TRIM13 / RNF77 antibody

Principal name

TRIM13 / RNF77 antibody

Alternative names for TRIM13 / RNF77 antibody

RFP2, LEU5, RING finger protein 77, Tripartite motif-containing protein 13, Putative tumor suppressor RFP2, Leukemia-associated protein 5, B-cell chronic lymphocytic leukemia tumor suppressor Leu5

SwissProt ID

O60858 (Human), Q9CYB0 (Mouse)

Gene ID

10206 (TRIM13)

Available reactivities

Bov (Bovine), Hu (Human), Ms (Mouse), Rt (Rat), Can (Canine)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E)

Background of TRIM13 / RNF77 antibody

TRIM13 is an E3 ubiquitin ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from the ER through a set of processes named ER-associated degradation (ERAD). This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins. TRIM13 enhances ionizing radiation-induced p53/TP53 stability and apoptosis via ubiquitinating MDM2 and AKT1 and decreasing AKT1 kinase activity through MDM2 and AKT1 proteasomal degradation, regulates ER stress-induced autophagy, and may act as a tumor suppressor.

General readings

"The RBCC gene RFP2 (Leu5) encodes a novel transmembrane E3 ubiquitin ligase involved in ERAD." Lerner M., Corcoran M., Cepeda D., Nielsen M.L., Zubarev R., Ponten F., Uhlen M., Hober S., Grander D., Sangfelt O. Mol. Biol. Cell 18:1670-1682(2007)
"Ret finger protein 2 enhances ionizing radiation-induced apoptosis via degradation of AKT and MDM2." Joo H.M., Kim J.Y., Jeong J.B., Seong K.M., Nam S.Y., Yang K.H., Kim C.S., Kim H.S., Jeong M., An S., Jin Y.W. Eur. J. Cell Biol. 90:420-431(2011)
"TRIM13 regulates ER stress induced autophagy and clonogenic ability of the cells." Tomar D., Singh R., Singh A.K., Pandya C.D., Singh R. Biochim. Biophys. Acta 1823:316-326(2012)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

TRIM13 / RNF77 antibody

WB Suggested Anti-RFP2 Antibody Titration: 0.125 ug/ml; ELISA Titer: 1:62500; Positive Control: Human Lung Rabbit Aff - Purified Bov, Hu, Ms, Rt P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

TRIM13 / RNF77 antibody

Human Lung; . Rabbit Anti-TRIM13 Antibody. . Catalog Number:. ARP34143 . Paraffin Embedded Tissue: Human alveolar cell . Cellular Data: Epithelial cells of renal tubule. Antibody Concentration: 4.0-8.0 ug/ml. Magnification: 400X Rabbit Aff - Purified Bov, Hu, Ms, Rt P, WB
50 µg / €350.00
  AVIVA Systems Biology

TRIM13 / RNF77 antibody

RFP2 polyclonal antibody (A01), Lot # UYL6060127QCS1 Western Blot analysis of RFP2 expression in HeLa ( Cat # L013V1 ). Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

TRIM13 / RNF77 antibody

Detection limit for recombinant GST tagged RFP2 is approximately 0.1ng/ml as a capture antibody. Mouse IgG2a 2A11 Purified Hu E
0.1 mg / €370.00
  Abnova Taiwan Corp.

TRIM13 / RNF77 antibody

TRIM13 / RNF77 Mouse IgG1 1E5 Purified Hu E
0.1 mg / €370.00
  Abnova Taiwan Corp.

TRIM13 / RNF77 antibody

Human Jurkat; WB Suggested Anti-RFP2 Antibody Titration: 2.5ug/ml. Positive Control: Jurkat cell lysate. TRIM13 is supported by BioGPS gene expression data to be expressed in Jurkat.; RFP2 antibody - middle region (ARP34144_T100) in Human Jurkat cells using Western Blot Rabbit Aff - Purified Bov, Can, Hu, Ms, Rt WB
0.1 mg / €310.00
  AVIVA Systems Biology

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

TRIM13 / RNF77 (transcript variant 3)

TRIM13 / RNF77 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

TRIM13 / RNF77

TRIM13 / RNF77 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

TRIM13 / RNF77

TRIM13 / RNF77 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

TRIM13 / RNF77

TRIM13 / RNF77 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

TRIM13 / RNF77

TRIM13 / RNF77 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

11 Item(s)

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