Tristetraproline (TTP) antibody

Principal name

Tristetraproline (TTP) antibody

Alternative names for Tristetraproline (TTP) antibody

ZFP36, Zfp-36, G0S24, RNF162A, TIS11A, TIS11, TTP, Zinc finger protein 36 homolog, Growth factor-inducible nuclear protein NUP475, G0/G1 switch regulatory protein 24

SwissProt ID

P22893 (Mouse), P26651 (Human), P47973 (Rat), P53781 (Bovin), Q6S9E0 (Sheep)

Gene ID

7538 (ZFP36)

Available reactivities

Bov (Bovine), Can (Canine), Chk (Chicken), Hu (Human), Ms (Mouse), Por (Porcine), Rt (Rat), Ze (Zebrafish), African clawed frog, Mky (Monkey)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Frozen Sections (C), Flow Cytometry (F)

Background of Tristetraproline (TTP) antibody

TTP (Tristetraprolin, Nup 475, TIS11, G0S24, or ZFP36) is a member of the CCCH tandem zinc finger protein family. It is a nuclear RNA-binding protein that functions as a trans-acting factor. It is involved in post-transcriptional regulation of cytokine genes, most notably Tumor Necrosis Factor alpha (TNF-α). Upon activation by lipopolysaccharides, TTP binds TNF-α mRNA at AU-rich domains in the 3'-untranslated Region (3'-UTR) and induces deadenylation, thereby destabilizing the mRNA and tagging it for degradation. To produce this effect, TTP recruits other trans-acting factors to its C-terminal domain and mRNA-decay enzymes to its N-terminal domain. TTP is deactivated by phosphorylation driven by mitogen-activated protein kinase-activated protein kinase 2 (MK2) and p53. Therefore, TTP/MK2 regulates the biosynthesis of TNF-α and mediates inflammatory responses involving TNF-α. Knockout of TTP in mice produces arthritis, alopecia, dermatitis, among a range of other phenotypes related to overexpression of TNF-α.

General readings

"MK2-induced tristetraprolin:14-3-3 complexes prevent stress granule association and ARE-mRNA decay." Stoecklin G., Stubbs T., Kedersha N., Wax S., Rigby W.F., Blackwell T.K., Anderson P. EMBO J. 23:1313-1324(2004)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Tristetraproline (TTP) antibody

Immunohistochemical staining of paraffin-embedded Human endometrium tissue within the normal limits using anti-ZFP36 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA502383) Mouse IgG2a OTI1A2 Purified Hu F, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Tristetraproline (TTP) antibody

Immunohistochemical staining of paraffin-embedded Human endometrium tissue within the normal limits using anti-ZFP36 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500626) Mouse IgG1 OTI8B5 Purified Hu F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Tristetraproline (TTP) antibody

Anti-ZFP36 mouse monoclonal antibody (TA502376) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY ZFP36(RC202049). Mouse IgG1 OTI1H6 Purified Hu F, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Tristetraproline (TTP) antibody

Western blot analysis of extracts (35ug) from 9 different cell lines by using anti-ZFP36 monoclonal antibody. Mouse IgG1 OTI4B10 Purified Hu F, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

Tristetraproline (TTP) antibody

Anti-ZFP36 mouse monoclonal antibody (TA502385) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY ZFP36(RC202049). Mouse IgG1 OTI4E1 Purified Hu F, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Tristetraproline (TTP) antibody

Anti-ZFP36 mouse monoclonal antibody (TA500621) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY ZFP36(RC202049). Mouse IgG1 OTI3D10 Purified Hu F, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Tristetraproline (TTP) antibody

Tristetraproline (TTP) Mouse IgG1 OTI1G9 Purified Can, Hu, Mky F, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Tristetraproline (TTP) antibody

Anti-ZFP36 mouse monoclonal antibody (TA502379) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY ZFP36(RC202049). Mouse IgG1 OTI3C3 Purified Hu F, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Tristetraproline (TTP) antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY ZFP36 (RC202049, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-ZFP36. Mouse IgG1 OTI3H1 Purified Hu F, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Tristetraproline (TTP) antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY ZFP36 (RC202049, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-ZFP36. Mouse IgG1 OTI5E3 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Tristetraproline (TTP) antibody

Anti-ZFP36 mouse monoclonal antibody (TA502382) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY ZFP36(RC202049). Mouse IgG1 OTI1F2 Purified Hu F, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Tristetraproline (TTP) antibody

Anti-ZFP36 mouse monoclonal antibody (TA502384) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY ZFP36(RC202049). Mouse IgG2a OTI1C8 Purified Hu F, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Tristetraproline (TTP) antibody

Human HepG2; WB Suggested Anti-ZFP36 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:62500. Positive Control: HepG2 cell lysate; ZFP36 antibody - N-terminal region (AP42287PU-N) in Human HepG2 cells using Western Blot Rabbit Aff - Purified African clawed frog, Bov, Can, Chk, Hu, Ms, Por, Rt, Ze WB
50 µg / €350.00
  Acris Antibodies GmbH

Tristetraproline (TTP) antibody

Tristetraproline (TTP) Rabbit Purified Hu C, E, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

Tristetraproline (TTP) antibody

Western Blot analysis of ZFP36 expression in transfected 293T cell line (H00007538-T02) by ZFP36 MaxPab polyclonal antibody.

Lane 1: ZFP36 transfected lysate(34.00 KDa).
Lane 2: Non-transfected lysate. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

Tristetraproline (TTP) antibody

Human Liver; WB Suggested Anti-HSZFP36 Antibody Titration: 0.2-1 ug/ml. Positive Control: Human Liver; HSZFP36 antibody - middle region (ARP32899_P050) in Human Liver cells using Western Blot Rabbit IgG Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

Tristetraproline (TTP) antibody

Human HepG2; WB Suggested Anti-ZFP36 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:62500. Positive Control: HepG2 cell lysate; ZFP36 antibody - N-terminal region (ARP34385_P050) in Human HepG2 cells using Western Blot Rabbit Aff - Purified African clawed frog, Bov, Can, Chk, Hu, Ms, Por, Rt, Ze WB
50 µg / €350.00
  AVIVA Systems Biology

Tristetraproline (TTP) antibody

Human Thymus; Thymus; ZFP36 antibody - N-terminal region (ARP34386_P050) in Human Thymus cells using Immunohistochemistry Rabbit Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

Tristetraproline (TTP) antibody

Human Lung; WB Suggested Anti-ZFP36 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:312500. Positive Control: Human Lung; ZFP36 antibody - N-terminal region (ARP38303_P050) in Human Lung cells using Western Blot Rabbit Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

Tristetraproline (TTP) antibody

Human Small intestine; . IHC Information: Paraffin embedded small intestine, submucosal plexus tissue, tested with an antibody Dilution of 5 ug/ml.; ZFP36 antibody - middle region (ARP38304_P050) in Human Small intestine cells using Immunohistochemistry Rabbit Aff - Purified Bov, Can, Hu, Ms, Por, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

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