TPD52 antibody

Principal name

TPD52 antibody

Alternative names for TPD52 antibody

Tumor protein D52

SwissProt ID

P55327 (Human), Q62393 (Mouse), Q95212 (Rabit)

Gene ID

7163 (TPD52)

Available reactivities

Hu (Human), Can (Canine), Bov (Bovine), Chk (Chicken), Ms (Mouse), Rb (Rabbit), Rt (Rat), Ze (Zebrafish), African clawed frog

Available hosts

Mouse, Goat, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), Dot blot (Dot), Paraffin Sections (P)

Background of TPD52 antibody

The tumor protein D52 was found to be associated with immunoglobulin super-family receptor translocation-associated 1 (IRTA1) receptor in the b cells of normal lymphohematopietic tissue. The 28kDa protein TPD52 expression was also noted in only in normal and neoplastic epithelia. Unlike other B-cell associated molecules (Pax5, CD19, CD79a, CD20 and CD22) which are down regulated during differentiation form B-cell to plasma cells, the TPD52 expression reached maximum levcel at the plasma cell stage (1). TPD52 expression in thiel myeloma cell line was localized with Annexin IV in a calcium dependent manner suggesting that TPD52 and Annexin may regulate the secretory processes as has been observed in pancreatic acinar cells (1). The elevated expression of TPD52 was also found in lung and breast carcinomas where it was suggested to play a role in calcium mediated signal transduction and cell proliferation. The TPD52 was differentially expressed in fetal and adult tissues, in adult high expression levels were noted in brain, kidney, prostate, pancreas and intestine and at very low levels in lungs, liver, hematopoietic cells and gonads. During development the protein is expressed in epithelium of the intestine, stomach, olfactory and neuronal layers of retina (2). TPD52 expression was differential in Normal to low levels of this protein was found in The TPD52 protein represent a family of proteins with predicted coil-coil domain that demonstrate homo and heteromeric interactions with other tumor protein homologs hD52, hD53 and hD54 (3).
TPD52 was localized on chromosome 8p13 region. There are at least 3 isoforms reported in literature (TPD52 isoform 1, 2 and 3) with significant homology, the differences are in alternate splicing of exons. The tumor protein related family members are also implicated in cell proliferation, apoptosis and vesicle trafficking. The TPD52 is a 224 amino acid, 28 kDa protein (TPD52 isofrom 1). A testis specific tumor protein (hD55) was identified by yeast-two hybrids and GST pull-down assays which suggest that hD55 interacts with TPD52, hD53 and hD54 and itself. The hD55 is expressed 5-6 fold excess amount in adult testis than in fetal testis suggesting its role in spermatogensis (4).

General readings

Byrne JA, Balleine RL, Schoenberg Fejzo M, Mercieca J, Chiew YE, Livnat Y, St Heaps L, Peters GB, Byth K, Karlan BY, Slamon DJ, Harnett P, Defazio A.
Tumor protein D52 (TPD52) is overexpressed and a gene amplification target in ovarian cancer.
Int J Cancer. 2005 Dec 20;117(6):1049-54.
PMID: 15986428

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

TPD52 (C-term) antibody

TA303278 (1µg/ml) staining of Human Lymph Node lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Can, Hu E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

TPD52 antibody

Immunohistochemistry analysis of paraffin-embedded human brain tissue, using TPD52 antibody.The picture on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

TPD52 Control Peptide

TPD52
0.25 mg / €250.00
  Acris Antibodies GmbH

TPD52 (N-term) antibody

Western blot of TPD52 antibody with AP10354PU-N (Right lane) and AP10355PU-N  (Left lane) at 1/750 dilution Rabbit IgG Aff - Purified Hu Dot, E, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

TPD52 Control Peptide

TPD52
0.25 mg / €250.00
  Acris Antibodies GmbH

TPD52 antibody

Western blot of TPD52 antibody with AP10354PU-N (Right lane) and AP10355PU-N (Left lane) at 1/750 dilution Rabbit IgG Aff - Purified Hu Dot, E, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

TPD52 antibody

Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit IgG Aff - Purified Hu, Ms E, P
50 µg / €470.00
  Acris Antibodies GmbH

TPD52 antibody

TPD52 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

TPD52 antibody

Immunofluorescence of purified MaxPab antibody to TPD52 on HeLa cell. [antibody concentration 10 ug/ml] Mouse Purified Hu E(detection), ICC/IF, WB
50 µg / €370.00
  Abnova Taiwan Corp.

TPD52 antibody

TPD52 Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

TPD52 antibody

Western Blot analysis of TPD52 expression in transfected 293T cell line (H00007163-T03) by TPD52 MaxPab polyclonal antibody.

Lane 1: TPD52 transfected lysate(20.24 KDa).
Lane 2: Non-transfected lysate. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

TPD52 antibody

Western Blot analysis of TPD52 expression in transfected 293T cell line by TPD52 monoclonal antibody (M01), clone 1B6.

Lane 1: TPD52 transfected lysate(19.863 KDa).
Lane 2: Non-transfected lysate. Mouse IgG2b 1B6 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

TPD52 antibody

TPD52 polyclonal antibody ( Cat # PAB7359 ) ( 1 µg/ml ) staining of human lymph node lysate ( 35 µg protein in RIPA buffer ) . Primary incubation was 1 hour. Detected by chemiluminescence. Goat Hu E, WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

TPD52 antibody

Immunohistochemistry analysis of paraffin-embedded human brain tissue, using TPD52 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, P
50 µg / €205.00
  Assay Biotech

TPD52 antibody

Immunohistochemistry analysis of paraffin-embedded human brain tissue, using TPD52 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, P
0.1 mg / €310.00
  Assay Biotech

TPD52 (C-term) antibody

TPD52 Rabbit Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

TPD52 antibody

Mouse retina; . Application: Immunofluorescence. Species+tissue/cell type: Mouse retina. Primary antibody dilution: 1:200. Secondary antibody: Goat anti-rabbit Alexafluor 568. Secondary antibody dilution: 1:200 - See more at: http://www.avivasysbio.com/tpd52-antibody-middle-region-arp48272-p050.html#sthash.3zY1gILg.dpuf; TPD52 antibody - middle region (ARP48272_P050) in Mouse retina cells using Immunohistochemistry Rabbit Aff - Purified African clawed frog, Bov, Chk, Hu, Ms, Rb, Rt, Ze WB
50 µg / €350.00
  AVIVA Systems Biology

TPD52 antibody

NBP1-06090 (1ug/ml) staining of Human Lymph Node lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat IgG Aff - Purified Hu E, WB
0.1 mg / €400.00
  Novus Biologicals Inc.

TPD52 antibody

Western Blot: TPD52 Antibody [NBP1-56457] - This Anti-TPD52 antibody was used in Western Blot of Jurkat tissue lysate at a concentration of 1ug/ml. Rabbit Aff - Purified Hu, Ms, Rt WB
50 µg / €440.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

TPD52 (transcript variant 3)

TPD52 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

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