TOP2B antibody

Principal name

TOP2B antibody

Alternative names for TOP2B antibody

DNA topoisomerase 2-beta, DNA topoisomerase II beta isozyme

SwissProt ID

O42131 (Chick), Q02880 (Human), Q64511 (Mouse)

Gene ID

7155 (TOP2B), 21974 (Top2b)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Can (Canine), Mky (Monkey), Por (Porcine), Bov (Bovine), Eq (Equine), GP (Guinea Pig), Rb (Rabbit)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of TOP2B antibody

TOP2B is a D topoisomerase, an enzyme that controls and alters the topologic states of D during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsiol stress that occurs during D transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex D which allows the strands to pass through one another, thus altering the topology of D. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. This gene encodes a D topoisomerase, an enzyme that controls and alters the topologic states of D during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsiol stress that occurs during D transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex D which allows the strands to pass through one another, thus altering the topology of D. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, beta, is localized to chromosome 3 and the alpha form is localized to chromosome 17. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. Altertive splicing of this gene results in two transcript variants; however, the second variant has not yet been fully described. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additiol publications.

19 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

TOP2B antibody

  Rabbit anti-TOP2B polyclonal antibody  
Western blot analysis of HeLa cell lysates with anti-TOP2B antibody (1:200). This antibody, under reducing conditions, identified a band of ~180kDa in HeLa cell lysates. Rabbit Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TOP2B antibody

  Rabbit polyclonal Topoisomerase II beta antibody  
Western blot analysis of extracts from Jurkat cells, using Topoisomerase II Ã?antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TOP2B antibody

  Rabbit Polyclonal Anti-TOP2B Antibody  
WB Suggested Anti-TOP2B Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 62500; Positive Control: Human Stomach Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

TOP2B antibody

  Rabbit Polyclonal Anti-TOP2B Antibody  
WB Suggested Anti-TOP2B Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 1562500; Positive Control: Jurkat cell lysateTOP2B is supported by BioGPS gene expression data to be expressed in Jurkat Rabbit IgG Purified Can, Eq, GP, Hu, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

TOP2B antibody

  Rabbit Polyclonal Anti-TOP2B Antibody  
Western blot analysis on Jurkat cell lysate using TOP2B Antibody Rabbit IgG Purified Hu, Ms WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

TOP2B antibody

  Rabbit Polyclonal Anti-TOP2B Antibody  
Gel: 6%SDS-PAGE, Lysate: 40 ug, Lane 1-4: Raw264.7, Jurkat cells, K562 cells, hepg2 cells, Primary antibody: (TOP2B Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds Rabbit IgG Purified Hu, Ms E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TOP2B antibody

Western blot (WB) analysis of Topoisomerase II β antibody (Cat.-No.: AP06466PU-N) in extracts from Jurkat cells. Rabbit Aff - Purified Hu, Ms P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

TOP2B antibody

Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using TOP2B Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, P, WB
50 µg / €230.00
  Assay Biotech

TOP2B antibody

Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using TOP2B Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, P, WB
0.1 mg / €330.00
  Assay Biotech

CRISPR

Catalog No. Species Donor Vector  

TOP2B - human gene knockout kit via CRISPR

TOP2B - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

TOP2B - human gene knockout kit via CRISPR

TOP2B - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

TOP2B - human gene knockout kit via CRISPR

TOP2B - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

TOP2B - human gene knockout kit via CRISPR

TOP2B - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Top2b - mouse gene knockout kit via CRISPR

Top2b - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Top2b - mouse gene knockout kit via CRISPR

Top2b - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Top2b - mouse gene knockout kit via CRISPR

Top2b - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Top2b - mouse gene knockout kit via CRISPR

Top2b - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Top2b (GFP-tagged) - Mouse topoisomerase (DNA) II beta (Top2b), 200 uL, >10^7 TU/mL

Lenti ORF particles, Top2b (GFP-tagged) - Mouse topoisomerase (DNA) II beta (Top2b), 200 uL, >10^7 TU/mL  
200 µl / €2,590.00
  OriGene Technologies, Inc.

Lenti ORF particles, Top2b (Myc-DDK-tagged) - Mouse topoisomerase (DNA) II beta (Top2b), 200 uL, >10^7 TU/mL

Lenti ORF particles, Top2b (Myc-DDK-tagged) - Mouse topoisomerase (DNA) II beta (Top2b), 200 uL, >10^7 TU/mL  
200 µl / €2,340.00
  OriGene Technologies, Inc.

19 Item(s)

per page
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