TP53 / p53 antibody

Principal name

TP53 / p53 antibody

Alternative names for TP53 / p53 antibody

Cellular tumor antigen p53, Tumor suppressor p53, Phosphoprotein p53, NY-CO-13

SwissProt ID

P02340 (Mouse), P04637 (Human), P07193 (Xenla), P10360 (Chick), P10361 (Rat), P41685 (Felca), P51664 (Sheep), P67939 (Bovin), P79892 (Horse), Q29537 (Canfa), Q95330 (Rabit), Q9TUB2 (Pig), Q9WUR6 (Cavpo)

Gene ID

7157 (TP53), 22059 (Trp53), 397926 (tp53), 24842 (Tp53)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Prim (Primate), Bov (Bovine), Eq (Equine), Fe (Feline), Sh (Sheep), Can (Canine), Por (Porcine), Rb (Rabbit), Xen (Xenopus), Mky (Monkey), Av (Birds), Hst (Hamster), Frog, Ye (Yeast), GP (Guinea Pig), Chk (Chicken), Mam (Mammalia)

Available hosts

Mouse, Rabbit, Sheep, Rat, Goat

Available applications

Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Paraffin Sections (P), Frozen Sections (C), Enzyme Immunoassay (E), Flow Cytometry (F), Dot blot (Dot), ELISA (detection) (E(detection)), ChIP assay (ChIP), ELISA (capture) (E(capture)), Radioimmunoassay (R)

Background of TP53 / p53 antibody

TP53 acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. This gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and hence cause the loss of tumor suppressor activity. Alterations of this gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families with Li-Fraumeni syndrome. Multiple p53 variants due to alternative promoters and multiple alternative splicing have been found. These variants encode distinct isoforms, which can regulate p53 transcriptional activity.

General readings

Clone FPS315 is used in these references:
1. Pohler, E., et al., Mol. Cell Proteomics 3, 534-547 (2004)
2. Blaydes, J. P., et al., J. Biol. Chem. 276, 4699-4708 (2001)
3. Webley, K., et al., Mol. Cell Biol. 20, 2803-2808 (2000)
4. Blaydes, J. P., et al., Oncogene 19, 3829-3839 (2000)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

TP53 / p53 antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human pancreas tissue using anti-TP53 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA502870) Mouse IgG1 OTI5E2 Purified Hu, Mky, Ms F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

TP53 / p53 pSer392 antibody

Figure 1. Immunohistochemistry staining of Wild-type p53 expressed in Human Trophoblast (Paraffin-Embedded Sections): 1A: anti-p53 antibody (Total), 1B: anti-p53 antibody (Phospho Ser392). 
Note that some of total p53 positive nuclei are also FP3.2 (phospho p53) positive. Mouse IgG1 FP3.2 Aff - Purified Hu P, WB
0.1 mg / €260.00
  Acris Antibodies GmbH

TP53 / p53 pSer6 antibody

Western blot analysis of extracts from HT29 and Hela cells untreated or treated with UV using p53(Phospho-Ser6) Antibody Cat.-No AP08001PU Rabbit Aff - Purified Hu, Ms P, WB
50 µl / €240.00
  Acris Antibodies GmbH

TP53 / p53 (acetyl K382) antibody

MCF-7 cells were treated with 50 µM sodium butyrate and 2 nM actinomycin D for 8 hrs. MCF7 cell extract was resolved by electrophoresis (panel B) or immunoprecipitated with a p53 monoclonal (panel A) and resolved by electrophoresis. Proteins were transferred to nitrocellulose, and probed with Rabbit polyclonal Antibody against Acetylated p53 (Lys382). Lane 1: Untreated, control MCF-7 cells; Lane 2: Treated MCF-7 cells. Proteins were visualized using a Donkey anti-Rabbit secondary conjugated to HRP and a chemiluminescence detection system. Rabbit IgG Aff - Purified Hu WB
50 µl / €260.00
  Acris Antibodies GmbH

TP53 / p53 (16-25) antibody

Confocal Microscopy of Human HeLa cells using BM4079F p53 antibody (BP53-12, FITC). The expression of p53 protein was enhanced by intercalating reagent. Cells were fixed and permeabilized before incubation with the p53-FITC antibody. Photo provided by Dr. Hodny, Inst. of Experimental Medicine, Prague, Czech Republic. Mouse IgG2a BP53-12 FITC Hu, Prim ICC/IF
0.1 mg / €290.00
  Acris Antibodies GmbH

