TNFRSF18 / GITR antibody

Principal name

TNFRSF18 / GITR antibody

Alternative names for TNFRSF18 / GITR antibody

AITR, Tumor necrosis factor receptor superfamily member 18, Glucocorticoid-induced TNFR-related protein, Activation-inducible TNFR family receptor

SwissProt ID

O35714 (Mouse), Q9Y5U5 (Human)

Gene ID

8784 (TNFRSF18), 21936 (Tnfrsf18)

Available reactivities

Ms (Mouse), Hu (Human), Rt (Rat)

Available hosts

Rat, Mouse, Rabbit

Available applications

Flow Cytometry (F), Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Immunoprecipitation (IP), Functional assay (FN), Neutralisation (NEUT), Frozen Sections (C)

Background of TNFRSF18 / GITR antibody

TNFRSF18 or GITR (glucocorticoid-induced TNF receptor family-regulated gene) is a 25 kD TNF receptor superfamily member (also known as AITR and TNFRSF18) originally identified in the mouse by comparing untreated and dexamethasone-treated murine T cell hybridoma cells. Human GITR was subsequently identified by searching an expressed sequence tag database. GITR is expressed on activated lymphocytes and is upregulated by T cell receptor engagement. The cytoplasmic domain of GITR is homologous to CD40, 4-1BB and CD27 and has been shown to interact with TRAF 1-3, but not TRAF 5 or 6. GITR signaling has been shown to regulate T cell proliferation and TCR-mediated apoptosis, and to break immunological self-tolerance. GITR appears to be highly expressed on CD4+CD25+ T regulatory cells and has been shown to induce NF-kB activation through TRAF2/NIK signaling. GITR has been proposed to be involved in the development of regulatory T cells and to regulate the activity of Th1 subsets. GITR binds GITRL, a TNF superfamily ligand expressed on endothelial cells, dendritic cells, macrophages, and B cells.

General readings

Lacal PM., et al. (2013) J. Pharmacol. Exp. Ther. 347:164-172.Xufre C., et al. (2013) Int. Immunol. 25:563-574.Shimizu J., et al. (2002) Nat. Immunol. 3:135-142.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

TNFRSF18 / GITR antibody

Immunohistochemical staining of paraffin-embedded Human pancreas tissue using anti-TNFRSF18 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.0) at 120C for 3 min, UM800095)(1:200) Mouse IgG2b UMAB203 Purified Hu P
0.1 ml / €468.00
  OriGene Technologies, Inc.

UltraMAB

TNFRSF18 / GITR antibody

Immunohistochemical staining of paraffin-embedded Human pancreas tissue using anti-TNFRSF18 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.0) at 120C for 3 min, UM800095)(1:200) Mouse IgG2b UMAB203 Purified Hu P
30 µl / €140.00
  OriGene Technologies, Inc.

UltraMAB

TNFRSF18 / GITR (26-115) antibody

Anti-TNFRSF18 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. Mouse IgG2b 2H4 Purified Hu, Ms E, P, WB
50 µg / €345.00
  OriGene Technologies, Inc.

TNFRSF18 / GITR antibody

WB Suggested Anti-TNFRSF18 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:312500; Positive Control: Hela cell lysate Rabbit IgG Purified Hu P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

TNFRSF18 / GITR antibody

WB Suggested Anti-TNFRSF18 Antibody; Titration: 1 ug/ml; Positive Control: Hela Whole Cell Rabbit IgG Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

TNFRSF18 / GITR antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TNFRSF18 (RC219997, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-TNFRSF18. Mouse IgG1 OTI4H5 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

TNFRSF18 / GITR antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TNFRSF18 (RC219997, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-TNFRSF18. Mouse IgG1 OTI1A3 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

TNFRSF18 / GITR antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TNFRSF18 (RC219997, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-TNFRSF18. Mouse IgG1 OTI3A7 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

TNFRSF18 / GITR antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TNFRSF18 (RC219997, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-TNFRSF18. Mouse IgG2a OTI5G4 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

TNFRSF18 / GITR antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TNFRSF18 (RC219997, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-TNFRSF18. Mouse IgG2a OTI1C4 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

TNFRSF18 / GITR antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TNFRSF18 (RC219997, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-TNFRSF18. Mouse IgG1 OTI4A9 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

TNFRSF18 / GITR antibody

Immunohistochemical staining of paraffin-embedded Human lymphoma tissue using anti-TNFRSF18 mouse monoclonal antibody. (TA806606; heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min) Mouse IgG2b OTI9G8 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

TNFRSF18 / GITR antibody

4% PFA fixed/Paraffin embedded mouse Spleen, Lung and Kidney sections from LPS treated mice was subjected to immunohistochemistry staining (DAB) of GITR. Rat IgG2 7C13 Purified Ms F, P
0.1 mg / €440.00
  Acris Antibodies GmbH

TNFRSF18 / GITR antibody

TNFRSF18 / GITR Rat IgG2b YGITR765 Purified Ms F
0.25 mg / €420.00
  Acris Antibodies GmbH

TNFRSF18 / GITR antibody

TNFRSF18 / GITR Rat IgG2b YGITR765 Purified Ms F
0.1 mg / €320.00
  Acris Antibodies GmbH

TNFRSF18 / GITR antibody

TNFRSF18 / GITR Rat IgG2b YGITR765 Purified Ms F
25 µg / €170.00
  Acris Antibodies GmbH

TNFRSF18 / GITR antibody

TNFRSF18 / GITR Rat IgG2b YGITR765 PE Ms F
100 Tests / €300.00
  Acris Antibodies GmbH

TNFRSF18 / GITR antibody

TNFRSF18 / GITR Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

TNFRSF18 / GITR antibody

Western Blot analysis of TNFRSF18 expression in transfected 293T cell line (H00008784-T01) by TNFRSF18 MaxPab polyclonal antibody.

Lane 1: TNFRSF18 transfected lysate(26.51 KDa).
Lane 2: Non-transfected lysate. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

TNFRSF18 / GITR antibody

Western Blot analysis of TNFRSF18 expression in transfected 293T cell line (H00008784-T01) by TNFRSF18 MaxPab polyclonal antibody.

Lane 1: TNFRSF18 transfected lysate(26.51 KDa).
Lane 2: Non-transfected lysate. Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

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