TNFAIP3 antibody

Principal name

TNFAIP3 antibody

Alternative names for TNFAIP3 antibody

OTUD7C, Zinc finger protein A20, Tumor necrosis factor alpha-induced protein 3, OTU domain-containing protein 7C, Putative DNA-binding protein A20

SwissProt ID

P21580 (Human), Q60769 (Mouse)

Gene ID

7128 (TNFAIP3), 21929

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Can (Canine)

Available hosts

Mouse, Rabbit, Goat

Available applications

Immunoprecipitation (IP), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Flow Cytometry (F), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P)

Background of TNFAIP3 antibody

Tumor necrosis factor alfa (TNF alfa) treatment to different cells rapidly and profoundly induced various proteins including zinc finger protein called A20 also known as tumor necrosis factor alfa-inducible protein 3(1). The function of A20 is to restrict and terminate inflammatory responses through modulation of the ubiqutination status of central components in NF-kB, interferon regulatory factor 3, IRF3 and apoptosis signal cascades (2). A20 tightly regulates NF-'B signaling by acting as an Ubiquitin editor, removing K63-linked ubiquitin chains and mediating addition of Ub chains that target substrates for degradation. In response to pro inflammatory cytokines, the deubiquitinase A20 interacts with regulatory molecules TAX1BP1, Itch and RNF to form the A20 editable ubiquitin-editing complex. The kinase IKKa and not IKKb is responsible for phosphorylation of TAX1BP1 at Ser593/Ser624 and the phosphorylation of TAXBP1 is pivotal for interaction of A20, Itch, RNF11 and phosphorylated TAXBP1 and down-regulation of signaling by NFkB. Various polymorphisms with in the A20 locus resulted in multiple inflammatory and auto immune disorders including systemic lupus erythaematosis, rheumatoid arthritis, Crohn's disease and psoriasis. A20 is also implicated in tumor suppression in several subsets of B-cell lymphomas (3). The NFkB inhibitory protein A20 significantly improves the recovery of liver function and mass following extended liver resection by optimizing energy production thru improved fatty acid metabolism and reduced inflammation (4). A20 undergoes specific glucose-triggered post-translational modifications (PTM) including O-GlcNAcylation and ubiquitination, which leads to its loss by proteasomal degradation, hence depriving the organism of a key element of its atheroprotective armamentarium and accelerating development of atherosclerotic lesions (5). A20 is a 790 aa (91kDa) protein and expressed in two isoform variants (A20 isoform a and isoform b).

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

TNFAIP3 (C-term) antibody

Western blot analysis of TNFAIP3 in SK-N-SH cell lysate with TNFAIP3 antibody at 1 ug/ml. Rabbit IgG Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

TNFAIP3 (Center) antibody

Western blot analysis of TNFAIP3 in rat lung tissue lysate with TNFAIP3 antibody at (A) 1 and (B) 2 ug/ml. Rabbit IgG Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

TNFAIP3 antibody

Western blot analysis of extracts from RAW264.7 cells, using TNAP3 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TNFAIP3 antibody

Western blot analysis of extracts of various mouse tissues, using TNFAIP3 antibody Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

TNFAIP3 antibody

Western Blot: TNFAIP3 Antibody (59A426) [TA336834] - analysis of A20 using mAb 59A426. A20 migrated as a stack of bands and LPS treatment (200 ng, ) induced a ~58 kDa putative A20 cleavage band* not seen in the untreated control © THP1 cells. A20 Mouse IgG1 59A426 Purified Hu, Ms, Rt F, ICC/IF, IP, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

TNFAIP3 antibody

Host: Rabbit; Target Name: TNFAIP3; Sample Tissue: ACHN whole cell lysates; Antibody Dilution: 1.0 ug/ml Rabbit IgG Purified Can, Hu, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

TNFAIP3 antibody

Small intestine, Human: Formalin-Fixed, Paraffin-Embedded (FFPE) Goat Aff - Purified Bov, Bt, Hst, Hu, Mky, Ms, Por, Prim, Rb P
50 µg / €470.00
  Acris Antibodies GmbH

TNFAIP3 (C-term) antibody

Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit Hu, Ms, Rt E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

TNFAIP3 antibody

TNFAIP3 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

TNFAIP3 antibody

Detection of TNFAIP3 by Western blot in HT1080 cells, wild type. Or transfected with TNFAIP3 were activated with 0.1 µg/mL of rhs TNF-a for 4 hours. TNFAIP3 monoclonal antibody, clone 8E8.38 ( Cat # MAB3716 ) at 1 : 1,000 dilution. Mouse IgG1 8E8.38 Hu WB
50 µg / €730.00
  Abnova Taiwan Corp.

TNFAIP3 antibody

Immunofluorescence analysis of HepG2 cells, using TNAP3 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, ICC/IF, WB
50 µg / €205.00
  Assay Biotech

TNFAIP3 antibody

Immunofluorescence analysis of HepG2 cells, using TNAP3 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, ICC/IF, WB
0.1 mg / €310.00
  Assay Biotech

TNFAIP3 antibody

Immunohistochemical analysis of A20 staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

TNFAIP3 antibody

Immunohistochemical analysis of A20 staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

TNFAIP3 antibody

Immunohistochemical analysis of A20 staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

TNFAIP3 antibody

Immunohistochemistry: TNFAIP3 Antibody (EPR2663) [NBP1-40686] - Immunohistochemical analysis of paraffin-embedded human testis tissue using anti-TNFAIP3 Rabbit IgG EPR2663 Hu F, ICC/IF, P, WB
0.1 ml / €420.00
  Novus Biologicals Inc.

TNFAIP3 antibody

TNFAIP3 Rabbit IgG Aff - Purified Hu, Ms E, ICC/IF, WB
0.1 mg / €360.00
  Novus Biologicals Inc.

TNFAIP3 antibody

TNFAIP3 Rabbit IgG Aff - Purified Hu, Ms E, ICC/IF, WB
50 µg / €290.00
  Novus Biologicals Inc.

TNFAIP3 antibody

Immunohistochemistry-Paraffin: TNFAIP3 Antibody [NBP1-77024] - Human lung tissue with TNFAIP3 antibody at 5 ug/mL._x000d_ Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €440.00
  Novus Biologicals Inc.

TNFAIP3 antibody

Immunohistochemistry-Paraffin: TNFAIP3 Antibody [NBP1-77351] - Human lung tissue with TNFAIP3 antibody at 5 ug/mL._x000d_ Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €440.00
  Novus Biologicals Inc.

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