TP53BP1 antibody

Principal name

TP53BP1 antibody

Alternative names for TP53BP1 antibody

p53-binding protein 1, p53BP1, 53BP1, Tumor suppressor p53-binding protein 1

SwissProt ID

P70399 (Mouse), Q12888 (Human)

Gene ID

7158 (TP53BP1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit, Mouse

Available applications

Flow Cytometry (F), Immunoprecipitation (IP), PLA/Proximity ligation assay (PLA), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Enzyme Immunoassay (E), Frozen Sections (C)

Background of TP53BP1 antibody

53BP1 (p53 binding protein 1) plays a key role in response to D damage, checkpoint sigling during mitosis and enhancing TP53-mediated transcriptiol activation. Origilly identified as p53's transcriptiol enhancing partner, 53BP1 now has been established as a substrate for ATM (ataxia telangiectasia mutated) sigling and that it relocalizes to discrete foci overlapping with gamma H2AX (phosphorylated histone H2AX); demarcating D double strand breaks (DSBs) sites following exposure to radiation. 53BP1 functions downstream of gamma H2AX-dependent hierarchy of proteins that collectively establish IRIF (ionizing radiation induced foci) at DSBs; this hierarchy includes Mre11/Rad50/NBS1 (MRN complex), ATM, MDC1, RNF8, RNF168 and HERC2. With the exception of ATM, whose function to generate gamma H2AX may be partially compensated by the activity of D-PK (D-dependent kise), all of these proteins are physically and functiolly required to recruit 53BP1 to the DSB site. Briefly, this process involves DSB recognition by MRN, ATM activation, gamma H2AX-formation, MDC1-recruitment, MRN-retention (leading to further ATM-activation and gamma H2AX spreading) and RNF8/RNF168/HERC2-mediated histone H2A and H2AX mono and poly-ubiquitition.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

TP53BP1 antibody

Immunohistochemistry: 53BP1 Antibody (6B3E10) [TA337093] - Immunohistochemical analysis of paraffin-embedded endometrial cancer tissues using TP53BP1 mouse mAb with DAB staining. Mouse IgG1 6B3E10 Purified Hu C, F, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TP53BP1 antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-TP53BP1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min, TA807033)(1:150) Mouse IgG1 OTI2H6 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

TP53BP1 antibody

Immunohistochemical staining of paraffin-embedded Human colon tissue within the normal limits using anti-TP53BP1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120°C for 3 min, TA807220)(1:150) Mouse IgG1 OTI5E1 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

TP53BP1 antibody

TP53BP1 foci in proliferating M059K cells were stained with TP53BP1 polyclonal antibody ( Cat # PAB12506 ) ; both normal and exposed to 10 Gy of IR and double-color immunofluorescence stained after 2 hours. Rabbit Hu, Ms F, ICC/IF, WB
0.1 ml / €470.00
  Abnova Taiwan Corp.

TP53BP1 (Super Novus Pack) antibody

Immunohistochemistry: 53BP1 antibody [NB100-304] - Placenta, Villi 40X Rabbit Aff - Purified Hu, Ms F, ICC/IF, P, WB
2 vials / €590.00
  Novus Biologicals Inc.

TP53BP1 antibody

Western Blot: 53BP1 Antibody - Figure 1 illustrates Western blot detection of 53BP1 (220 kDa) from untreated U2OS cell lysate using anti-53BP1. Rabbit Purified Hu, Ms C, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TP53BP1 antibody

Western Blot: 53BP1 Antibody - Detection of Human [deleted mouse] 53BP1 by Western Blot Sample: Whole cell lysate (20 ug/lane) from U2OS or 293T cells resolved on a 3 to 8% tris-acetate gel. Anti-53BP1 used at 0.5 ug/ml. Rabbit Purified Hu, Ms F, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TP53BP1 antibody

Western blot analysis of extracts from Jurkat cells and HUVEC cells, using 53BP1 (Ab-29) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TP53BP1 antibody

Immunohistochemistry analysis of paraffin-embedded human brain tissue using 53BP1 antibody.The picture on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

TP53BP1 antibody

Western blot analysis of extracts from A549 cells, using 53BP1 (Ab-6) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TP53BP1 antibody

Western blot analysis of extracts of A431 cell line, using TP53BP1 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

TP53BP1 antibody

Western blot analysis of 53BP1 expression in HUVEC cells Rabbit IgG Purified Hu, Ms WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

TP53BP1 antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TP53BP1 (RC218016, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-TP53BP1.(1:2000) Mouse IgG2b OTI12D4 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

TP53BP1 antibody

Western blot analysis of 53BP1 antibody (AP20288PU-N) in extracts from A549 cells. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

TP53BP1 antibody

TP53BP1 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

TP53BP1 antibody

Detection limit for recombinant GST tagged TP53BP1 is approximately 0.1ng/ml as a capture antibody. Mouse IgG1 1B9 Purified Hu E
0.1 mg / €370.00
  Abnova Taiwan Corp.

TP53BP1 antibody

Western blot analysis of TP53BP1 in untreated U-2 OS cell lysate with TP53BP1 polyclonal antibody ( Cat# PAB11994 ). Rabbit Hu, Ms ICC/IF, WB
0.1 ml / €470.00
  Abnova Taiwan Corp.

TP53BP1 antibody

Western blot analysis of human TP53BP1 using TP53BP1 polyclonal antibody ( Cat # PAB12507 ). Sample : Whole cell lysate ( 20 µg/lane ) from U-2 OS cells resolved on a 3 to 8% trisacetate gel. Rabbit Hu, Ms ICC/IF, WB
50 µl / €470.00
  Abnova Taiwan Corp.

TP53BP1 pSer6 antibody

Immunohistochemistry analysis of paraffin-embedded human heart, using 53BP1 (Phospho-Ser6) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
50 µg / €205.00
  Assay Biotech

TP53BP1 pSer6 antibody

Immunohistochemistry analysis of paraffin-embedded human heart, using 53BP1 (Phospho-Ser6) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €310.00
  Assay Biotech

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