TP53I3 antibody

Principal name

TP53I3 antibody

Alternative names for TP53I3 antibody

p53-induced gene 3 protein, PIG3, Tumor protein p53-inducible protein 3, Quinone oxidoreductase PIG3

SwissProt ID

Q53FA7 (Human)

Gene ID

9540 (TP53I3)

Available reactivities

Hu (Human), Mky (Monkey), Bov (Bovine), Can (Canine), Eq (Equine), Por (Porcine), Rb (Rabbit), Rt (Rat)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), EPair for Elisa (EPair), Enzyme Immunoassay (E), Immunoprecipitation (IP), Flow Cytometry (F), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of TP53I3 antibody

P53 Inducible Gene-3 (PIG-3) may be a long-lived reporter, which may be useful for detecting transient activation of p53. The p53 tumor suppressor is the most commonly mutated gene in human cancers. The p53 protein, which is stabilized in response to different biological checkpoints, is activated by DNA damage, hypoxia, viral infection, or oncogene activation resulting in efects such as cell cycle arrest, apoptosis, senescence, differentiation, and antiangiogenesis. Other genes also implicated in the downstream effects as a result of p53 activation are: p21WAF1, GADD45, 14-3-3, bax, Fas/APO1, KILLER/ DR5, Tsp1, IGF-BP3 and others. The p53-inducible gene 3 (PIG3), was recently identified in a screen for genes induced by p53 before the onset of apoptosis. PIG3 shares significant homology with the oxidoreductases from several species. PIG3 protein is localized to the cytoplasm and induced in primary, non-transformed, and transformed cell cultures after exposure to genotoxic agents. The induction of PIG3 by p53 occurrs with delayed kinetics as compared with other p53 downstream targets, such as p21 and MDM2. PIG3 levels are increased during p53-mediated growth arrest. Elevated levels of PIG3 are maintained in cells that resume cycling in the absence of ectopic p53 expression.

General readings

Flatt PM. et al. (2000) Cancer Lett. 156(1):63-72.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

TP53I3 antibody

Figure 1.Western blot analysis using AM05278PU-N PIG-3 antibody on Jurkat lysate at 10 µg/ml. Mouse IgG1 10A2 Purified Hu WB
0.1 mg / €370.00
  Acris Antibodies GmbH

TP53I3 antibody

Western blot using anti-PIG3 antibody on RKO cells transfected with pCEP4 without insert (1), transfected with pCEP4-PIG3 (2), under control conditions (3) and treated with adriamycin to activate wild-type p53 (4). Also used on MCF-7 cells transfected with pCEP4 without insert (5) and pCEP4-PIG3 (6). Rabbit IgG Purified Hu WB
0.1 mg / €370.00
  Acris Antibodies GmbH

TP53I3 antibody

  TP53I3 (PIG3) mouse monoclonal antibody, clone OTI3B11 (formerly 3B11)  
Immunohistochemical staining of paraffin-embedded Carcinoma of Human thyroid tissue using anti-TP53I3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA503656) Mouse IgG1 OTI3B11 Purified Hu P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

TP53I3 antibody

  Rabbit Polyclonal PIG3 Antibody  
Immunohistochemical staining of paraffin-embedded Human prostate tissue using anti-TP53I3 rabbit polyclonal antibody. (TA590395) Rabbit IgG Purified Hu, Mky E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

TP53I3 antibody

  Rabbit Polyclonal antibody to PIG3 (tumor protein p53 inducible protein 3)  
Sample (30 ug of whole cell lysate). A: Hep G2 . 10% SDS PAGE. TA308561 diluted at 1:1000. Rabbit IgG Aff - Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TP53I3 antibody

  Rabbit Polyclonal Anti-TP53I3 Antibody  
WB Suggested Anti-TP53I3 Antibody; Titration: 1.0 ug/ml; Positive Control: MCF7 Whole Cell Rabbit IgG Purified Bov, Can, Eq, Hu, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

TP53I3 antibody

  TP53I3 (PIG3) mouse monoclonal antibody, clone OTI3E3 (formerly 3E3)  
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TP53I3 (RC224067, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-TP53I3. Mouse IgG1 OTI3E3 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

TP53I3 (1-332) antibody

Flow cytometry analysis of TP53I3 in A549 cell line, staining at 2 - 5ug for 1x106 cells (red line). The secondary antibody used goat anti mouse IgG Alexa fluor 488 conjugate. Isotype control antibody was mouse IgG (black line). Mouse IgG2a AT1C9 Purified Hu E, F, WB
0.1 ml / €310.00
  Acris Antibodies GmbH

TP53I3 (1-332) antibody

Flow cytometry analysis of TP53I3 in A549 cell line, staining at 2 - 5ug for 1x106 cells (red line). The secondary antibody used goat anti mouse IgG Alexa fluor 488 conjugate. Isotype control antibody was mouse IgG (black line). Mouse IgG2a AT1C9 Purified Hu E, F, WB
50 µl / €220.00
  Acris Antibodies GmbH

TP53I3 antibody

Western blot (WB) analysis of PIG3 antibody (Cat.-No.: AP06743PU-N) in extracts from 293 cells. Rabbit Aff - Purified Hu WB
0.1 mg / €350.00
  Acris Antibodies GmbH

TP53I3 antibody

Western blot analysis of extracts from 293 cells, using QORX Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, WB
50 µg / €230.00
  Assay Biotech

TP53I3 antibody

Western blot analysis of extracts from 293 cells, using QORX Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, WB
0.1 mg / €330.00
  Assay Biotech

CRISPR

Catalog No. Species Donor Vector  

TP53I3 - human gene knockout kit via CRISPR

TP53I3 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

TP53I3 - human gene knockout kit via CRISPR

TP53I3 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

TP53I3 - human gene knockout kit via CRISPR

TP53I3 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

TP53I3 (transcript variant 1)

  Recombinant protein of human tumor protein p53 inducible protein 3 (TP53I3), transcript variant 1  
TP53I3 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

TP53I3 (transcript variant 2)

  Recombinant protein of human tumor protein p53 inducible protein 3 (TP53I3), transcript variant 2  
TP53I3 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

TP53I3 (1-332, His-tag)

TP53I3 Human Purified > 90 % by SDS - PAGE E. coli
0.5 mg / €670.00
  Acris Antibodies GmbH

TP53I3 (1-332, His-tag)

TP53I3 Human Purified > 90 % by SDS - PAGE E. coli
0.1 mg / €250.00
  Acris Antibodies GmbH

Lysates

Catalog No.    

TP53I3 overexpression lysate

TP53I3 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

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