TP53BP1 antibody

Principal name

TP53BP1 antibody

Alternative names for TP53BP1 antibody

p53-binding protein 1, p53BP1, 53BP1, Tumor suppressor p53-binding protein 1

SwissProt ID

P70399 (Mouse), Q12888 (Human)

Gene ID

7158 (TP53BP1), 27223 (Trp53bp1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Flow Cytometry (F), Paraffin Sections (P), Frozen Sections (C)

Background of TP53BP1 antibody

53BP1 (p53 binding protein 1) plays a key role in response to D damage, checkpoint sigling during mitosis and enhancing TP53-mediated transcriptiol activation. Origilly identified as p53's transcriptiol enhancing partner, 53BP1 now has been established as a substrate for ATM (ataxia telangiectasia mutated) sigling and that it relocalizes to discrete foci overlapping with gamma H2AX (phosphorylated histone H2AX); demarcating D double strand breaks (DSBs) sites following exposure to radiation. 53BP1 functions downstream of gamma H2AX-dependent hierarchy of proteins that collectively establish IRIF (ionizing radiation induced foci) at DSBs; this hierarchy includes Mre11/Rad50/NBS1 (MRN complex), ATM, MDC1, RNF8, RNF168 and HERC2. With the exception of ATM, whose function to generate gamma H2AX may be partially compensated by the activity of D-PK (D-dependent kise), all of these proteins are physically and functiolly required to recruit 53BP1 to the DSB site. Briefly, this process involves DSB recognition by MRN, ATM activation, gamma H2AX-formation, MDC1-recruitment, MRN-retention (leading to further ATM-activation and gamma H2AX spreading) and RNF8/RNF168/HERC2-mediated histone H2A and H2AX mono and poly-ubiquitition.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

TP53BP1 antibody

  Mouse Monoclonal 53BP1 Antibody (6B3E10)  
Western Blot: 53BP1 Antibody (6B3E10) [TA337093] - Western blot analysis using TP53BP1 mAb against HEK293 (1) and TP53BP1 (AA: 574-773)-hIgGFc transfected HEK293 (2) cell lysate. Mouse IgG1 6B3E10 Purified Hu C, F, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TP53BP1 antibody

  TP53BP1 mouse monoclonal antibody, clone OTI2H6 (formerly 2H6)  
Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-TP53BP1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min, TA807033)(1:150) Mouse IgG1 OTI2H6 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

TP53BP1 antibody

  TP53BP1 mouse monoclonal antibody, clone OTI5E1 (formerly 5E1)  
Immunohistochemical staining of paraffin-embedded Human colon tissue within the normal limits using anti-TP53BP1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120°C for 3 min, TA807220)(1:150) Mouse IgG1 OTI5E1 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

TP53BP1 antibody

TP53BP1 foci in proliferating M059K cells were stained with TP53BP1 polyclonal antibody ( Cat # PAB12506 ) ; both normal and exposed to 10 Gy of IR and double-color immunofluorescence stained after 2 hours. Rabbit Hu, Ms F, ICC/IF, WB
0.1 ml / €470.00
  Abnova Taiwan Corp.

TP53BP1 antibody

  Rabbit Polyclonal 53BP1 Antibody  
Western Blot: 53BP1 Antibody - Figure 1 illustrates Western blot detection of 53BP1 (220 kDa) from untreated U2OS cell lysate using anti-53BP1. Rabbit Purified Hu, Ms C, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TP53BP1 antibody

  Rabbit Polyclonal 53BP1 Antibody  
Western Blot: 53BP1 Antibody - Detection of Human [deleted mouse] 53BP1 by Western Blot Sample: Whole cell lysate (20 ug/lane) from U2OS or 293T cells resolved on a 3 to 8% tris-acetate gel. Anti-53BP1 used at 0.5 ug/ml. Rabbit Purified Hu, Ms F, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TP53BP1 antibody

  Rabbit polyclonal 53BP1 (Ab-29) antibody  
Western blot analysis of extracts from Jurkat cells and HUVEC cells, using 53BP1 (Ab-29) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TP53BP1 antibody

  Rabbit polyclonal anti-53BP1 antibody  
Immunohistochemistry analysis of paraffin-embedded human brain tissue using 53BP1 antibody.The picture on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

TP53BP1 antibody

  Rabbit polyclonal 53BP1 (Ser25) antibody(Phospho-specific)  
Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue using 53BP1 (Phospho-Ser25) antibody.The picture on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, ICC/IF, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

TP53BP1 antibody

  Rabbit anti-TP53BP1 Polyclonal Antibody  
Western blot analysis of extracts of A431 cell line, using TP53BP1 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

TP53BP1 antibody

  Rabbit Polyclonal Anti-53BP1 Antibody  
Western blot analysis of 53BP1 expression in HUVEC cells Rabbit IgG Purified Hu, Ms WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

TP53BP1 antibody

  TP53BP1 mouse monoclonal antibody, clone OTI12D4 (formerly 12D4)  
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TP53BP1 (RC218016, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-TP53BP1.(1:2000) Mouse IgG2b OTI12D4 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

TP53BP1 antibody

Western blot analysis of 53BP1 antibody (AP20288PU-N) in extracts from A549 cells. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

TP53BP1 antibody

TP53BP1 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

TP53BP1 antibody

Detection limit for recombinant GST tagged TP53BP1 is approximately 0.1ng/ml as a capture antibody. Mouse IgG1 1B9 Purified Hu E
0.1 mg / €370.00
  Abnova Taiwan Corp.

TP53BP1 antibody

Western blot analysis of TP53BP1 in untreated U-2 OS cell lysate with TP53BP1 polyclonal antibody ( Cat# PAB11994 ). Rabbit Hu, Ms ICC/IF, WB
0.1 ml / €470.00
  Abnova Taiwan Corp.

TP53BP1 antibody

Western blot analysis of human TP53BP1 using TP53BP1 polyclonal antibody ( Cat # PAB12507 ). Sample : Whole cell lysate ( 20 µg/lane ) from U-2 OS cells resolved on a 3 to 8% trisacetate gel. Rabbit Hu, Ms ICC/IF, WB
50 µl / €470.00
  Abnova Taiwan Corp.

TP53BP1 pSer6 antibody

Immunohistochemistry analysis of paraffin-embedded human heart, using 53BP1 (Phospho-Ser6) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
50 µg / €205.00
  Assay Biotech

TP53BP1 pSer6 antibody

Immunohistochemistry analysis of paraffin-embedded human heart, using 53BP1 (Phospho-Ser6) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €310.00
  Assay Biotech

TP53BP1 pSer25 antibody

Immunohistochemistry analysis of paraffin-embedded human colon carcinoma, using 53BP1 (Phospho-Ser25) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, P
50 µg / €205.00
  Assay Biotech

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