TrkB antibody

Principal name

TrkB antibody

Alternative names for TrkB antibody

TRKB, NTRK2, BDNF/NT-3 growth factors receptor, Neurotrophic tyrosine kinase receptor type 2, TrkB tyrosine kinase, GP145-TrkB

SwissProt ID

P15209 (Mouse), Q16620 (Human), Q63604 (Rat)

Gene ID

4915 (NTRK2), 18212 (Ntrk2), 25054

Available reactivities

Chk (Chicken), Hu (Human), Ms (Mouse), Rt (Rat), Mky (Monkey), Can (Canine), Bov (Bovine), Rb (Rabbit)

Available hosts

Rabbit, Goat, Mouse, Rat, Sheep

Available applications

Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Frozen Sections (C), Enzyme Immunoassay (E), Immunoprecipitation (IP), Paraffin Sections (P), Flow Cytometry (F), ELISA (detection) (E(detection)), EPair for Elisa (EPair)

Background of TrkB antibody

BDNF and NT-4 belong to the neurotrophin family which also includes NGF and NT-3. These neurotrophins bind two groups of receptors. The p75NTR receptor is common to all four neurotrophins and is a member of the tumor necrosis factor receptor family. The tropomyosin-related kise (Trk) receptors are receptor tyrosine kises (RTKs) and three receptors form this family: TrkA, TrkB, and TrkC.As mentioned above, the p75NTR receptor binds to all neurotrophins with similar affinities while the Trk receptors are the ones to display the selectivity for the neurotrophins. TrkA is activated by NGF binding, TrkB by that of BDNF and NT-4, while TrkC is stimulated by the binding of NT-3.All three Trk receptors are highly expressed in the mammalian brain in very distinct regions and are also expressed in the peripheral nervous system.Cholinergic neurons in the basal forebrain exclusively express TrkA, while TrkB and TrkC are highly expressed in the hippocampus. Motor and sensory neurons in the peripheral nervous system express Trk receptors. Interestingly, Trk receptors are not essential for development, but knockout mice die shortly after birth. Indeed, TrkB-deficient mice demonstrate a significant decrease in motor neurons and syptogenesis.Trk receptors have many motifs in the extracellular region, including cell-adhesion domains, three tandem leucine rich motifs flanked by two clusters of cysteines. In the membrane proximal region of the receptor there are also two immunoglobulin-like domains. The binding of neurotrophins to Trk receptors promotes receptor dimerization resulting in kise activation. Activated Trk receptors then phosphorylate a cascade of sigling molecules including the Ras/ERK, PI3K/Akt pathways and PLC-g1. Activated Trk receptors also create interl docking sites for other sigling adaptor proteins to bind to. Splice variants of TrkA, TrkB and TrkC have been observed. These splice isoforms are mainly affected in the tyrosine kise domain of the receptor lying in the cytoplasm. Endocytosis is an important sigling trait of Trk receptors.Following neurotrophin binding to the Trk receptor, the receptor complex is then interlized via endocytosis in order to termite sigling. However, in the axol compartment of neurons the interlization process of the neurotrophin complexed to the receptor is part of the sigling process and is important for activating transcription processes in the nucleus.

General readings

Heldt SA et al., (2014) J. Neurosci., 34:(7)2444-2450.Xiang J et al., (2014) J. Clin. Invest., 124:(1)85-98.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

TrkB antibody

Immunohistochemical staining of paraffin-embedded Human lung tissue within the normal limits using anti-NTRK2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500386) Mouse IgG1 OTI2E1 Purified Hu ICC/IF, P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

TrkB antibody

Immunohistochemistry-Paraffin: TrkB Antibody (2E1) [NBP1-47898] - Immunohistochemical staining of paraffin-embedded lung tissue using anti-NTRK2mouse monoclonal antibody. (Dilution 1:50) Mouse 2E1 Aff - Purified Hu, Mky ICC/IF, P, WB
0.1 ml / €620.00
  Novus Biologicals Inc.

