TRAC antibody

Principal name

TRAC antibody

Alternative names for TRAC antibody

T-cell receptor alpha chain C region

SwissProt ID

P01848 (Human), P01849 (Mouse)

Ncbi ID

9606, 10090

Available reactivities

Hu (Human), Ms (Mouse)

Available hosts

Mouse, Rabbit

Available applications

Frozen Sections (C), Immunoprecipitation (IP), Paraffin Sections (P), Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Flow Cytometry (F), Neutralisation (NEUT)

Background of TRAC antibody

T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor beta locus. The beta locus includes V (variable), J (joining), diversity (D), and C (constant) segments. During T cell development, the beta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Several V segments and one J segment of the beta locus are known to be incapable of encoding a protein and are considered pseudogenes. The beta locus also includes eight trypsinogen genes, three of which encode functional proteins and five of which are pseudogenes. Chromosomal abnormalities involving the T-cell receptor beta locus have been associated with T-cell lymphomas.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

T Cell Receptor (TCR) alpha/beta (alpha chain) antibody

T Cell Receptor (TCR) alpha/beta Mouse IgG2a 3A8 Purified Hu C, IP
0.1 mg / €440.00
  Acris Antibodies GmbH

T Cell Receptor (TCR) alpha/beta (alpha chain) antibody

T Cell Receptor (TCR) alpha/beta Mouse IgG2a 3A8 Purified Hu C, IP
50 µg / €380.00
  Acris Antibodies GmbH

T Cell Receptor (TCR) alpha/beta (alpha chain) antibody

T Cell Receptor (TCR) alpha/beta Mouse IgG2a 3A8 Aff - Purified Hu C, IP, P
50 µg / €420.00
  Novus Biologicals Inc.

TRAC antibody

Western Blot analysis of TRA@ expression in transfected 293T cell line (H00006955-T01) by TRA@ MaxPab polyclonal antibody.

Lane 1: TRA@ transfected lysate(32.56 KDa).
Lane 2: Non-transfected lysate. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

TRAC antibody

TRAC Mouse IgG2a 4H8 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

TRAC antibody

Western blot analysis of TRA@ expression in Jurkat cell lysate. Rabbit Hu C, IP, WB
0.1 mg / €470.00
  Abnova Taiwan Corp.

TRAC antibody

TRAC Mouse IgG2a KJ1298 Purified Ms E, F, IP, NEUT
0.1 ml / €400.00
  Immuquest

Lysates

Catalog No.    

TRA 293T Cell Transient Overexpression Lysate(Denatured)

TRA 293T Cell Transient Overexpression Lysate(Denatured)  
0.1 ml / €270.00
  Abnova Taiwan Corp.

TRA@ 293T Cell Transient Overexpression Lysate(Denatured)

TRA@ 293T Cell Transient Overexpression Lysate(Denatured)  
0.1 ml / €270.00
  Abnova Taiwan Corp.

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