TOPBP1 antibody

Principal name

TOPBP1 antibody

Alternative names for TOPBP1 antibody

KIAA0259, DNA topoisomerase 2-binding protein 1, DNA topoisomerase II-binding protein 1, DNA topoisomerase IIbeta-binding protein 1

SwissProt ID

Q6ZQF0 (Mouse), Q92547 (Human)

Gene ID

11073 (TOPBP1), 3611073 (IPR004639)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit, Mouse

Available applications

Immunoprecipitation (IP), PLA/Proximity ligation assay (PLA), Western blot / Immunoblot (WB), Enzyme Immunoassay (E)

Background of TOPBP1 antibody

TopBP1 is a phosphoprotein upregulated during the S phase of the cell cycle, which shares sequence homology with Dpb11 (S.cerevisiae), Rad4 (S.pombe), Mus101 (D. melanogaster) and Cut5 (Xenopus).
Studies indicate a role for TopBP1 in DNA replication through interaction with DNA polymerase E, in S phase DNA checkpoint control, and in DNA repair response to ionizing radiation damage. TopBP1 co-localizes with BRCA1 and is an important factor in minimising stalled replication forks and double-strand breaks (DSB), thereby maintaining genomic integrity.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

TOPBP1 antibody

Western blot analysis of extracts of various cell lines, using TOPBP1 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

TOPBP1 antibody

Detection of human TopBP1 in whole cell lysates of HeLa cells by immunoprecipitation and Western blotting using Rabbit anti Human TopBP1 (AP05759PU-N) Rabbit IgG Purified Hu IP, WB
50 µg / €330.00
  Acris Antibodies GmbH

TOPBP1 antibody

TOPBP1 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

TOPBP1 antibody

TOPBP1 Mouse IgG2a 6D12 Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

TOPBP1 antibody

Western Blot: TopBP1 Antibody [NB100-217] - Western blot detection of Human TopBP1, using NB100-217. Sample: Whole cell lysate (50 ug for WB) from HeLa cells. Rabbit Aff - Purified Hu IP, PLA, WB
0.1 mg / €440.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

TOPBP1

TOPBP1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

TOPBP1

TOPBP1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

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