TP53 / p53 (16-25) antibody

Confocal Microscopy of Human HeLa cells using BM4079F p53 antibody (BP53-12, FITC). The expression of p53 protein was enhanced by intercalating reagent. Cells were fixed and permeabilized before incubation with the p53-FITC antibody. Photo provided by Dr. Hodny, Inst. of Experimental Medicine, Prague, Czech Republic. Mouse IgG2a BP53-12 Purified Hu, Prim C, E, ICC/IF, IP, P, WB
0.1 mg / €220.00
  Acris Antibodies GmbH

TP53 / p53 (Wild type + Mutant) antibody

Formalin-Paraffin Human colon stained with p53 Antibody Cat.-No SM2139P (Clone DO-7). Mouse IgG2b DO-7 Purified Bov, Hu, Mky C, F, ICC/IF, IP, P, WB
0.1 mg / €320.00
  Acris Antibodies GmbH

TP53 / p53 (Wild type + Mutant) antibody

Formalin-Paraffin Human colon stained with p53 Antibody Cat.-No SM2139P (Clone DO-7). Mouse IgG2b DO-7 Purified Bov, Hu, Mky C, F, ICC/IF, IP, P, WB
20 µg / €160.00
  Acris Antibodies GmbH

TP53 / p53 (Wild type + Mutant) antibody

Formalin-Paraffin Human colon stained with p53 Antibody Cat.-No SM2139P (Clone DO-7). Mouse IgG2b DO-7 Purified Bov, Hu, Mky C, F, ICC/IF, IP, P, WB
0.2 mg / €390.00
  Acris Antibodies GmbH

TP53 / p53 (Wild type + Mutant) antibody

Formalin-Fixed, Paraffin-Embedded colon Ca stained with p53 Antibody Cat.-No SM2139S (Clone DO-7). Mouse IgG2b DO-7 Supernatant Bov, Hu, Mky C, F, ICC/IF, IP, P, WB
1.0 ml / €360.00
  Acris Antibodies GmbH

TP53 / p53 (Wild type + Mutant) antibody

Formalin-Fixed, Paraffin-Embedded colon Ca stained with p53 Antibody Cat.-No SM2139S (Clone DO-7). Mouse IgG2b DO-7 Supernatant Bov, Hu, Mky C, F, ICC/IF, IP, P, WB
0.1 ml / €150.00
  Acris Antibodies GmbH

TP53 / p53 (Wild type + Mutant) antibody

Formalin-Fixed, Paraffin-Embedded colon Ca stained with p53 Antibody Cat.-No SM2139S (Clone DO-7). Mouse IgG2b DO-7 Supernatant Bov, Hu, Mky C, F, ICC/IF, IP, P, WB
0.5 ml / €280.00
  Acris Antibodies GmbH

TP53 / p53 antibody

Immunohistochemical staining of paraffin-embedded Human normal lung tissue and lung adenocarcinoma tissue using anti-TP53 mouse monoclonal antibody. (UM500049; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Mouse IgG1 UMAB55 Purified Hu ICC/IF, P, WB
0.1 ml / €468.00
  OriGene Technologies, Inc.

UltraMAB

TP53 / p53 antibody

Immunohistochemical staining of paraffin-embedded Human normal colon tissue and colorectal cancer tissue using anti-TP53 mouse monoclonal antibody. (UM500053; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Mouse IgG1 UMAB62 Purified Hu ICC/IF, P, WB
0.1 ml / €468.00
  OriGene Technologies, Inc.

UltraMAB

TP53 / p53 antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-TP53 Mouse monoclonal antibody.(Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.0) at 120C for 3 min, UM800098)(1:200) Mouse IgG1 UMAB206 Purified Hu P
0.1 ml / €468.00
  OriGene Technologies, Inc.

UltraMAB

TP53 / p53 antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-TP53 Mouse monoclonal antibody.(Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.0) at 120C for 3 min, UM800098)(1:200) Mouse IgG1 UMAB206 Purified Hu P
30 µl / €140.00
  OriGene Technologies, Inc.

UltraMAB

TP53 / p53 antibody

WB Suggested Anti-TP53 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:1562500; Positive Control: 293T cell lysate.TP53 is strongly supported by BioGPS gene expression data to be expressed in HEK293T Rabbit IgG Purified Hu ChIP, P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

TP53 / p53 antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human bladder tissue using anti-TP53 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA502780) Mouse IgG1 OTI3D5 Purified Hu F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

TP53 / p53 antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human bladder tissue using anti-TP53 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA502781) Mouse IgG1 OTI2C4 Purified Hu F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

TP53 / p53 antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human lung tissue using anti-TP53 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA502782) Mouse IgG1 OTI1C6 Purified Hu, Mky F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

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