TRIM13 / RNF77 antibody

Principal name

TRIM13 / RNF77 antibody

Alternative names for TRIM13 / RNF77 antibody

RFP2, LEU5, RING finger protein 77, Tripartite motif-containing protein 13, Putative tumor suppressor RFP2, Leukemia-associated protein 5, B-cell chronic lymphocytic leukemia tumor suppressor Leu5

SwissProt ID

O60858 (Human), Q9CYB0 (Mouse)

Gene ID

10206 (TRIM13), 66597 (Trim13)

Available reactivities

Bov (Bovine), Hu (Human), Ms (Mouse), Rt (Rat), Can (Canine)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E)

Background of TRIM13 / RNF77 antibody

TRIM13 is an E3 ubiquitin ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from the ER through a set of processes named ER-associated degradation (ERAD). This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins. TRIM13 enhances ionizing radiation-induced p53/TP53 stability and apoptosis via ubiquitinating MDM2 and AKT1 and decreasing AKT1 kinase activity through MDM2 and AKT1 proteasomal degradation, regulates ER stress-induced autophagy, and may act as a tumor suppressor.

General readings

"The RBCC gene RFP2 (Leu5) encodes a novel transmembrane E3 ubiquitin ligase involved in ERAD." Lerner M., Corcoran M., Cepeda D., Nielsen M.L., Zubarev R., Ponten F., Uhlen M., Hober S., Grander D., Sangfelt O. Mol. Biol. Cell 18:1670-1682(2007)
"Ret finger protein 2 enhances ionizing radiation-induced apoptosis via degradation of AKT and MDM2." Joo H.M., Kim J.Y., Jeong J.B., Seong K.M., Nam S.Y., Yang K.H., Kim C.S., Kim H.S., Jeong M., An S., Jin Y.W. Eur. J. Cell Biol. 90:420-431(2011)
"TRIM13 regulates ER stress induced autophagy and clonogenic ability of the cells." Tomar D., Singh R., Singh A.K., Pandya C.D., Singh R. Biochim. Biophys. Acta 1823:316-326(2012)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

TRIM13 / RNF77 antibody

  Rabbit Polyclonal Anti-RFP2 Antibody  
WB Suggested Anti-RFP2 Antibody Titration: 0.125 ug/ml; ELISA Titer: 1:62500; Positive Control: Human Lung Rabbit Aff - Purified Bov, Hu, Ms, Rt P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

TRIM13 / RNF77 (transcript variant 3)

  Recombinant protein of human tripartite motif-containing 13 (TRIM13), transcript variant 3  
TRIM13 / RNF77 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Trim13 (GFP-tagged) - Mouse tripartite motif-containing 13 (Trim13), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, Trim13 (GFP-tagged) - Mouse tripartite motif-containing 13 (Trim13), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, Trim13 (GFP-tagged) - Mouse tripartite motif-containing 13 (Trim13), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, Trim13 (GFP-tagged) - Mouse tripartite motif-containing 13 (Trim13), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, Trim13 (Myc-DDK-tagged) - Mouse tripartite motif-containing 13 (Trim13), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, Trim13 (Myc-DDK-tagged) - Mouse tripartite motif-containing 13 (Trim13), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

Lenti ORF particles, Trim13 (Myc-DDK-tagged) - Mouse tripartite motif-containing 13 (Trim13), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, Trim13 (Myc-DDK-tagged) - Mouse tripartite motif-containing 13 (Trim13), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

6 Item(s)

per page
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