TrkA antibody

Principal name

TrkA antibody

Alternative names for TrkA antibody

NTRK1, TRK, Trk-A, High affinity nerve growth factor receptor, Neurotrophic tyrosine kinase receptor type 1, TRK1-transforming tyrosine kinase protein, p140-TrkA

SwissProt ID

P04629 (Human), P35739 (Rat), Q3UFB7 (Mouse)

Gene ID

4914 (NTRK1), 59109 (Ntrk1), 18211

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit, Goat, Mouse

Available applications

Immunoprecipitation (IP), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Frozen Sections (C), Enzyme Immunoassay (E), Flow Cytometry (F)

Background of TrkA antibody

The tropomyosin-related kinase (Trk) family consists of TrkA, TrkB and TrkC. These receptors each bind to and are activated by one or more of the neurotrophins, which include neural growth factor (NGF), brain derived neurotrophic factor (BDNF) and neurotrophic factors 3 and 4/5 (NT-3, NT-4/5). TrkA is the high-affinity receptor for NGF but also binds NT3 with lower affinity. TrkA is primarily expressed in neuronal cells, while an alternatively spliced isoform is expressed in non-neuronal cells. The TrkA receptor along with the p75 NTR and NGF regulate the growth, development, survival and repair of the vertebrate nervous system. Specifically, during development TrkA is involved in processes controlling axon and neurite growth, the regulation of dendrite architecture, patterning of neuronal innervation and modulation of proteins important for neuronal function such as neurotransmitters. In the adult nervous system TrkA is involved in regulating synaptic function and plasticity, neuron survival as well as mediating pain and inflammation. TrkA is a heavily glycosylated transmembrane protein and contains 13 potential N-linked glycosylation sites. This is a HCX protein. HCX Expression System Details HCX proteins mimic the proteins in the human body because they are expressed from human, rather than animal, insect or bacterial cells. This process gives them human post-translational modifications. Recombinant DNA techniques allow a human protein with the correct amino acid sequence to be expressed in a non-human cell line. However, non-human cells lack the appropriate cellular machinery, such as specific glycosyltransferases, necessary to produce the correct human post-translational modifications of a protein. An extreme example is seen in E. coli cells, which produce recombinant proteins with no glycosylation, as the above figure illustrates. Rodent and yeast cells are able to glycosylate proteins, but they are still different from glycosylation in human cells. Expression System Resultant Proteins Human (e.g. K562, HEK293) Correct amino acid sequence Human post-translational modifications Rodent (e.g. CHO, NSO) Correct amino acid sequence Some natural glycosylation - not human-like Yeast (e.g. Pichia) Correct amino acid sequence Some natural glycosylation - not human-like E.Coli Correct amino acid sequence No PTMs Although there have been significant attempts to make non-human cell derived cytokines more human-like, there is a growing awareness that in many instances, particularly in therapeutics, cytokines should mimic those found in the body as closely as possible.

General readings

Huang EJ & Reichardt LF (2003) Annu Rev Biochem. 72: 609-42.

  1. Quick-Filters:
  2. Highly Validated (1)
  3. Overnight Delivery (1)

Items 1 to 20 of 71 total

per page
Page:
  1. 1
  2. 2
  3. 3
  4. 4

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

TrkA antibody

Western blot analysis of rat (lanes 1 and 3) and mouse (lanes 2 and 4) brain lysates: 1, 2. Anti-TrkA (extracellular) antibody , (1:200). 3, 4. Anti-TrkA (extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

TrkA antibody

Predicted cell location: Cytoplasm. Positive control: Human colon and ovarian cancer tissue . Recommended dilution: 1/100-300  The image on the left is immunohistochemistry of paraffin-embedded human colon cancer tissue using NTRK1 antibody at dilution 1/90, on the right is treated with the synthetic peptide. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrkA antibody

Predicted cell location: Cytoplasm. Positive control: Human colon and lung cancer tissue . Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded human colon cancer tissue using NTRK1 antibody at dilution 1/30, on the right is treated with the synthetic peptide. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrkA antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human pancreas tissue using anti-NTRK1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min, TA806413) Mouse IgG1 OTI5B6 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

