TREM2 antibody

Principal name

TREM2 antibody

Alternative names for TREM2 antibody

TREM-2, Trem2a, Trem2b, Trem2c, Triggering receptor expressed on myeloid cells 2, Triggering receptor expressed on monocytes 2

SwissProt ID

Q99NH8 (Mouse), Q9NZC2 (Human)

Gene ID

54209 (TREM2), 83433 (Trem2)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Eq (Equine)

Available hosts

Goat, Mouse, Rat, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunoprecipitation (IP), Frozen Sections (C), Flow Cytometry (F)

Background of TREM2 antibody

TREM-2 is a 26 kDa transmembrane glycoprotein that consists of a single extracellular immunoglobulin-like domain, a transmembrane region with a charged lysine residue and a short cytoplasmic tail. It associates with DNAX-activation protein 12 (DAP12) for signaling and function. TREM-2 is expressed on immature monocyte-derived dendritic cells. After activation by microbial products or tumor necrosis factor (TNF) and TNF-related proteins, dendritic cells downregulate the expression of TREM-2. TREM-2 is also expressed by osteoclasts and microglia, where it is involved in bone modeling and brain function, respectively. Another role of TREM-2 might be promoting the removal of apoptotic cells, organic matrix and macromolecules by microglia. Defects in TREM-2 are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also called presenile dementia with bone cysts or Nasu-Hakola disease (NHD). TREM-2, like TREM-1, can be cleaved on the membrane to release a soluble form of TREM-2 (sTREM-2). Elevated levels of sTREM-2 in CSF of multiple sclerosis patients have been detected. This elevated level may inhibit the anti-inflammatory function of the membrane-bound receptor suggesting sTREM-2 to be a possible target for future therapies.

General readings

Takahashi K, Prinz M, Stagi M, Chechneva O, Neumann H. TREM2-transduced myeloid precursors mediate nervous tissue debris clearance and facilitate recovery in an animal model of multiple sclerosis. PLoS Med. 2007 Apr;4(4):e124. PMID: 17425404

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

TREM2 antibody

Sstaining of Mouse Liver lysate using Anti-TREM2 Antibody Cat.-No AP23686PU-N at 0.3 µg/ml (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Ms, Rt E, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

TREM2 (C-term) antibody

TA305737 (2.5ug/ml) staining of paraffin embedded Human Spleen. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. Goat Aff - Purified Hu P
0.1 mg / €325.00
  OriGene Technologies, Inc.

TREM2 antibody

WB Suggested Anti-TREM2 Antibody Titration: 0.2-1 ug/ml; Positive Control: Human Muscle Rabbit IgG Purified Bov, Eq, Hu, Ms, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

TREM2 antibody

Western blot analysis: Cell lysates of HeLa, MCF7, LNCaP and mouse brain (30 ug) were resolved by SDS-PAGE, transferred to NC membrane and probed with anti-human TREM2 (1/500). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. Mouse IgG3 2B5 Purified Hu, Ms E, WB
0.1 ml / €310.00
  Acris Antibodies GmbH

TREM2 antibody

Western blot analysis: Cell lysates of HeLa, MCF7, LNCaP and mouse brain (30 ug) were resolved by SDS-PAGE, transferred to NC membrane and probed with anti-human TREM2 (1/500). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. Mouse IgG3 2B5 Purified Hu, Ms E, WB
50 µl / €230.00
  Acris Antibodies GmbH

TREM2 antibody

TREM2 Rat IgG2b 6E9 Purified Ms E, IP
0.1 mg / €340.00
  Acris Antibodies GmbH

TREM2 (C-term) antibody

Spleen, macrophages: Formalin-Fixed Paraffin-Embedded (FFPE) Goat IgG Aff - Purified Hu E, P
50 µg / €470.00
  Acris Antibodies GmbH

TREM2 antibody

Cell lysates of HeLa ( lane 1 ), MCF-7 ( lane 2 ), LNCaP ( lane 3 ) and mouse brain ( lane 4 ) ( 30 µg ) were resolved by SDS-PAGE and probed with TREM2 monoclonal antibody, clone 2B5 ( Cat # MAB2056 ) ( 1:500 ). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. Mouse IgG3 2B5 Hu, Ms E, WB
0.1 ml / €390.00
  Abnova Taiwan Corp.

TREM2 antibody

TREM2 Goat Hu E
0.1 mg / €400.00
  Abnova Taiwan Corp.

TREM2 (Center) antibody

Human Muscle; WB Suggested Anti-TREM2 Antibody Titration: 0.2-1 ug/ml. Positive Control: Human Muscle; TREM2 antibody - middle region (ARP49413_P050) in Human Muscle cells using Western Blot Rabbit Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

TREM2 antibody

TREM2 Mouse IgG3 2B5 Purified Hu, Ms E, WB
0.1 ml / €380.00
  Novus Biologicals Inc.

TREM2 antibody

TREM2 Goat Aff - Purified Ms E, WB
0.1 mg / €400.00
  Novus Biologicals Inc.

TREM2 antibody

Immunohistochemistry-Paraffin: TREM2 Antibody [NBP1-80662] - Immunohistochemical staining of human bone marrow shows strong cytoplasmic positivity in bone marrow poietic cells. Rabbit IgG Aff - Purified Hu P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

TREM2 antibody

Immunohistochemistry-Paraffin: TREM2 Antibody [NBP1-80663] Immunohistochemical staining of human testis shows strong cytoplasmic positivity in cells of seminiferus ducts. Rabbit IgG Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

TREM2b (Extracell. Dom.) antibody

TREM2b Rat IgG2 5J46 Purified Ms WB
0.1 mg / €440.00
  Acris Antibodies GmbH

TREM2b antibody

TREM2b Rat IgG2 RM0139-5J46 Purified Ms WB
0.1 mg / €450.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

TREM2 (19-161, His-tag)

TREM2 Human Purified > 90 % by SDS - PAGE E. coli
0.25 mg / €730.00
  Acris Antibodies GmbH

TREM2 (19-161, His-tag)

TREM2 Human Purified > 90 % by SDS - PAGE E. coli
50 µg / €300.00
  Acris Antibodies GmbH

TREM2

TREM2 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

TREM2

TREM2 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

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