIG-I causes complex formation between RIG-I, VISA, and MPYS. This complex then recruits TBK1 to phosphorylate IRF3 which then directly activates IFN transcription. At least three isoforms of MPYS are known to exist.

General readings

Gerhard,D.S., Genome Res. 14 (10B), 2121-2127 (2004)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

TMEM173 / STING antibody

Immunohistochemical staining of paraffin-embedded Human breast tissue within the normal limits using anti-TMEM173 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA505032) Mouse IgG2a OTI4E12 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

TMEM173 / STING antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-TMEM173 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA505017) Mouse IgG2b OTI1A7 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

TMEM173 / STING antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-TMEM173 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA505023) Mouse IgG2a OTI4H1 Purified Hu P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

TMEM173 / STING antibody

Immunohistochemical staining of paraffin-embedded Human Kidney tissue within the normal limits using anti-TMEM173 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA505024) Mouse IgG2a OTI4H8 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

TMEM173 / STING antibody

TMEM173 ELISA with 4E12 Capture (TA600184) and 2C9 Detection (TA700186) Antibodies. Substrate used: Recombinant Human TMEM173 (TP308418) Mouse IgG1 OTI4E12 Purified Hu E, LMNX
0.1 mg / €325.00
  OriGene Technologies, Inc.

TMEM173 / STING antibody

TMEM173 ELISA with 4A7 Capture (TA600185) and 4E12 Detection (TA700187) Antibodies. Substrate used: Recombinant Human TMEM173 (TP308418) Mouse IgG1 OTI4A7 Purified Hu E, LMNX
0.1 mg / €325.00
  OriGene Technologies, Inc.

TMEM173 / STING antibody

TMEM173 ELISA with 1G5 Capture (TA600186) and 4H8 Detection (TA700184) Antibodies. Substrate used: Recombinant Human TMEM173 (TP308418) Mouse IgG1 OTI1G5 Purified Hu E, LMNX
0.1 mg / €325.00
  OriGene Technologies, Inc.

TMEM173 / STING antibody

TMEM173 ELISA with 1A7 Capture (TA600187) and 4H8 Detection (TA700184) Antibodies. Substrate used: Recombinant Human TMEM173 (TP308418) Mouse IgG1 OTI1A7 Purified Hu E, LMNX
0.1 mg / €325.00
  OriGene Technologies, Inc.

TMEM173 / STING antibody

TMEM173 ELISA with 2C9 Capture (TA600188) and 4E12 Detection (TA700187) Antibodies. Substrate used: Recombinant Human TMEM173 (TP308418) Mouse IgG1 OTI2C9 Purified Hu E, LMNX
0.1 mg / €325.00
  OriGene Technologies, Inc.

TMEM173 / STING antibody

TMEM173 ELISA with 4E12 Capture (TA600184) and 4H8 Detection (TA700184) Antibodies. Substrate used: Recombinant Human TMEM173 (TP308418) Mouse IgG1 OTI4H8 Purified Hu E, LMNX
50 µg / €345.00
  OriGene Technologies, Inc.

TMEM173 / STING antibody

TMEM173 ELISA with 2C9 Capture (TA600188) and 1A7 Detection (TA700185) Antibodies. Substrate used: Recombinant Human TMEM173 (TP308418) Mouse IgG1 OTI1A7 Purified Hu E, LMNX
50 µg / €345.00
  OriGene Technologies, Inc.

TMEM173 / STING antibody

TMEM173 ELISA with 4A7 Capture (TA600185) and 4E12 Detection (TA700187) Antibodies. Substrate used: Recombinant Human TMEM173 (TP308418) Mouse IgG1 OTI4E12 Purified Hu E, LMNX
50 µg / €345.00
  OriGene Technologies, Inc.

TMEM173 / STING antibody

Western blot analysis of MPYS in A-20 cell lysate with MPYS antibody at (A) 1 and (B) 2 ug/mL. Rabbit IgG Aff - Purified Hu, Ms E, ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

TMEM173 / STING antibody

Western Blot: TMEM173/MPYS Antibody [TA337001] - Analysis of STING in Rh30 lysate using STING antibody at 7 ug/ml. Goat anti-rabbit Ig HRP secondary antibody and PicoTect ECL substrate solution were used for this test. Rabbit Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

TMEM173 / STING antibody

Immunohistochemistry-Paraffin: TMEM173/MPYS Antibody [TA337033] - Analysis of STING in formalin-fixed, paraffin-embedded human breast tumor using an isotype control (top left) and this antibody (bottom left, right) at 5 ug/ml. Rabbit Purified Hu, Ms, Prim, Rt ICC/IF, P
0.1 mg / €325.00
  OriGene Technologies, Inc.

TMEM173 / STING antibody

Western blot analysis of extracts (10ug) from 1 cell line by using anti-TMEM173 monoclonal antibody at 1:200. Mouse IgG1 OTI2C9 Purified Hu F, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

TMEM173 / STING antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TMEM173 (RC208418, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-TMEM173. Mouse IgG1 OTI1A3 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

TMEM173 / STING antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TMEM173 (RC208418, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-TMEM173. Mouse IgG1 OTI1G5 Purified Hu F, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

TMEM173 / STING antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TMEM173 (RC208418, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-TMEM173. Mouse IgG1 OTI2C8 Purified Hu F, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

TMEM173 / STING antibody

Immunohistochemical staining of paraffin-embedded Human colon tissue within the normal limits using anti-TMEM173 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA505021) Mouse IgG1 OTIB10 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

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