TrkA antibody

Confocal Immunofluorescence analysis of PC-12 cells using TrkA antibody Cat.-No AM06329SU-N (green), showing membrane and cytoplasmic localization. Blue: DRAQ5 fluorescent DNA dye. Mouse IgG1 6B2 Ascites Hu ICC/IF, WB
0.1 ml / €400.00
  Acris Antibodies GmbH

TrkA antibody

Western blot analysis of TrkA expression using Jurkat (Lane 1) and 3T3 (Lane 2) cell lysates. Rabbit Purified Hu, Ms, Rt IP, P, WB
0.1 mg / €370.00
  Acris Antibodies GmbH

TrkA pTyr490 antibody

TrkA Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, IP, P, WB
0.1 mg / €480.00
  Acris Antibodies GmbH

TrkA antibody

Immunohistochemistry (IHC) analyzes of Trk A antibody (Cat.-No.: AP06418PU-N) in paraffin-embedded human brain tissue. Rabbit Aff - Purified Hu ICC/IF, P
0.1 mg / €350.00
  Acris Antibodies GmbH

TrkA antibody

Immunohistochemistry analysis of TrkA Antibody (Cat.-No. AP06589PU-N) in paraffin-embedded Human brain tissue. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

TrkA antibody

AP08798PU-N at 2.5 µg/ml, staining TrkA in Adrenal tissue by Immunohistochemistry (Formalin-Fixed Paraffin-Embedded). Rabbit IgG Aff - Purified Hu, Ms, Rt IP, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

TrkA pSer791 antibody

Figure 1. Immunofluorescence staining of methanol-fixed HeLa cells using TrkA pSer791 Antibody (#AP09480PU, Red). Rabbit Aff - Purified Hu ICC/IF
0.1 ml / €320.00
  Acris Antibodies GmbH

TrkA pSer791 antibody

Figure 1. Immunofluorescence staining of methanol-fixed HeLa cells using TrkA pSer791 Antibody (#AP09480PU, Red). Rabbit Aff - Purified Hu ICC/IF
50 µl / €240.00
  Acris Antibodies GmbH

TrkA antibody

Immunofluorescence staining of methanol-fixed HeLa cells using TrkA Antibody Rabbit Aff - Purified Hu ICC/IF
0.1 ml / €270.00
  Acris Antibodies GmbH

TrkA antibody

Immunofluorescence staining of methanol-fixed HeLa cells using TrkA Antibody Rabbit Aff - Purified Hu ICC/IF
50 µl / €230.00
  Acris Antibodies GmbH

TrkA pTyr791 antibody

Dot blot analysis of anti-Phospho-TrkA-Y791 Pab (Cat.#AP12733PU-N) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5ug per ml. Rabbit Ig Aff - Purified Hu WB

Regular Price: 0.4 ml / €370.00

Special Price: 0.4 ml / €231.00

  Acris Antibodies GmbH

TrkA (Center) antibody

Western blot analysis of anti-TRKA Antibody (Center) Pab in mouse liver tissue lysates (35ug/lane). TRKA(arrow) was detected using the purified polyclonal antibody. Rabbit Ig Purified Hu, Ms WB
0.4 ml / €370.00
  Acris Antibodies GmbH

TrkA antibody

Western blot analysis of hTrkA-pY791 (AP18228PU-N) in HepG2 cell line lysates (35ug/lane). TRK (arrow) was detected using the purified Pab. Rabbit Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

TrkA antibody

TrkA Rabbit IgG Aff - Purified Hu, Ms, Rt WB
0.1 mg / €340.00
  Acris Antibodies GmbH

TrkA pTyr791 antibody

Immunohistochemical analysis of paraffin-embedded human brain tissue, using Trk A (phospho-Tyr791) antibody AP55689PU-N (left)or the same antibody preincubated with blocking peptide (right). Rabbit Aff - Purified Hu P
0.1 ml / €340.00
  Acris Antibodies GmbH

TrkA pTyr791 antibody

Immunohistochemical analysis of paraffin-embedded human brain tissue, using Trk A (phospho-Tyr791) antibody AP55689PU-N (left)or the same antibody preincubated with blocking peptide (right). Rabbit Aff - Purified Hu P
50 µl / €270.00
  Acris Antibodies GmbH

Items 1 to 20 of 71 total

per page
Page:
  1. 1
  2. 2
  3. 3
  4. 4
  • LinkedIn