TNFRSF14 / HVEM antibody

Principal name

TNFRSF14 / HVEM antibody

Alternative names for TNFRSF14 / HVEM antibody

HVEA, Herpesvirus entry mediator A, TR2, Tumor necrosis factor receptor superfamily member 14, Tumor necrosis factor receptor-like 2

SwissProt ID

Q92956 (Human)

Gene ID

8764 (TNFRSF14)

Available reactivities

Hu (Human), Ms (Mouse)

Available hosts

Mouse, Rabbit, Goat, Rat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), ELISA (detection) (E(detection)), Immunoprecipitation (IP), Flow Cytometry (F), EPair for Elisa (EPair)

Background of TNFRSF14 / HVEM antibody

The 122 antibody recognizes human HVEM also known as herpesvirus entry mediator A, tumor necrosis factor receptor superfamily, member 14, TNFRSF14, and tumor necrosis factor receptor like 2. HVEM, a member of the TNFR superfamily, is a type I transmembrane protein containing 2 TNF receptor domains with a predicted molecular weight of approximately 30 kD. HVEM is widely expressed in blood vessels, brain, heart, kidney, liver, lung, prostate, spleen, thymus and other organs. Resting T cells and naïve and memory B cells express high levels of HVEM as well. In humans, HVEM is not expressed in germinal center B cells. Immature dendritic cells express high levels of HVEM that is downregulated upon maturation. HVEM plays an important role in herpes simplex virus pathogenesis by enhancing entry into cells. Signaling through HVEM activates JNK1, NF-?B and AP-1 to control gene expression in response to infection or cellular stress and activate the immune response. HVEM binds to LIGHT and has also been shown to associate with several other proteins including TRAF1, TRAF2, TRAF3, TRAF5, B and T lymphocyte associated protein (BTLA), and estrogen receptor alpha.

General readings

Cheung TC, Humphreys IR, Potter KG, Norris PS, Shumway HM, Tran BR, Patterson G, Jean-Jacques R, Yoon M, Spear PG, Murphy KM, Lurain NS, Benedict CA, Ware CF. From The Cover: Evolutionarily divergent herpesviruses modulate T cell activation by targeting the herpesvirus entry mediator cosignaling pathway. Proc Natl Acad Sci U S A. 2005 Sep 13;102(37):13218-23.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

TNFRSF14 / HVEM antibody

  Goat Polyclonal Antibody against HVEM / TR2  
TA302511 (0.03µg/ml) staining of human thymus lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

TNFRSF14 / HVEM (C-term) antibody

  Rabbit Polyclonal TNFRSF14 Antibody  
Western blot analysis of TNFRSF14 in Raji cell lysate with TNFRSF14 antibody at 2 ug/mL in (A) the absence and (B) the presence of blocking peptide. Rabbit IgG Aff - Purified Hu E, ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

TNFRSF14 / HVEM (N-term) antibody

  Rabbit Polyclonal TNFRSF14 Antibody  
Western blot analysis of TNFRSF14 in mouse thymus tissue lysate with TNFRSF14 antibody at (A) 1 and (B) 2 ug/ml. Rabbit IgG Aff - Purified Hu, Ms ICC/IF, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

TNFRSF14 / HVEM antibody

  Mouse Anti-Human CD270 (HVEM) Purified (25 ug)  
Staining of normal human peripheral blood cells with 0.125 ug of Mouse IgG1 kappa Isotype Control Purified (open histogram) or 0.125 ug of Anti-Human CD270 (HVEM) Purified (filled histogram) followed by Anti-Mouse IgG Biotin and Streptavidin PE . Cells in the lymphocyte gate were used for analysis. Mouse eBioHVEM-122 Purified Hu F, WB
25 µg / €120.00
  OriGene Technologies, Inc.

TNFRSF14 / HVEM antibody

  Rabbit anti-TNFRSF14 Polyclonal Antibody  
Western blot analysis of extracts of HL-60 cell lines, using TNFRSF14 antibody. Rabbit IgG Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

TNFRSF14 / HVEM antibody

  Mouse Monoclonal anti-HVEM (TR2) Antibody  
Human peripheral blood lymphocytes stained with purified 122, followed by biotinylated anti-mouse IgG and Sav-PE Mouse 122 Purified Hu E, F, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

TNFRSF14 / HVEM antibody

  TNFRSF14 mouse monoclonal antibody, clone OTI1F12 (formerly 1F12)  
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TNFRSF14 (RC201167, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-TNFRSF14.(1:2000) Mouse IgG1 OTI1F12 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

TNFRSF14 / HVEM antibody

  TNFRSF14 mouse monoclonal antibody, clone OTI1A7 (formerly 1A7)  
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TNFRSF14 (RC201167, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-TNFRSF14.(1:2000) Mouse IgG1 OTI1A7 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

TNFRSF14 / HVEM antibody

Western blot analysis of TNFRSF14 in Raji cell lysate with TNFRSF14 antibody at 2 µg/ml in (A) the absence and (B) the presence of blocking peptide. Rabbit IgG Purified Hu WB
0.1 mg / €440.00
  Acris Antibodies GmbH

TNFRSF14 / HVEM (N-term) antibody

Western blot analysis of TNFRSF14 in mouse thymus tissue lysate with TNFRSF14 antibody at (A) 1 and (B) 2 µg/ml. Rabbit IgG Purified Hu, Ms WB
0.1 mg / €440.00
  Acris Antibodies GmbH

TNFRSF14 / HVEM antibody

Brain, cortex: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit Aff - Purified Hu ICC/IF, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

TNFRSF14 / HVEM antibody

Figure 1. Staining TNFRSF14 in Spleen by Immunohistochemistry using Formalin-Fixed Paraffin-Embedded (FFPE) tissue. Rabbit Purified Hu, Ms P, WB
50 µg / €470.00
  Acris Antibodies GmbH

TNFRSF14 / HVEM (Center) antibody

Formalin-fixed and paraffin-embedded human lung carcinoma reacted with TNFRSF14 Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Ig Aff - Purified Hu F, P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

TNFRSF14 - human gene knockout kit via CRISPR

TNFRSF14 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

TNFRSF14 - human gene knockout kit via CRISPR

TNFRSF14 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

TNFRSF14 - human gene knockout kit via CRISPR

TNFRSF14 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

TNFRSF14 - human gene knockout kit via CRISPR

TNFRSF14 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

TNFRSF14 / HVEM

  Recombinant protein of human tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) (TNFRSF14)  
TNFRSF14 / HVEM Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

TNFRSF14 / HVEM

  Purified recombinant protein of Human tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) (TNFRSF14).  
TNFRSF14 / HVEM Human > 95 %
Preparation: .
Purity Detail: >95% as determined by SDS-PAGE and Coomassie blue staining.

Regular Price: 20 µg / €199.00

Special Price: 20 µg / €139.00

  OriGene Technologies, Inc.

TNFRSF14 / HVEM (39-202, His-tag)

TNFRSF14 / HVEM Human Purified > 85 % by SDS - PAGE E. coli
0.5 mg / €730.00
  Acris Antibodies GmbH

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