TRIB3 antibody

Principal name

TRIB3 antibody

Alternative names for TRIB3 antibody

Tribbles homolog 3, TRB3, TRB-3, NIPK, SKIP3

SwissProt ID

Q0VCE3 (Bovin), Q8K4K2 (Mouse), Q96RU7 (Human), Q9WTQ6 (Rat)

Gene ID

57761 (TRIB3)

Available reactivities

Hu (Human), Can (Canine), Mky (Monkey), Ms (Mouse), Rt (Rat), Bov (Bovine), Por (Porcine), Rb (Rabbit), GP (Guinea Pig)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), EPair for Elisa (EPair), Immunoprecipitation (IP), Frozen Sections (C)

Background of TRIB3 antibody

A novel inhibitor of cell division, Tribbles, blocks mitosis at a critical point in Drosophila morphogenesis. Recently, mammalian homologuesof Tribbles (Trbs) have been identified that control mitogen activated protein kinase (MAPK) activity. TRIB3 is a putative protein kinase that is induced by the transcription factor NFkappaB. TRIB3 is a negative regulator of NFkappaB and can also sensitize cells to TNF and TRAIL induced apoptosis. In addition, this protein can negatively regulate the cell survival serine threonine kinase AKT1.TRIB 3 disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. May bind directly to and mask the Thr-308 phosphorylation site in AKT1. Binds to ATF4 and inhibits its transcriptional activation activity. Interacts with MAPK kinases and regulates activation of MAP kinases. May play a role in programmed neuronal cell death but does not appear to affect non neuronal cells. Does not display kinase activity.TRIB3 interacts with AKT1, AKT2, ATF4, MAP2K1 and MAP2K7.Its highest expression in liver, pancreas, peripheral blood leukocytes and bone marrow. Also highly expressed in a number of primary lung, colon and breast tumors. TRIB3 is induced by hypoxia. It contains 1 protein kinase domain.

General readings

Du K. et al. (2003) Science. 300:1574-1577.Hegedus Z. et al. (2006) Cell Mol Life Sci. 63:1632-1641.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

TRIB3 antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-TRIB3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min, TA807483) Mouse IgG1 OTI3C6 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

TRIB3 antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human pancreas tissue using anti-TRIB3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min, TA807612) Mouse IgG1 OTI3F3 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

TRIB3 antibody

Anti-TRIB3 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit IgG Purified Bov, Can, Hu, Mky, Por, Rb
50 µg / €345.00
  OriGene Technologies, Inc.

TRIB3 antibody

Anti-TRIB3 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit IgG Purified Hu, Mky P
50 µg / €345.00
  OriGene Technologies, Inc.

TRIB3 antibody

WB Suggested Anti-TRIB3 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:62500; Positive Control: ACHN cell lysate Rabbit IgG Purified Bov, Can, GP, Hu, Por, Rb WB
50 µg / €325.00
  OriGene Technologies, Inc.

TRIB3 antibody

Host: Rabbit; Target Name: TRIB3; Sample Tissue: Fetal Kidney lysates; Antibody Dilution: 1.0 ug/ml Rabbit IgG Purified Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

TRIB3 antibody

Western blot analysis of TRB3 in mouse kidney tissue lysate with TRB3 antibody at (A) 1 and (B) 2 ug/mL. Rabbit IgG Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

TRIB3 antibody

Immunohistochemical staining of paraffin-embedded Human Kidney tissue within the normal limits using anti-TRIB3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min, TA807482) Mouse IgG1 OTI3F6 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

TRIB3 antibody

Immunohistochemical staining of paraffin-embedded Human lymph node tissue within the normal limits using anti-TRIB3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min, TA807484) Mouse IgG1 OTI1F6 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

TRIB3 antibody

Immunohistochemical staining of paraffin-embedded Human lymph node tissue within the normal limits using anti-TRIB3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120°C for 3 min, TA807540)(1:150) Mouse IgG1 OTI2D11 Purified Hu P
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

TRIB3 antibody

Immunohistochemical staining of paraffin-embedded Human Kidney tissue within the normal limits using anti-TRIB3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min, TA807611) Mouse IgG1 OTI3G4 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

TRIB3 (N-term) antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. Rabbit Ig Purified Hu P, WB

Regular Price: 0.4 ml / €370.00

Special Price: 0.4 ml / €231.00

  Acris Antibodies GmbH

TRIB3 (C-term) antibody

The anti-NPK Pab is used in Western blot to detect NPK in mouse skeletal muscle tissue lysate. Rabbit Ig Purified Hu, Ms WB
0.4 ml / €370.00
  Acris Antibodies GmbH

TRIB3 antibody

TRIB3 Rabbit Purified Hu, Ms, Rt C, E, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

TRIB3 antibody

Western Blot analysis of TRIB3 expression in transfected 293T cell line (H00057761-T01) by TRIB3 MaxPab polyclonal antibody.

Lane 1: TRIB3 transfected lysate(39.38 KDa).
Lane 2: Non-transfected lysate. Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

TRIB3 antibody

Western Blot analysis of TRIB3 expression in transfected 293T cell line (H00057761-T02) by TRIB3 MaxPab polyclonal antibody.

Lane 1: TRIB3 transfected lysate(39.60 KDa).
Lane 2: Non-transfected lysate. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

TRIB3 antibody

Immunofluorescence of monoclonal antibody to TRIB3 on A-431 cell. [antibody concentration 10 ug/ml] Mouse IgG1 1H2 Purified Hu E, ICC/IF, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

TRIB3 antibody

TRIB3 monoclonal antibody (M05), clone 2F7 Western Blot analysis of TRIB3 expression in HepG2 ( Cat # L019V1 ). Mouse IgG1 2F7 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

TRIB3 antibody

Immunofluorescence of monoclonal antibody to TRIB3 on HeLa cell. [antibody concentration 10 ug/ml] Mouse IgG1 2G5 Purified Hu E, ICC/IF, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

TRIB3 antibody

TRIB3 Mouse IgG1 3D7 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

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