TMPO / LAP2 antibody

Principal name

TMPO / LAP2 antibody

Alternative names for TMPO / LAP2 antibody

Thymopoietin beta/gamma, TPRP beta/gamma, Lamina-associated polypeptide 2 isoforms beta/gamma

SwissProt ID

P42167 (Human), Q61029 (Mouse)

Gene ID

7112 (TMPO)

Available reactivities

Rt (Rat), Bov (Bovine), Hu (Human), Ms (Mouse), Xen (Xenopus), Can (Canine), Chk (Chicken), Ze (Zebrafish), African clawed frog

Available hosts

Hamster, Mouse, Rabbit

Available applications

Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E)

Background of TMPO / LAP2 antibody

Lamins are type V intermediate filament proteins and are grouped into constitutively expressed B-type lamins and developmentally regulated A-type lamins. Lamin-binding proteins in the nuclear lamina and the nuclear interior include several protein families and/or types of proteins in higher eukaryotes such as the inner nuclear membrane proteins, lamin B receptor, emerin, and MANI, three isoforms of lamina-associated polypeptide 1 (LAP1), and several isoforms of LAP2. Up to six LAP 2 isoforms derive from a single gene by alternative splicing in mammals and various isoforms have been described in Xenopus. The best characterized LAP2 isoforms are the inner nuclear membrane protein LAP2 beta and the nucleoplasmic protein LAP2 alpha, which are identical in their N-terminal 187-amino acid constant region but differ in their C termini. While LAP2 beta binds to B-type lamins at the nuclear periphery and was suggested to regulate nuclear lamina growth , LAP2 alpha specifically interacts with A-type lamins within the nuclear interior as part of a detergent/salt-resistant nucleoskeletal structure.

General readings

General / background references:Nili E et al. Nuclear membrane protein LAP2beta mediates transcriptional repression alone and together with its binding partner GCL (germ-cell-less). J Cell Sci 114:3297-307 (2001). PubMed PMID: 11591818
Alsheimer M et al. Architecture of the nuclear periphery of rat pachytene spermatocytes: distribution of nuclear envelope proteins in relation to synaptonemal complex attachment sites. Mol Biol Cell 10:1235-45 (1999). PubMed PMID: 10198069
Goldberg M et al. The nuclear lamina: molecular organization and interaction with chromatin. Crit Rev Eukaryot Gene Expr 9:285-93 (1999). PubMed PMID: 10651245

2 Item(s)

per page

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

TMPO / LAP2 (transcript variant 2)

  Recombinant protein of human thymopoietin (TMPO), transcript variant 2  
TMPO / LAP2 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €748.00
  OriGene Technologies, Inc.

TMPO / LAP2 (transcript variant 2)

  Recombinant protein of human thymopoietin (TMPO), transcript variant 2  
TMPO / LAP2 Human > 95 %
Preparation: .
Purity Detail: >95% as determined by SDS-PAGE and Coomassie blue staining.
E. coli
10 µg / €299.00
  OriGene Technologies, Inc.

2 Item(s)

per page
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