TP53I3 antibody

Principal name

TP53I3 antibody

Alternative names for TP53I3 antibody

p53-induced gene 3 protein, PIG3, Tumor protein p53-inducible protein 3, Quinone oxidoreductase PIG3

SwissProt ID

Q53FA7 (Human)

Gene ID

9540 (TP53I3)

Available reactivities

Hu (Human), Mky (Monkey), Bov (Bovine), Can (Canine), Eq (Equine), Por (Porcine), Rb (Rabbit), Rt (Rat)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), EPair for Elisa (EPair), Enzyme Immunoassay (E), Immunoprecipitation (IP), Flow Cytometry (F), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of TP53I3 antibody

P53 Inducible Gene-3 (PIG-3) may be a long-lived reporter, which may be useful for detecting transient activation of p53. The p53 tumor suppressor is the most commonly mutated gene in human cancers. The p53 protein, which is stabilized in response to different biological checkpoints, is activated by DNA damage, hypoxia, viral infection, or oncogene activation resulting in efects such as cell cycle arrest, apoptosis, senescence, differentiation, and antiangiogenesis. Other genes also implicated in the downstream effects as a result of p53 activation are: p21WAF1, GADD45, 14-3-3, bax, Fas/APO1, KILLER/ DR5, Tsp1, IGF-BP3 and others. The p53-inducible gene 3 (PIG3), was recently identified in a screen for genes induced by p53 before the onset of apoptosis. PIG3 shares significant homology with the oxidoreductases from several species. PIG3 protein is localized to the cytoplasm and induced in primary, non-transformed, and transformed cell cultures after exposure to genotoxic agents. The induction of PIG3 by p53 occurrs with delayed kinetics as compared with other p53 downstream targets, such as p21 and MDM2. PIG3 levels are increased during p53-mediated growth arrest. Elevated levels of PIG3 are maintained in cells that resume cycling in the absence of ectopic p53 expression.

General readings

Flatt PM. et al. (2000) Cancer Lett. 156(1):63-72.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

TP53I3 antibody

  Rabbit Polyclonal PIG3 Antibody  
Immunohistochemical staining of paraffin-embedded Human prostate tissue using anti-TP53I3 rabbit polyclonal antibody. (TA590395) Rabbit IgG Purified Hu, Mky E, P, WB
0.1 mg / €409.00
  OriGene Technologies, Inc.

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