Transducin beta chain 1 / GNB1 antibody

Principal name

Transducin beta chain 1 / GNB1 antibody

Alternative names for Transducin beta chain 1 / GNB1 antibody

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

SwissProt ID

P54311 (Rat), P62871 (Bovin), P62872 (Canfa), P62873 (Human), P62874 (Mouse)

Gene ID

2782 (GNB1), 8945 (BTRC)

Available reactivities

Sh (Sheep), Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Dros (Drosophila), Can (Canine), African clawed frog, Eq (Equine), GP (Guinea Pig), Rb (Rabbit)

Available hosts

Rabbit

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Frozen Sections (C)

Background of Transducin beta chain 1 / GNB1 antibody

Vision involves the conversion of light into electrochemical signals that are processed by the retina and subsequently sent to and interpreted by the brain. The process of converting light into an electrochemical signal begins when the membrane-bound protein, rhodopsin, absorbs light within the retina. Photoexcitation of rhodopsin causes the cytoplasmic surface of the protein to become catalytically active. In the active state, rhodopsin activates transducin, a GTP binding protein. Once activated, transducin promotes the hydrolysis of cGMP by phosphodiesterase (PDE). The decrease of intracellular cGMP concentration causes the ion channels within the outer segment of the rod or cone to close, thus causing membrane hyperpolarization and, eventually, signal transmission. Rhodopsin activity is believed to be shut off by phosphorylation followed by binding of the soluble protein, arrestin.
Transducin, once activated by rhodopsin, promotes the hydrolysis of cGMP by PDE. The subunit composition of transducin differs between different photoreceptor cells. Rod transducin consists of rod transducin alpha (Tr alpha), T beta, and T gamma. Cone transducin is composed of cone transducin alpha (Tc alpha), T beta and T gamma. Differential transducin subunit composition of transducin is believed to be responsible for the different light sensitivities between photoreceptive cells.

General readings

General / background references:Calvert PD et al. Phototransduction in transgenic mice after targeted deletion of the rod transducin alpha -subunit. Proc Natl Acad Sci U S A 97:13913-8 (2000). PubMed PMID: 11095744
Baylor D How photons start vision. Proc Natl Acad Sci U S A 93:560-5 (1996). PubMed PMID: 8570595

12 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Transducin beta chain 1 / GNB1 antibody

WB Suggested Anti-GNB1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 1562500; Positive Control: Human brain Rabbit IgG Purified Bov, Eq, GP, Hu, Ms, Rb WB
50 µg / €325.00
  OriGene Technologies, Inc.

Transducin beta chain 1 / GNB1 antibody

WB Suggested Anti-GNB1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 2500; Positive Control: Human brain Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

Transducin beta chain 1 / GNB1 antibody

Human Brain; WB Suggested Anti-GNB1 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:1562500. Positive Control: Human brain; GNB1 antibody - N-terminal region (ARP54637_P050) in Human Brain cells using Western Blot Rabbit Aff - Purified Can, Hu, Ms, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

Transducin beta chain 1 / GNB1 antibody

Human Brain; WB Suggested Anti-GNB1 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:2500. Positive Control: Human brain; GNB1 antibody - C-terminal region (ARP54638_P050) in Human Brain cells using Western Blot Rabbit Aff - Purified African clawed frog, Bov, Can, Hu, Ms, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

Transducin beta chain 1 / GNB1 antibody

Transducin beta chain 1 / GNB1 Rabbit Serum Hu, Ms, Rt C, P, WB
0.1 ml / €400.00
  Novus Biologicals Inc.

Transducin beta chain 1 / GNB1 antibody

Western Blot: Transducin beta Antibody [NB120-3433] - Figure 1 shows a Western blot of Tr beta on sheep retinal extracts using NB120-3433. Rabbit IgG Aff - Purified Bov, Dros, Hu, Ms, Sh WB
0.1 mg / €400.00
  Novus Biologicals Inc.

Transducin beta chain 1 / GNB1 antibody

Western Blot: GNB1 Antibody [NBP1-55307] - This Anti-GNB1 antibody was used in Western Blot of Fetal Brain tissue lysate at a concentration of 1ug/ml. Rabbit Aff - Purified Can, Hu, Ms, Rt WB
50 µg / €440.00
  Novus Biologicals Inc.

Transducin beta chain 1 / GNB1 antibody

Western Blot: GNB1 Antibody [NBP1-55308] - This Anti-GNB1 antibody was used in Western Blot of Fetal Brain tissue lysate at a concentration of 1ug/ml. Rabbit Aff - Purified Can, Hu, Ms, Rt WB
50 µg / €440.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Transducin beta chain 1 / GNB1 (1-340, His-tag)

Transducin beta chain 1 / GNB1 Human Purified > 85 % by SDS - PAGE E. coli
0.25 mg / €940.00
  Acris Antibodies GmbH

Transducin beta chain 1 / GNB1 (1-340, His-tag)

Transducin beta chain 1 / GNB1 Human Purified > 85 % by SDS - PAGE E. coli
50 µg / €370.00
  Acris Antibodies GmbH

Transducin beta chain 1 / GNB1

Transducin beta chain 1 / GNB1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

Transducin beta chain 1 / GNB1

Transducin beta chain 1 / GNB1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

12 Item(s)

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