TPD52 antibody

Principal name

TPD52 antibody

Alternative names for TPD52 antibody

Tumor protein D52

SwissProt ID

P55327 (Human), Q62393 (Mouse), Q95212 (Rabit)

Gene ID

7163 (TPD52), 21985 (Tpd52)

Available reactivities

Hu (Human), Bov (Bovine), Chk (Chicken), Ms (Mouse), Rb (Rabbit), Rt (Rat), Ze (Zebrafish), African clawed frog, Can (Canine), Eq (Equine), GP (Guinea Pig), Por (Porcine)

Available hosts

Rabbit, Mouse, Goat

Available applications

Dot blot (Dot), Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of TPD52 antibody

The tumor protein D52 was found to be associated with immunoglobulin super-family receptor translocation-associated 1 (IRTA1) receptor in the b cells of normal lymphohematopietic tissue. The 28kDa protein TPD52 expression was also noted in only in normal and neoplastic epithelia. Unlike other B-cell associated molecules (Pax5, CD19, CD79a, CD20 and CD22) which are down regulated during differentiation form B-cell to plasma cells, the TPD52 expression reached maximum levcel at the plasma cell stage (1). TPD52 expression in thiel myeloma cell line was localized with Annexin IV in a calcium dependent manner suggesting that TPD52 and Annexin may regulate the secretory processes as has been observed in pancreatic acinar cells (1). The elevated expression of TPD52 was also found in lung and breast carcinomas where it was suggested to play a role in calcium mediated signal transduction and cell proliferation. The TPD52 was differentially expressed in fetal and adult tissues, in adult high expression levels were noted in brain, kidney, prostate, pancreas and intestine and at very low levels in lungs, liver, hematopoietic cells and gonads. During development the protein is expressed in epithelium of the intestine, stomach, olfactory and neuronal layers of retina (2). TPD52 expression was differential in Normal to low levels of this protein was found in The TPD52 protein represent a family of proteins with predicted coil-coil domain that demonstrate homo and heteromeric interactions with other tumor protein homologs hD52, hD53 and hD54 (3).
TPD52 was localized on chromosome 8p13 region. There are at least 3 isoforms reported in literature (TPD52 isoform 1, 2 and 3) with significant homology, the differences are in alternate splicing of exons. The tumor protein related family members are also implicated in cell proliferation, apoptosis and vesicle trafficking. The TPD52 is a 224 amino acid, 28 kDa protein (TPD52 isofrom 1). A testis specific tumor protein (hD55) was identified by yeast-two hybrids and GST pull-down assays which suggest that hD55 interacts with TPD52, hD53 and hD54 and itself. The hD55 is expressed 5-6 fold excess amount in adult testis than in fetal testis suggesting its role in spermatogensis (4).

General readings

Byrne JA, Balleine RL, Schoenberg Fejzo M, Mercieca J, Chiew YE, Livnat Y, St Heaps L, Peters GB, Byth K, Karlan BY, Slamon DJ, Harnett P, Defazio A.
Tumor protein D52 (TPD52) is overexpressed and a gene amplification target in ovarian cancer.
Int J Cancer. 2005 Dec 20;117(6):1049-54.
PMID: 15986428

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

TPD52 (C-term) antibody

  Goat Polyclonal Antibody against TPD52  
TA303278 (1µg/ml) staining of Human Lymph Node lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Can, Hu E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

TPD52 antibody

  Rabbit polyclonal anti-TPD52 antibody  
Immunohistochemistry analysis of paraffin-embedded human brain tissue, using TPD52 antibody.The picture on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

TPD52 antibody

  Rabbit Polyclonal Anti-TPD52 Antibody  
WB Suggested Anti-TPD52 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 312500; Positive Control: THP-1 cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

TPD52 antibody

  Rabbit Polyclonal Anti-TPD52 Antibody  
WB Suggested Anti-TPD52 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 312500; Positive Control: Jurkat cell lysate.TPD52 is strongly supported by BioGPS gene expression data to be expressed in Human Jurkat cells Rabbit IgG Purified Bov, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

TPD52 antibody

  Rabbit Polyclonal Anti-TPD52 Antibody  
TPD52 Rabbit IgG Purified Hu E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TPD52 antibody

Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit IgG Aff - Purified Hu, Ms E, P
50 µg / €470.00
  Acris Antibodies GmbH

TPD52 antibody

Immunohistochemistry analysis of paraffin-embedded human brain tissue, using TPD52 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, P
50 µg / €230.00
  Assay Biotech

TPD52 antibody

Immunohistochemistry analysis of paraffin-embedded human brain tissue, using TPD52 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, P
0.1 mg / €330.00
  Assay Biotech

CRISPR

Catalog No. Species Donor Vector  

TPD52 - human gene knockout kit via CRISPR

TPD52 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

TPD52 - human gene knockout kit via CRISPR

TPD52 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

TPD52 - human gene knockout kit via CRISPR

TPD52 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

TPD52 - human gene knockout kit via CRISPR

TPD52 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Tpd52 - mouse gene knockout kit via CRISPR

Tpd52 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Tpd52 - mouse gene knockout kit via CRISPR

Tpd52 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Tpd52 - mouse gene knockout kit via CRISPR

Tpd52 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Tpd52 - mouse gene knockout kit via CRISPR

Tpd52 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

TPD52 (transcript variant 3)

  Recombinant protein of human tumor protein D52 (TPD52), transcript variant 3  
TPD52 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, TPD52 (mGFP-tagged)-Human tumor protein D52 (TPD52), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, TPD52 (mGFP-tagged)-Human tumor protein D52 (TPD52), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, TPD52 (mGFP-tagged) - Human tumor protein D52 (TPD52), transcript variant 3, 200 uL, >10^7 TU/mL

Lenti ORF particles, TPD52 (mGFP-tagged) - Human tumor protein D52 (TPD52), transcript variant 3, 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, TPD52 (Myc-DDK-tagged)-Human tumor protein D52 (TPD52), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, TPD52 (Myc-DDK-tagged)-Human tumor protein D52 (TPD52), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

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