TRHR antibody

Principal name

TRHR antibody

Alternative names for TRHR antibody

TRH-R, Thyrotropin-releasing hormone receptor, Thyroliberin receptor

SwissProt ID

O46639 (Bovin), O93603 (Chick), P21761 (Mouse), P34981 (Human), Q01717 (Rat), Q28596 (Sheep)

Gene ID

7201 (TRHR), 25570 (Trhr)

Available reactivities

Fi (Fish), Hst (Hamster), Hu (Human), Ms (Mouse), Op (Opossum), Rt (Rat), Tr (Turkey), Bov (Bovine), Can (Canine), Chk (Chicken), Eq (Equine), Por (Porcine), Rb (Rabbit), Sh (Sheep), Xen (Xenopus), Bear, African clawed frog, L (Lizard), Chimp (Chimpanzee), Mky (Monkey)

Available hosts

Rabbit, Mouse

Available applications

Paraffin Sections (P), Frozen Sections (C), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Enzyme Immunoassay (E)

Background of TRHR antibody

Thyrotropin-releasing hormone (TRH), is a widely distributed tripeptide which acts as a hormone, a paracrine regulatory factor and a neurotransmitter/neuromodulator; it is expressed in many parts of the brain as well as in various peripheral tissues. In the hypothalamus, TRH is secreted from the paraventricular nucleus (VPN) by TRH neurons prior to a post-translatiol processing from its precursor, pro-TRH. A key player in the regulation of the hypothalamus-pituitary-thyroid (HPT) axis, TRH is released into the hypophyseal portal circulation of the median eminence and reaches the pituitary, where it binds to TRH receptors, thereby stimulates the secretion of tyrothropin (thyroid-stimulating hormone; TSH). TSH, in turn, affects the thyroid to produce T4 which is subsequently converted into its biologically-active alog, T3 - a negative mediator of TRH. In the tanycytes, ependymal cells of glial origin located in close proximity to the VPN, T4 is converted to T3 by the enzyme deiodise II (dio2) - a counterpart to deiodise III (dio3) which conversely ictivates the above mentioned thyroid hormones, thus so indirectly promotes the production of TRHs. TRH receptor 1 (TRH-R1), the only identified TRH receptor in humans, is a G protein-coupled receptor (GPCR) abundant in the anterior pituitary, neuroendocrine system, autonomic nervous system and the visceral regions of the brain. Like all members of GPCRs, TRH receptor has seven transmembrane domains, and extracellular N-terminus and an intracellular C-termil tail. TRH receptor couples Gq upon activation which in turn leads to the activation of phospholipase C. From a behavioral aspect, it was shown that TRH-coupled TRH-R1 increases cognitive arousal by directly exciting the sleep/wake system in the lateral hypothalamic area, and inhibits seizure activity in the hippocampus by facilitating GABA release, whereas its deficiency, as observed in mutant model mice, is linked to growth retardation, depression, and anxiety-like behavior.

General readings

Iwasaki, T., et al., (1996). J. Biol. Chem. 271 (36), 22183-22188.

16 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

TRHR antibody

Western blot analysis of extracts from COS-7 cells, using TRHR antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TRHR antibody

Western blot analysis of rat brain (lanes 1 and 4), Jurkat cells (lanes 2 and 5) and MS1cells (lanes 3 and 6) lysates: 1-3. Anti-Thyrotropin-Releasing Hormone Receptor 1 antibody, (1:200). 4-6. Anti-Thyrotropin-Releasing Hormone Receptor 1 antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

TRHR (C-term) antibody

Anti-TRH Receptor / TRHR antibody IHC of human Lung, Non-Small Cell Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Fi, Hst, Hu, Ms, Op, Rt, Tr P
50 µg / €379.00
  OriGene Technologies, Inc.

TRHR (3rd cytoplasm. dom.) antibody

Figure 1. Immunohistochemical staining of brain (neurons and glia) using anti-TRHR antibody SP4630P. Rabbit Aff - Purified Bear, Bov, Can, Chk, Elephant, Eq, Hu, Ms, Platypus, Por, Rb, Rt, Sh, Tr, Xen P
50 µg / €379.00
  OriGene Technologies, Inc.

TRHR (C-term) antibody

Immunohistochemical staining of Brain (Neurons and Glia) using anti- TRHR antibody SP4631P Rabbit Aff - Purified Bear, Bov, Can, Elephant, Eq, Hst, Hu, Ms, Op, Rb, Rt, Sh P
50 µg / €379.00
  OriGene Technologies, Inc.

TRHR (C-term) antibody

Immunohistochemical staining of formalin.fixed, paraffin-embedded human brain (neuron) after heat-induced antigen retrieval using anti-TRHR antibody cat. no. AP06817PU-N Rabbit Aff - Purified Can, Chk, Elephant, Eq, Fi, Hu, L, Op, Por, Rb, Sh, Tr, Xen P
50 µg / €379.00
  OriGene Technologies, Inc.

TRHR antibody

Western blot analysis on COS7 cell lysate using TRHR Antibody Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

TRHR (350-400) antibody

Thyroid: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit IgG Aff - Purified Bov, Can, Hu, Mky, Ms, Op, Rt P, WB
50 µg / €470.00
  Acris Antibodies GmbH

TRHR antibody

TRHR Mouse Hu WB
0.5 mg / €1,400.00
  Abnova Taiwan Corp.

TRHR antibody

IHC analysis of human thyroid using TRHR polyclonal antibody ( Cat # PB0315 ) at 10 µg/ml. Rabbit Chimp, Hu, Mky C, WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

TRHR antibody

Immunofluorescence analysis of A549 cells, using TRHR Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, WB
50 µg / €205.00
  Assay Biotech

TRHR antibody

Immunofluorescence analysis of A549 cells, using TRHR Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, WB
0.1 mg / €310.00
  Assay Biotech

TRHR antibody

TRHR Rabbit Aff - Purified African clawed frog, Bov, Can, Chk, Hu, Ms, Por, Rt
0.1 mg / €310.00
  AVIVA Systems Biology

TRHR antibody

Adrenal Rabbit Hu P
50 µl / €440.00
  Novus Biologicals Inc.

TRHR1 antibody

Western blot (WB) analysis of TRH-R1 antibody (Cat.-No.: AP01441PU-N) in extracts from COS7 cells. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

Lysates (Overexpressed)

Catalog No.    

TRHR overexpression lysate

TRHR overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

16 Item(s)

per page
  • LinkedIn