TREM1 antibody

Principal name

TREM1 antibody

Alternative names for TREM1 antibody

Triggering receptor expressed on myeloid cells 1, Triggering receptor expressed on monocytes 1

SwissProt ID

Q6QUN5 (Bovin), Q6TYI6 (Pig), Q9JKE2 (Mouse), Q9NP99 (Human)

Gene ID

54210 (TREM1), 58217 (Trem1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit, Rat, Sheep

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Flow Cytometry (F), Immunocytochemistry/Immunofluorescence (ICC/IF), ELISA (detection) (E(detection)), Frozen Sections (C), EPair for Elisa (EPair), Functional assay (FN), Paraffin Sections (P)

Background of TREM1 antibody

The monoclonal antibody L5-B8 recognizes human triggering receptor expressed on myeloid cells-1 (TREM-1). TREM-1 is a 30 kDa monomeric transmembrane activating receptor. TREM-1 is a member of the immunoglobulin superfamily. TREM-1 is expressed at low levels in the early development of the hematopoietic system in the promonoistic stage, and at high levels on the surface of immune cells, including neutrophils, monocytes and macrofages. TREM-1 is synthesized as a 234 amino acid (aa) precursor with a signal peptide (16 aa), an extracellular domain (184 aa), a transmembrane domain (29 aa), and a short cytoplasmic domain (5 aa). The short intracellular domain associates with a signal-transduction molecule, DNAX-activation protein 12 (DAP12), triggering the secretion of inflammatory cytokines that amplify the host response to microbial agents. TREM-1 acts in synergy with Toll-like receptor signaling pathways in amplifying the inflammatory response. Platelets express a natural ligand for TREM-1. The expression of TREM-1 is greatly upregulated on phagocytic cells in the presence of bacteria and fungi. TREM-1 has a role in sepsis, inflammatory bowel disease (IBD) and multiple sclerosis. In contrast, TREM-1 is not upregulated in samples from patients with non-inefctious inflammatory conditions. During infections, receptor expression is modulated and soluble TREM-1 (sTREM-1, 17 kDa) is released. TREM-1 is shed from the membrane of activated phagocytes and can be found as sTREM-1 in body fluids like plasma and bronchoalveolar lavage fluid (BAL). Elavated levels of sTREM-1 have a accuracy and sensitivity in detecting microbial infections as underlying disease. Furthermore, sTREM-1 has been associated with non-infectious inflammatory conditions like major abdominal surgery, peptic ulcer disease and COPD.

General readings

Kwofie,L.,et al. (2012) Sect Ann. Hematol. 91 (4), 605-611Wang,J.,et al. (2012) Mol Med Report 5 (3), 663-667

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

TREM1 antibody

Western blot analysis of TREM1 in 293 cell lysate with TREM1 antibody at (A) 1 and (B) 2 ug/mL. Rabbit IgG Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

TREM1 antibody

TREM1 Mouse IgG1 6B1 Purified Hu E, FN, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

TREM1 antibody

TREM1 Rat IgG2a L5-B8 Purified Ms FN, ICC/IF, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

TREM1 antibody

TREM1 Rabbit Purified Hu C, E, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

TREM1 (Extracell. Dom.) antibody

TREM1 Rat IgG2 3C66 Purified Ms C, WB
0.1 mg / €440.00
  Acris Antibodies GmbH

TREM1 antibody

Western Blot analysis of TREM1 expression in transfected 293T cell line (H00054210-T01) by TREM1 MaxPab polyclonal antibody.

Lane 1: TREM1 transfected lysate(25.74 KDa).
Lane 2: Non-transfected lysate. Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

TREM1 antibody

TREM1 MaxPab rabbit polyclonal antibody. Western Blot analysis of TREM1 expression in mouse kidney. Rabbit Purified Hu, Ms E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

TREM1 antibody

Detection limit for recombinant GST tagged TREM1 is approximately 0.1ng/ml as a capture antibody. Mouse IgG2b 3F5 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

TREM1 antibody

TREM1 monoclonal antibody (M04), clone 2E2 Western Blot analysis of TREM1 expression in HL-60 ( Cat # L014V1 ). Mouse IgG2a 2E2 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

TREM1 antibody

TREM1 Sheep Hu E
1 ml / €560.00
  Abnova Taiwan Corp.

TREM1 antibody

TREM1 Rabbit IgG Aff - Purified Ms C, P, WB
0.1 mg / €290.00
  Boster Immunoleader

TREM1 antibody

Recombinant human TREM-1 Fc protein (20 ng per lane) was resolved by electrophoresis, transferred to nitrocellulose, and probed monoclonal antibody against TREM-1 (clone TREM-26). Proteins were visualized using a goat anti-mouse secondary conjugated to HRP and a chemiluminescence detection system. Mouse IgG1 TREM-26 Aff - Purified Hu F, WB
0.1 mg / €400.00
  Novus Biologicals Inc.

TREM1 antibody

ELISA: TREM1 Antibody (TREM-26) [Biotin] [NB100-77954] serial dilutions of recombinant protein from 2000 to 8 pg/ml are recommended for each ELISA plate. The reagent be titrated for optimal performance for each application. Mouse IgG1 TREM-26 Biotin Hu E, F
0.1 mg / €360.00
  Novus Biologicals Inc.

TREM1 antibody

flow cytometry / FACS analysis: TREM1 Antibody (TREM-37) [NB100-77977] Mouse IgG2b TREM-37 Aff - Purified Hu E, F, WB
0.1 mg / €400.00
  Novus Biologicals Inc.

TREM1 antibody

TREM1 Rat IgG2a L5-B8.2A12.3A12 Ms C, F, FN, ICC/IF, WB
0.25 mg / €400.00
  Novus Biologicals Inc.

TREM1 antibody

TREM1 Rat IgG2a L5-B8 Aff - Purified Ms F, FN, ICC/IF, WB
0.1 mg / €580.00
  Novus Biologicals Inc.

TREM1 antibody

TREM1 Rat IgG2a L5-B8 Aff - Purified Ms F, FN, ICC/IF, WB
50 µg / €360.00
  Novus Biologicals Inc.

TREM1 antibody

Immunohistochemistry-Paraffin: TREM1 Antibody [NBP1-80664] Immunohistochemical staining of human urinary bladder shows strong cytoplasmic positivity in urothelial cells. Rabbit IgG Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

TREM1

TREM1 Human > 95 %
Preparation: .
Purity Detail: >95% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
10 µg / €299.00
  OriGene Technologies, Inc.

TREM1 (21-205, His-tag)

TREM1 Human Purified > 85 % by SDS - PAGE E. coli
0.5 mg / €730.00
  Acris Antibodies GmbH

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