Transglutaminase-2 (TGM2) antibody

Principal name

Transglutaminase-2 (TGM2) antibody

Alternative names for Transglutaminase-2 (TGM2) antibody

TGase C, TGase-H, Tissue transglutaminase, Protein-glutamine gamma-glutamyltransferase 2

SwissProt ID

P21980 (Human), P21980-2, P21981 (Mouse), P51176 (Bovin), Q01841 (Chick)

Gene ID

7052 (TGM2), 21817 (Tgm2)

Available reactivities

Hu (Human), Ms (Mouse), Bov (Bovine), Chk (Chicken), Rt (Rat), Ze (Zebrafish), GP (Guinea Pig), Por (Porcine), Mky (Monkey), Can (Canine)

Available hosts

Mouse, Rabbit, Goat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Frozen Sections (C), ELISA (detection) (E(detection)), Immunoprecipitation (IP), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of Transglutaminase-2 (TGM2) antibody

Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. TGM2 acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, TGM2 is the autoantigen implicated in celiac disease.Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. Two transcript variants encoding different isoforms have been found for this gene.Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. Two transcript variants encoding different isoforms have been found for this gene.

General readings

Barone M.V. et al. Humoral Immune Response to Tissue Transglutaminase Is Related to Epithelial Cell Proliferation in Celiac Disease. Gastroenterology. April 2007,Volume 132, Issue 4, Pages 1245-1253 .

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Transglutaminase-2 (TGM2) (578-591) antibody

  Goat Polyclonal Antibody against Transglutaminase 2 (aa578-591)  
TA309513 (1µg/ml) staining of Mouse Kidney lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Bov, Hu, Ms, Por, Rt E, WB
0.1 mg / €360.00
  OriGene Technologies, Inc.

Transglutaminase-2 (TGM2) antibody

Human liver stained in immunohisto-chemistry with transgluaminase 2 antibody Rabbit Serum GP, Hu, Ms, Por, Rt C, E, WB
0.2 ml / €400.00
  OriGene Technologies GmbH

2 Item(s)

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