TNFRSF21 / Death receptor 6 (DR6) antibody

Principal name

TNFRSF21 / Death receptor 6 (DR6) antibody

Alternative names for TNFRSF21 / Death receptor 6 (DR6) antibody

Tumor necrosis factor receptor superfamily member 21

SwissProt ID

O75509 (Human), Q9EPU5 (Mouse)

Gene ID

27242 (TNFRSF21), 94185 (Tnfrsf21)

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Ms (Mouse), Rt (Rat), Eq (Equine), Rb (Rabbit)

Available hosts

Rat, Rabbit, Mouse

Available applications

Flow Cytometry (F), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Frozen Sections (C), Paraffin Sections (P)

Background of TNFRSF21 / Death receptor 6 (DR6) antibody

Apoptosis is induced by certain cytokines including TNF and Fas ligand (CD95L) of the TNF family through their death domain containing receptors, TNF-R1 and Fas (CD95). Several novel death receptors including DR3, TRAIL-R1, and TRAIL-R2 were identified.
A new death domain containing receptor in the TNF-R family was cloned and termed DR6 for death receptor-6. Like TNF-R1, DR6 interacts with death domain containing adapter molecule TRADD. Overexpression of DR6 induces apoptosis and activates NF-?B and JNK [1]. DR6 is widely expressed in human tissues and cell lines. The ligand for DR6 has not been identified yet. T cells from DR6-deficient mice showed preference toward Th2 differentiation in vitro, suggesting that DR6, working through JNK functions to attenuate the Th2 response [2]. Other studies of DR6-targeted mutant mice demonstrated that DR6 functions as a regulatory receptor for mediating CD4(+) T cell activation and maintaining proper immune responses [3].

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

TNFRSF21 / Death receptor 6 (DR6) antibody

  Rabbit Polyclonal DR6 Antibody  
Western blot analysis of DR6 in K562 (1,3) and Raji (2,4) whole cell lysate in the absence (1,2) or presence (3,4) of blocking peptide (Catalog no. 2157P) with DR6 antibody at 1:500 dilution. Rabbit IgG Purified Hu E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

TNFRSF21 / Death receptor 6 (DR6) antibody

  Rabbit polyclonal anti-Tnfrsf21 (DR6) antibody  
Western blot analysis of DR6 expression in lysate from Jurkat cells (Lane 1, 2), 3T3 cells (Lane 3) and rat kidney tissue lysate (Lane 4). Rabbit Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

TNFRSF21 / Death receptor 6 (DR6) antibody

  Anti-TNFRSF21 Rabbit Polyclonal Antibody  
Predicted band size: 72 kDa . Positive control: Human fetal brain tissue lysate. Recommended dilution: 1/500-2000. (Gel: 10%SDS-PAGE Lysate: 30 ug Primary antibody: 1/420 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 30 seconds) Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TNFRSF21 / Death receptor 6 (DR6) antibody

  Rabbit Polyclonal Anti-TNFRSF21 Antibody  
WB Suggested Anti-TNFRSF21 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 312500; Positive Control: 721_B cell lysate.TNFRSF21 is supported by BioGPS gene expression data to be expressed in 721_B Rabbit IgG Purified Bov, Can, Eq, Hu, Ms, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

TNFRSF21 / Death receptor 6 (DR6) antibody

  Rabbit Polyclonal Anti-TNFRSF21 Antibody  
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using (TNFRSF21 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

TNFRSF21 / Death receptor 6 (DR6) (42-335) antibody

Flow Cytometry: HEK 293T cells were mock transfected (thin line) or transfected with an expression plasmid coding for the extracellular domain of Human DR6 (thick line). Rat IgG2a Luke-1 Aff - Purified Hu F
0.1 mg / €510.00
  Acris Antibodies GmbH

TNFRSF21 / Death receptor 6 (DR6) (42-335) antibody

Detection of DR6 transiently transfected into HeLa cells (green) using anti-DR6 antibody (DR-6-04-EC). Cell nuclei visualized by DAPI (blue). Mouse IgG1 DR-6-04-EC FITC Hu F
0.1 mg / €330.00
  Acris Antibodies GmbH

TNFRSF21 / Death receptor 6 (DR6) antibody

Detection of DR6 transiently transfected into HeLa cells (green) using anti-DR6 antibody (DR-6-04-EC). Cell nuclei visualized by DAPI (blue). Mouse IgG1 DR-6-04-EC Purified Hu F, ICC/IF, IP
0.1 mg / €260.00
  Acris Antibodies GmbH

TNFRSF21 / Death receptor 6 (DR6) antibody

TNFRSF21 / Death receptor 6 (DR6) Mouse IgG1 DR-06-04-EC Purified Hu F, IP
0.2 mg / €340.00
  Acris Antibodies GmbH

TNFRSF21 / Death receptor 6 (DR6) antibody

Detection of DR6 transiently transfected into HeLa cells (green) using anti-DR6 antibody (Klon DR-6-04-EC). Cell nuclei visualized by DAPI (blue). Mouse IgG1 DR-6-04-EC PE F
0.1 mg / €390.00
  Acris Antibodies GmbH

TNFRSF21 / Death receptor 6 (DR6) (42-56) antibody

Western blot analysis of DR6 in K562 (1,3) and Raji (2,4) whole cell lysate in the
absence (1,2) or presence (3,4) of blocking peptide with SP1298. Rabbit Aff - Purified Hu WB
0.1 mg / €320.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

TNFRSF21 - human gene knockout kit via CRISPR

TNFRSF21 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

TNFRSF21 - human gene knockout kit via CRISPR

TNFRSF21 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

TNFRSF21 - human gene knockout kit via CRISPR

TNFRSF21 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

TNFRSF21 - human gene knockout kit via CRISPR

TNFRSF21 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Tnfrsf21 - mouse gene knockout kit via CRISPR

Tnfrsf21 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Tnfrsf21 - mouse gene knockout kit via CRISPR

Tnfrsf21 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Tnfrsf21 - mouse gene knockout kit via CRISPR

Tnfrsf21 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Tnfrsf21 - mouse gene knockout kit via CRISPR

Tnfrsf21 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

TNFRSF21 / Death receptor 6 (DR6)

  Purified recombinant protein of Human tumor necrosis factor receptor superfamily, member 21 (TNFRSF21)  
TNFRSF21 / Death receptor 6 (DR6) Human > 95 %
Preparation: .
Purity Detail: >95% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
10 µg / €139.00
  OriGene Technologies, Inc.

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