TOP2A antibody

Principal name

TOP2A antibody

Alternative names for TOP2A antibody

TOP2, Top-2, DNA topoisomerase 2-alpha, DNA topoisomerase II alpha isozyme,

SwissProt ID

O42130 (Chick), O46374 (Pig), P11388 (Human), P41516 (Rat), Q01320 (Mouse)

Gene ID

7153 (TOP2A), 5395 (PMS2)

Available reactivities

Hu (Human), Can (Canine), Ms (Mouse), Por (Porcine), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunoprecipitation (IP), Frozen Sections (C), Flow Cytometry (F)

Background of TOP2A antibody

DNA topoisomerase I and II (Topo I and Topo II) are nuclear enzymes that regulate the topological structure of DNA in eukaryotic cells by transiently breaking and rejoining DNA strands. Eukaryotic topoisomerases are capable of relaxing both positive and negative supercoils, whereas prokaryotic topoisomerases relax only negative supercoils. DNA topoisomerases play a role in DNA replication, recombination, and transcription and have been identified as targets of numerous anticancer drugs. Topo I, a ubiquitously expressed, soluble enzyme, acts by introducing a transient break in one strand of DNA, while Topo II acts by making a transient double-strand break. Topo II is encoded by two different genes to generate two distinct isoforms that are designated Topo IIalpha and Topo IIbeta. The 180 kDa isoform, Topo IIbeta, and the 170 kDa isoform, Topo IIalpha, are largely homologous at their N-terminal three quarters, however, the C-terminal segments are considerably divergent, suggesting that these regions may mediate different cellular functions and account for the observed differential tissue expression patterns of the two isoforms.

General readings

Yoshida,K., et al., (2006) Mol. Cell. Biol. 26 (9), 3414-3431

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

TOP2A antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human bladder tissue using anti-TOP2A mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA802384) Mouse IgG2b OTI2A9 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

TOP2A antibody

Immunohistochemical staining of paraffin-embedded Human lymphoma tissue using anti-TOP2A mouse monoclonal antibody. (UM800042; heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH9.0, 120C for 3min) Mouse IgG1 UMAB145 Purified Hu P
0.1 ml / €468.00
  OriGene Technologies, Inc.

UltraMAB

TOP2A antibody

Immunohistochemical staining of paraffin-embedded Human tonsil using anti-TOP2A mouse monoclonal antibody. (UM800043; heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.0, 120C for 3min) Mouse IgG1 UMAB146 Purified Hu P, WB
0.1 ml / €468.00
  OriGene Technologies, Inc.

UltraMAB

TOP2A antibody

Immunohistochemical staining of paraffin-embedded Human lymphoma tissue using anti-TOP2A mouse monoclonal antibody. (UM800042; heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH9.0, 120C for 3min) Mouse IgG1 UMAB145 Purified Hu P
30 µl / €140.00
  OriGene Technologies, Inc.

UltraMAB

TOP2A antibody

Immunohistochemical staining of paraffin-embedded Human tonsil using anti-TOP2A mouse monoclonal antibody. (UM800043; heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.0, 120C for 3min) Mouse IgG1 UMAB146 Purified Hu P, WB
30 µl / €140.00
  OriGene Technologies, Inc.

UltraMAB

TOP2A antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human lung tissue using anti-TOP2A mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA802385) Mouse IgG1 OTI2F8 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

TOP2A antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-TOP2A mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA802450) Mouse IgG1 OTI1D5 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

TOP2A antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human lung tissue using anti-TOP2A mouse monoclonal antibody. (TA802499) Dilution: 1:150 Mouse IgG1 OTIE1 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

TOP2A antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human lung tissue using anti-TOP2A mouse monoclonal antibody. (TA802505) Dilution: 1:150 Mouse IgG1 OTIB4 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

TOP2A antibody

Immunohistochemical staining of paraffin-embedded Human Ovary tissue within the normal limits using anti-TOP2A mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA802515) Mouse IgG1 OTI5E6 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

TOP2A antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-TOP2A mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH9.0, 120C for 3min, TA802516) Mouse IgG1 OTI2D12 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

TOP2A antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-TOP2A mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH9.0, 120C for 3min, TA802536) Mouse IgG1 OTI19D4 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

TOP2A antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human lung tissue using anti-TOP2A mouse monoclonal antibody. (TA802537) Dilution: 1:150 Mouse IgG1 OTIE11 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

TOP2A antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-TOP2A mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH9.0, 120C for 3min, TA802684) Mouse IgG1 OTI1D2 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

TOP2A antibody

Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG1 1E2 Hu E, ICC/IF, P, WB
50 µg / €530.00
  Acris Antibodies GmbH

TOP2A (C-term) antibody

Immunohistochemical detection on DNA Topoisomerase II alpha on paraffin embedded section of human stomach with AM26595AF-N Mouse IgG2a 1C5 Azide Free Hu F, ICC/IF, IP, P, WB
0.1 mg / €380.00
  Acris Antibodies GmbH

TOP2A antibody

Immunoperoxidase of monoclonal antibody to TOP2A on formalin-fixed paraffin-embedded human testis. [antibody concentration 3 ug/ml] Mouse IgG1 1E2 Purified Hu E, ICC/IF, P, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

TOP2A antibody

Western blot analysis of extracts from HepG2 cells, using TOP2A (Ab-1343) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TOP2A antibody

Western blot analysis of extracts from HT-29 cells, using TOP2A antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TOP2A antibody

Western blot analysis of extracts from LOVO cells, using TOP2A (Ab-1106) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

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