TMPRSS3 antibody

Principal name

TMPRSS3 antibody

Alternative names for TMPRSS3 antibody

Transmembrane protease serine 3, ECHOS1, TADG12, TADG-12, Tumor-associated differentially-expressed gene 12 protein

SwissProt ID

P57727 (Human), Q8K1T0 (Mouse)

Gene ID

64699 (TMPRSS3), 140765 (Tmprss3)

Available reactivities

Hu (Human), Ms (Mouse), Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit), Rt (Rat), Ze (Zebrafish)

Available hosts

Mouse, Goat, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Frozen Sections (C)

Background of TMPRSS3 antibody

Extracellular proteases mediate the digestion of neighboring extracellular matrix components in initial tumor growth, allow desquamation of tumor cells into the surrounding environment, provide the basis for invasion of basement membranes in targeted metastatic organs and are required for release and activation of many growth and angiogenic factors. The TMPRSS3 (also known as ECHOS1) gene, which encodes a transmembrane serine protease, has been found to be responsible for two non-syndromic recessive deafness loci located on human chromosome 21q22.3, DFNB8 and DFNB10.TMPRSS3, a 437 amno acid membrane bound serine protease and a member of the S1 peptidase family. TMPRSS3 contains an amino-terminal signalanchor sequence and a glycosylated extracellular region containing the serine protease domain. Two novel missense mutations of TMPRSS3, W251C and P404L, alter the highly conserved amino acids of the serine protease domain. TMPRSS3 is expressed in many tissues, including fetal cochle,a a subset of pancreatic cancer and various other cancer tissues. TMPRSS3 is also overexpressed in cancer, suggesting that it may be important for processes in metastasis formation and tumor invasion.

General readings

Lee YJ, Park D, Kim SY, Park WJ.
Pathogenic mutations but not polymorphisms in congenital and childhood onset autosomal recessive deafness disrupt the proteolytic activity of TMPRSS3.
J Med Genet. 2003 Aug;40(8):629-31. No abstract available.
PMID: 12920079

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

TMPRSS3 antibody

  Goat Polyclonal Antibody against TMPRSS3  
TA303305 (0.1µg/ml) staining of A431 cell lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Hu, Ms WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

TMPRSS3 antibody

  Rabbit polyclonal anti-TMPRSS3 antibody  
Western blot analysis of extracts from HUVEC cells, using TMPRSS3 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TMPRSS3 (Center) antibody

  Rabbit polyclonal TMPRSS3 Antibody (Center)  
Western blot analysis of TMPRSS3 Antibody (Center) (Cat. #TA324881) in Hela, 293 cell line lysates (35ug/lane). TMPRSS3 (arrow) was detected using the purified Pab. Rabbit Hu WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

TMPRSS3 antibody

  Rabbit Polyclonal Anti-Tmprss3 Antibody  
Host: Rabbit; Target Name: Tmprss3; Sample Tissue: Mouse Kidney lysates; Antibody Dilution: 1.0 ug/ml Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

TMPRSS3 antibody

  Rabbit Polyclonal Anti-TMPRSS3 Antibody - N-terminal region  
WB Suggested Anti-TMPRSS3 Antibody Titration: 5% Milk; Positive Control: Mouse Brain lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

TMPRSS3 antibody

  Rabbit Polyclonal Anti-TMPRSS3 Antibody - N-terminal region  
WB Suggested Anti-TMPRSS3 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:1562500; Positive Control: A549 cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

TMPRSS3 antibody

  Rabbit Polyclonal Anti-TMPRSS3 Antibody  
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using (TMPRSS3 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: ×200) Rabbit IgG Purified Hu, Ms E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

TMPRSS3 antibody

Immunohistochemistry analyzes of TMPRSS3 antibody (Cat.-No AP20427PU-N) in paraffin-embedded human breast carcinoma tissue. Rabbit Aff - Purified Hu, Ms ICC/IF, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

TMPRSS3 antibody

Immunofluorescence of COS cells 293T transfected with pHATMPRSS3. Rabbit Aff - Purified Hu C, E, WB
25 µg / €430.00
  Acris Antibodies GmbH

TMPRSS3 antibody

Immunofluorescence of COS cells transfectecd with pHATMPRSS3 Rabbit Serum Hu C, E, WB
0.2 ml / €400.00
  Acris Antibodies GmbH

TMPRSS3 antibody

Immunofluorescence analysis of HeLa cells, using TMPRSS3 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, ICC/IF, WB
50 µg / €230.00
  Assay Biotech

TMPRSS3 antibody

Immunofluorescence analysis of HeLa cells, using TMPRSS3 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, ICC/IF, WB
0.1 mg / €330.00
  Assay Biotech

CRISPR

Catalog No. Species Donor Vector  

Tmprss3 - mouse gene knockout kit via CRISPR

Tmprss3 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Tmprss3 - mouse gene knockout kit via CRISPR

Tmprss3 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Tmprss3 - mouse gene knockout kit via CRISPR

Tmprss3 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Tmprss3 - mouse gene knockout kit via CRISPR

Tmprss3 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

TMPRSS3 overexpression lysate

TMPRSS3 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

TMPRSS3 overexpression lysate

TMPRSS3 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, TMPRSS3 (mGFP-tagged) - Human transmembrane protease, serine 3 (TMPRSS3), transcript variant A, 200 uL, >10^7 TU/mL

Lenti ORF particles, TMPRSS3 (mGFP-tagged) - Human transmembrane protease, serine 3 (TMPRSS3), transcript variant A, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, TMPRSS3 (mGFP-tagged) - Human transmembrane protease, serine 3 (TMPRSS3), transcript variant B, 200 uL, >10^7 TU/mL

Lenti ORF particles, TMPRSS3 (mGFP-tagged) - Human transmembrane protease, serine 3 (TMPRSS3), transcript variant B, 200 uL, >10^7 TU/mL  
200 µl / €960.00
  OriGene Technologies, Inc.

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