TREM1 antibody

Principal name

TREM1 antibody

Alternative names for TREM1 antibody

Triggering receptor expressed on myeloid cells 1, Triggering receptor expressed on monocytes 1

SwissProt ID

Q6QUN5 (Bovin), Q6TYI6 (Pig), Q9JKE2 (Mouse), Q9NP99 (Human)

Gene ID

54210 (TREM1), 58217 (Trem1)

Available reactivities

Hu (Human), Ms (Mouse)

Available hosts

Mouse, Rabbit, Rat, Sheep

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Frozen Sections (C), EPair for Elisa (EPair), Functional assay (FN), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P)

Background of TREM1 antibody

TREM-1 is a 30 kDa monomeric transmembrane activating receptor. TREM-1 is a member of the immunoglobulin superfamily. TREM-1 is expressed at low levels in the early development of the hematopoietic system in the promonoistic stage, and at high levels on the surface of immune cells, including neutrophils, monocytes and macrofages. TREM-1 is synthesized as a 234 amino acid (aa) precursor with a signal peptide (16 aa), an extracellular domain (184 aa), a transmembrane domain (29 aa), and a short cytoplasmic domain (5 aa). The short intracellular domain associates with a signal-transduction molecule, DNAX-activation protein 12 (DAP12), triggering the secretion of inflammatory cytokines that amplify the host response to microbial agents. TREM-1 acts in synergy with Toll-like receptor signaling pathways in amplifying the inflammatory response. Platelets express a natural ligand for TREM-1.
The expression of TREM-1 is greatly upregulated on phagocytic cells in the presence of bacteria and fungi. TREM-1 has a role in sepsis, inflammatory bowel disease (IBD) and multiple sclerosis. In contrast, TREM-1 is not upregulated in samples from patients with non-inefctious inflammatory conditions. During infections, receptor expression is modulated and soluble TREM-1 (sTREM-1, 17 kDa) is released. TREM-1 is shed from the membrane of activated phagocytes and can be found as sTREM-<1 in> body fluids like plasma and bronchoalveolar lavage fluid (BAL).
Elavated levels of sTREM-1 have a accuracy and sensitivity in detecting microbial infections as underlying disease. Furthermore, sTREM-1 has been associated with non-infectious inflammatory conditions like major abdominal surgery, peptic ulcer disease and COPD.

General readings

Kwofie,L.,et al. (2012) Sect Ann. Hematol. 91 (4), 605-611Wang,J.,et al. (2012) Mol Med Report 5 (3), 663-667

18 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

TREM1 antibody

  Rabbit Polyclonal TREM1 Antibody  
Western blot analysis of TREM1 in 293 cell lysate with TREM1 antibody at (A) 1 and (B) 2 ug/mL. Rabbit IgG Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

TREM1 antibody

TREM1 Mouse IgG1 6B1 Purified Hu E, FN, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

TREM1 antibody

TREM1 Rat IgG2a L5-B8 Purified Ms FN, ICC/IF, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

TREM1 antibody

TREM1 Rabbit Purified Hu C, E, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

TREM1 (Extracell. Dom.) antibody

TREM1 Rat IgG2 3C66 Purified Ms C, WB
0.1 mg / €440.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

Trem1 - mouse gene knockout kit via CRISPR

Trem1 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Trem1 - mouse gene knockout kit via CRISPR

Trem1 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Trem1 - mouse gene knockout kit via CRISPR

Trem1 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Trem1 - mouse gene knockout kit via CRISPR

Trem1 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

TREM1

  Recombinant protein of human triggering receptor expressed on myeloid cells 1 (TREM1)  
TREM1 Human > 95 %
Preparation: .
Purity Detail: >95% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
10 µg / €299.00
  OriGene Technologies, Inc.

TREM1 (21-205, His-tag)

TREM1 Human Purified > 85 % by SDS - PAGE E. coli
0.5 mg / €730.00
  Acris Antibodies GmbH

TREM1 (21-205, His-tag)

TREM1 Human Purified > 85 % by SDS - PAGE E. coli
0.1 mg / €300.00
  Acris Antibodies GmbH

ELISA Kits

Catalog No.    

Mouse TREM-1 ELISA Kit

Mouse TREM-1 ELISA Kit  
1 kit / €389.00
  OriGene Technologies, Inc.

OmniKine™ Human TREM-1 ELISA Kit

OmniKine™ Human TREM-1 ELISA Kit  
96 Tests / €440.00
  Assay Biotech

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, TREM1 (mGFP-tagged) - Human triggering receptor expressed on myeloid cells 1 (TREM1), 200 uL, >10^7 TU/mL

Lenti ORF particles, TREM1 (mGFP-tagged) - Human triggering receptor expressed on myeloid cells 1 (TREM1), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, TREM1 (Myc-DDK tagged) - Human triggering receptor expressed on myeloid cells 1 (TREM1) , 200 uL, >10^7 TU/mL

Lenti ORF particles, TREM1 (Myc-DDK tagged) - Human triggering receptor expressed on myeloid cells 1 (TREM1) , 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Trem1 (GFP-tagged) - Mouse triggering receptor expressed on myeloid cells 1 (Trem1), 200 uL, >10^7 TU/mL

Lenti ORF particles, Trem1 (GFP-tagged) - Mouse triggering receptor expressed on myeloid cells 1 (Trem1), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, Trem1 (Myc-DDK-tagged) - Mouse triggering receptor expressed on myeloid cells 1 (Trem1), 200 uL, >10^7 TU/mL

Lenti ORF particles, Trem1 (Myc-DDK-tagged) - Mouse triggering receptor expressed on myeloid cells 1 (Trem1), 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

18 Item(s)

per page
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