TrkB antibody

Western blot of rat synaptic membrane preparation showing specific immunolabeling of the ~ 93k TrkB protein. Rabbit IgG Purified Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrkB antibody

Western blot analysis of Trk B expression in HepG2 whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt P
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrkB antibody

Western blot analysis of Trk B expression in NIH-3T3 whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrkB antibody

TA326730 (0.05µg/ml) staining of Human Hippocampus (A), Cerebral Cortex (B) and Cerebellum (C) lysates (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Can, Hu, Ms, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

TrkB antibody

Western blot analysis of rat brain membranes (lanes 1 and 3) and HEK-TrkB transfected cell lysates (lanes 2 and 4): 1, 2. Anti-TrkB (extracellular) antibody , (1:200). 3, 4. Anti-TrkB (extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

TrkB antibody

Anti-NTRK2 / TRKB antibody IHC of human brain, neurons. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Purified Hu
50 µg / €379.00
  OriGene Technologies, Inc.

TrkB Control Peptide

TrkB Purified
50 µg / €190.00
  Acris Antibodies GmbH

TrkB antibody

Western Blot Analysis of trkB expression in HL-60 Cell Lysate. Rabbit Aff - Purified Chk, Hu, Ms, Rt ICC/IF, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

TrkB pTyr705 antibody

Immunohistochemistry (IHC) analyzes of Trk-B pTyr705 antibody (Cat.-No.: AP01712PU-N) in paraffin-embedded human brain tissue. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

TrkB antibody

Immunohistochemistry (IHC) analyzes of Trk B antibody (Cat.-No.: AP06419PU-N) in paraffin-embedded human brain tissue. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

TrkB pTyr705 antibody

Western blot analysis of extracts from Mouse brain tissue, using TrkB (Phospho-Tyr705) Antibody AP08028PU and the same antibody preincubated with blocking peptide. Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 ml / €320.00
  Acris Antibodies GmbH

TrkB pTyr705 antibody

Western blot analysis of extracts from Mouse brain tissue, using TrkB (Phospho-Tyr705) Antibody AP08028PU and the same antibody preincubated with blocking peptide. Rabbit Aff - Purified Hu, Ms, Rt WB
50 µl / €240.00
  Acris Antibodies GmbH

TrkB (1-429) antibody

Immunohistochemistry: AP08871PU-N TrkB antibody staining of Formalin-Fixed Paraffin-Embedded of Human Brain, Cortex at 10 µg/ml followed by biotinylated Goat anti-Rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Rabbit IgG Aff - Purified Hu, Ms, Rt P, WB
50 µg / €470.00
  Acris Antibodies GmbH

TrkB pTyr515 antibody

Figure 1. Immunofluorescence staining of methanol-fixed HeLa cells using TRkB pTyr515 Antibody (#AP09481PU, Red). Rabbit Aff - Purified Hu, Rt ICC/IF
0.1 ml / €320.00
  Acris Antibodies GmbH

TrkB pTyr515 antibody

Figure 1. Immunofluorescence staining of methanol-fixed HeLa cells using TRkB pTyr515 Antibody (#AP09481PU, Red). Rabbit Aff - Purified Hu, Rt ICC/IF
50 µl / €240.00
  Acris Antibodies GmbH

TrkB antibody

Immunohistochemistry (IHC) analyzes of Trk B antibody (Cat.-No.: AP20762PU-N) in paraffin-embedded human brain tissue. Rabbit Aff - Purified Hu, Ms, Rt P
0.1 mg / €350.00
  Acris Antibodies GmbH

TrkB (703-707) antibody

Western blot analysis of extract from C6 cell and using TrkB Antibody AP26046PU-N. Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 ml / €270.00
  Acris Antibodies GmbH

TrkB (703-707) antibody

Western blot analysis of extract from C6 cell and using TrkB Antibody AP26046PU-N. Rabbit Aff - Purified Hu, Ms, Rt WB
50 µl / €230.00
  Acris Antibodies GmbH

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