Triadin (TRDN) antibody

Principal name

Triadin (TRDN) antibody

SwissProt ID

P82179 (Canfa), Q13061 (Human), Q28820 (Rabit)

Gene ID

100009519 (TRDN), 10345

Available reactivities

Ms (Mouse), Rb (Rabbit), Rt (Rat), Hu (Human)

Available hosts

Mouse, Rabbit

Available applications

Frozen Sections (C), Enzyme Immunoassay (E), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P)

Background of Triadin (TRDN) antibody

The junction between the transverse tubules (T-tubules) and the sarcoplasmic reticulum (SR) of skeletal muscle is called the triad. At the triad, dihydropyridine receptors (DHPR's) of the T-tubule serve as voltage sensors in excitation-contraction coupling, while ryanodine receptors (RyR's), the calcium release channels, exist in the membrane of the terminal cisternae of the SR. It is thought that during slow phase depolarization of the T-tubule, a third protein, triadin (MW 95 kDa) transmits electrochemical signals to the SR through direct interaction with both DHPR's and RyR's.
Though its exact role in this signaling process is unclear, triadin has been shown to co-localize with both DHPR and RYR at the junctional face of the terminal cisternae.

General readings

This product has been used in:Caswell AH et al. Localization and partial characterization of the oligomeric disulfide-linked molecular weight 95,000 protein (triadin) which binds the ryanodine and dihydropyridine receptors in skeletal muscle triadic vesicles. Biochemistry 30:7507-13 (1991). PubMed PMID: 1649631
General / background references:Protasi F et al. Role of ryanodine receptors in the assembly of calcium release units in skeletal muscle. J Cell Biol 140:831-42 (1998). PubMed PMID: 9472035
Motoike HK et al. Extraction of junctional complexes from triad junctions of rabbit skeletal muscle. J Muscle Res Cell Motil 15:493-504 (1994). PubMed PMID: 7860698
Flucher BE et al. Triad formation: organization and function of the sarcoplasmic reticulum calcium release channel and triadin in normal and dysgenic muscle in vitro. J Cell Biol 123:1161-74 (1993). PubMed PMID: 8245124
Brandt NR et al. Detection and localization of triadin in rat ventricular muscle. J Membr Biol 131:219-28 (1993). PubMed PMID: 7684084
Brandt NR et al. Effects of anti-triadin antibody on Ca2+ release from sarcoplasmic reticulum. FEBS Lett 299:57-9 (1992). PubMed PMID: 1544475

5 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Triadin (TRDN) antibody

Triadin (TRDN) Mouse IgG1 IIG12 Ascites Ms, Rb ICC/IF, WB
0.1 ml / €400.00
  Novus Biologicals Inc.

Triadin (TRDN) antibody

Figure 1 shows immunolocalization of triadin in mouse breast muscle using NB300-623. Mouse IgG GE 4.90 Ascites Ms, Rb, Rt C, E, IP, P, WB
0.1 ml / €400.00
  Novus Biologicals Inc.

Triadin (TRDN) antibody

Immunohistochemistry-Paraffin: Triadin Antibody [NBP1-87417] - Immunohistochemical staining of human skeletal muscle shows strong cytoplasmic positivity in myocytes. Rabbit IgG Aff - Purified Hu P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Triadin (TRDN)

Triadin (TRDN) Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

Triadin (TRDN)

Triadin (TRDN) Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

5 Item(s)

per page
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