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Translin (TSN) antibody

Principal name

Translin (TSN) antibody

SwissProt ID

P79769 (Chick), Q08DM8 (Bovin), Q15631 (Human)

Gene ID

7247 (TSN)

Ncbi ID

9606, NP_004613, NP_004613.1, NM_004622

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of Translin (TSN) antibody

Translin, also designated testis brain RNA-binding protein (TB-RBP), is a single-stranded DNA- and RNA-binding protein that binds to the 3' UTR regions (Y and H elements) of stored mRNAs, which suppresses their in vitro translation. The human translin gene maps to chromosome 2q21.1 and encodes a 26 kDa protein that has been highly conserved throughout evolution. Translin forms a ring-shaped structure, which is responsible for DNA binding, and also contains a leucine zipper motif, which is thought to enable translin to form dimers. Translin exports specific mRNAs out of the nucleus, supported by its localization in both the nuclei and cytoplasm of neurons, and regulates their translation. Association with Trax (translin-associated factor X), inhibits the binding of translin to RNA, but enhances its binding to single stranded DNA sequences. Breakpoints in the TLS/FUS and CHOP loci contain consensus recognition motifs of translin, which associates with chromosomal translocations in liposarcomas.

TSN polyclonal antibody (A01), Lot # NIH49060222QCS1 Western Blot analysis of TSN expression in PC-12 ( Cat # L012V1 ).

H00007247-A01

Recombinant human TSN, 1- 228 aa

Immunohistochemistry analysis of Translin Antibody (Cat.-No AP20446PU-N) in paraffin-embedded human brain tissue.

AP20446PU-N

Western blot analysis of Translin Antibody (Cat.-No AP20446PU-N) in extracts from Jurkat cells.

AP20446PU-N

Immunohistochemistry analysis of paraffin-embedded human brain tissue, using TSN Antibody. The picture on the right is treated with the synthesized peptide.

Western blot analysis of extracts from Jurkat cells, using TSN Antibody. The lane on the right is treated with the synthesized peptide.

Formalin-Fixed, Paraffin-Embedded Human Testis stained with TSN Antibody Cat.-No AP32231PU-N

AP32231PU-N

Western blot analysis of extracts from Jurkat cells using TSN Antibody Cat.-No AP32231PU-N. The lane on the right is treated with the synthesized peptide.

AP32231PU-N

Immunohistochemical analysis of Translin staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.

Western blot analysis of Translin expression in MCF7 (A); HeLa (B); HepG2 (C) whole cell lysates.

Western blot analysis of extracts from Jurkat cells, using TSN antibody.The lane on the right is treated with the synthesized peptide.

TA314643

Immunohistochemistry analysis of paraffin-embedded human brain tissue using TSN antibody.The picture on the right is treated with the synthesized peptide.

TA314643

Western blot analysis of Translin in rat lung tissue lysate with Translin antibody at (A) 0.5 and (B) 1 ug/mL

TA319727

Immunohistochemistry of Translin in human lung tissue with Translin antibody at 5 ug/mL.

TA319727

Immunofluorescence of Translin in human lung tissue with Translin antibody at 20 ug/mL.

TA319727

TSN Antibody (Center) (Cat. #TA324488) western blot analysis in HL-60,Jurkat,K562 cell line mouse spleen tissue lysates (35ug/lane).This demonstrates the TSN antibody detected the TSN protein (arrow).

TA324488

TSN Antibody (Center) (Cat. #TA324488)immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of TSN Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.

TA324488

IF image of Hela cell stained with TSN Antibody(Center)(Cat#TA324488).Hela cells were incubated with TSN primary antibody (1:25, 1 h at 37?). For secondary antibody, Alexa Fluor® 488 conjugated donkey anti-rabbit antibody (green) was used (1:400).Cytoplasmic actin was counterstained with Alexa Fluor® 555 (red) conjugated Phalloidin (7 units/ml). Nuclei were counterstained with DAPI (blue) .TSN immunoreactivity is localized to Nucleus and Cytoplasm significantly.

TA324488

Primary Antibodies

Catalog No.	Host	Iso.	Pres.	React.	Applications
TA314643	Translin (TSN) antibody
	Rabbit polyclonal anti-TSN antibody
	Rabbit	IgG	Purified	Hu, Ms, Rt	E, P, WB	0.1 ml / €335.00
						OriGene Technologies, Inc.
+1 additional image
TA319727	Translin (TSN) (C-term) antibody
	Rabbit Polyclonal Translin Antibody
	Rabbit		Aff - Purified	Hu, Ms, Rt	E, ICC/IF, P, WB	0.1 mg / €415.00
						OriGene Technologies, Inc.
+2 additional images
TA324488	Translin (TSN) (Center) antibody
	Rabbit polyclonal TSN Antibody (Center)
	Rabbit	Ig	Aff - Purified	Hu	P, WB	0.4 ml / €415.00
						OriGene Technologies, Inc.
+2 additional images
AP20446PU-N	Translin (TSN) antibody
	Rabbit		Aff - Purified	Hu, Ms, Rt	P, WB	0.1 mg / €370.00
						OriGene Technologies GmbH
+1 additional image
AP32231PU-N	Translin (TSN) antibody
	Rabbit	IgG	Aff - Purified	Hu, Ms, Rt	E, P, WB	50 µl / €425.00
						OriGene Technologies GmbH
+1 additional image

Human Lenti ORF Particles

Catalog No.
RC201804L2V	Lenti ORF particles, TSN (mGFP-tagged) - Human translin (TSN), 200 uL, >10^7 TU/mL
		200 µl / €930.00
		OriGene Technologies, Inc.

RC201804L1V	Lenti ORF particles, TSN (Myc-DDK tagged) - Human translin (TSN) , 200 uL, >10^7 TU/mL
		200 µl / €830.00
		OriGene Technologies, Inc.

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