TrkC antibody

Principal name

TrkC antibody

Alternative names for TrkC antibody

NTRK3, NT-3 growth factor receptor, Neurotrophic tyrosine kinase receptor type 3, TrkC tyrosine kinase, GP145-TrkC

SwissProt ID

Q03351 (Rat), Q16288 (Human), Q16288-3, Q6VNS1 (Mouse)

Gene ID

4916 (NTRK3), 18213 (Ntrk3), 29613

Available reactivities

Hu (Human), Rt (Rat), Ms (Mouse), Por (Porcine), Bov (Bovine), Chk (Chicken), Ze (Zebrafish), African clawed frog, Can (Canine), Mky (Monkey), Eq (Equine), GP (Guinea Pig), Rb (Rabbit)

Available hosts

Mouse, Rabbit, Goat, Sheep, Rat

Available applications

ELISA (detection) (E(detection)), Western blot / Immunoblot (WB), Frozen Sections (C), Enzyme Immunoassay (E), Paraffin Sections (P), Immunoprecipitation (IP), Immunocytochemistry/Immunofluorescence (ICC/IF), Flow Cytometry (F)

Background of TrkC antibody

BDNF and NT-4 belong to the neurotrophin family which also includes NGF and NT-3. These neurotrophins bind two groups of receptors. The p75NTR receptor is common to all four neurotrophins and is a member of the tumor necrosis factor receptor family. The tropomyosin-related kise (Trk) receptors are receptor tyrosine kises (RTKs) and three receptors form this family: TrkA, TrkB, and TrkC.As mentioned above, the p75NTR receptor binds to all neurotrophins with similar affinities while the Trk receptors are the ones to display the selectivity for the neurotrophins. TrkA is activated by NGF binding, TrkB by that of BDNF and NT-4, while TrkC is stimulated by the binding of NT-3.All three Trk receptors are highly expressed in the mammalian brain in very distinct regions and are also expressed in the peripheral nervous system. Cholinergic neurons in the basal forebrain exclusively express TrkA, while TrkB and TrkC are highly expressed in the hippocampus. Motor and sensory neurons in the peripheral nervous system express Trk receptors. Interestingly, Trk receptors are not essential for development, but knockout mice die shortly after birth. Indeed, TrkB-deficient mice demonstrate a significant decrease in motor neurons and syptogenesis.rk receptors have many motifs in the extracellular region, including cell-adhesion domains, three tandem leucine rich motifs flanked by two clusters of cysteines. In the membrane proximal region of the receptor there are also two immunoglobulin-like domains. The binding of neurotrophins to Trk receptors promotes receptor dimerization resulting in kise activation. Activated Trk receptors then phosphorylate a cascade of sigling molecules including the Ras/ERK, PI3K/Akt pathways and PLC-?1. Activated Trk receptors also create interl docking sites for other sigling adaptor proteins to bind to.Splice variants of TrkA, TrkB and TrkC have been observed. These splice isoforms are mainly affected in the tyrosine kise domain of the receptor lying in the cytoplasm. Endocytosis is an important sigling trait of Trk receptors.Following neurotrophin binding to the Trk receptor, the receptor complex is then interlized via endocytosis in order to termite sigling. However, in the axol compartment of neurons the interlization process of the neurotrophin complexed to the receptor is part of the sigling process and is important for activating transcription processes in the nucleus.

  1. Quick-Filters:
  2. Highly Validated (8)

Items 1 to 20 of 48 total

per page
Page:
  1. 1
  2. 2
  3. 3

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

TrkC antibody

WB Suggested Anti-NTRK3 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 312500; Positive Control: Human Liver Rabbit IgG Purified Bov, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

TrkC antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-NTRK3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500536) Mouse IgG1 OTI24B3 Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

TrkC antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human pancreas tissue using anti-NTRK3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500537) Mouse IgG1 OTI2B8 Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

TrkC antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of thyroid tissue using anti-NTRK3mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500538, Dilution 1:50) Mouse IgG1 OTI4E10 Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

TrkC antibody

Human 293T; Host:Rabbit. Target Name:NTRK3. Sample Tissue:Human 293T. Antibody Dilution: 1.0ug/ml.; NTRK3 antibody - C-terminal region (ARP51318_P050) in Human 293T cells using Western Blot Rabbit Aff - Purified African clawed frog, Bov, Chk, Hu, Ms, Por, Rt, Ze WB
50 µg / €350.00
  AVIVA Systems Biology

TrkC antibody

Immunofluorescence: TrkC Antibody [NB100-98827] - Rat trigeminal ganglia DAPI stained. Sheep Serum Ms, Rt C, P, WB
0.1 ml / €400.00
  Novus Biologicals Inc.

TrkC antibody

Immunohistochemistry: TrkC Antibody [NB100-98829] - IHC on rat spinal cord (paraffin section) using Rabbit antibody to extracellular domain of TrkC (Trk-C, NTRK3, NT-3 growth factor receptor): whole serum at 1 : 200 dilution incubated overnight at 4C, developed with DAB/No and counterstained with hematoxylin. Rabbit Serum Hu, Ms, Por, Rt ICC/IF, P
0.1 ml / €400.00
  Novus Biologicals Inc.

TrkC antibody

Immunohistochemistry-Paraffin: TrkC Antibody (2B8) [NBP1-47900] - Immunohistochemical staining of paraffin-embedded Carcinoma of pancreas tissue using anti-NTRK3mouse monoclonal antibody. (Dilution 1:50) Mouse IgG1 2B8 Aff - Purified Hu ICC/IF, P, WB
0.1 ml / €530.00
  Novus Biologicals Inc.

TrkC antibody

TrkC Antibody (Cat. #TA324970) western blot analysis in U87-MG cell line lysates (35ug/lane).This demonstrates the TrkC antibody detected the TrkC protein (arrow). Rabbit IgG Purified Hu WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

TrkC antibody

Western blot analysis of HEK-TrkC transfected cells (lanes 1 and 3) and HEK untransfected cells (lanes 2 and 4) lysates: 1-2. Anti-TrkC (extracellular) antibody , (1:400). 3-4. Anti-TrkC (extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

TrkC antibody

Western blot analysis of extracts of various cell lines, using NTRK3 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

TrkC antibody

Immunocytochemistry/Immunofluorescence: TrkC Antibody [TA336908] - TrkC antibody was tested in mouse brain using DAB with hematoxylin counterstain. Rabbit Purified Hu, Ms C, ICC/IF, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrkC antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY NTRK3 (RC203781, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-NTRK3. Mouse IgG1 OTI19B8 Purified Can, Hu, Rt WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

TrkC antibody

Immunohistochemical analysis of paraffin-embedded human lymph node using NTRK3 mouse mAb with DAB staining. Mouse IgG1 7H6 Ascites ELISA, Hu P, WB
0.1 ml / €440.00
  Acris Antibodies GmbH

TrkC antibody

Western blot analysis using NTRK3 mouse mAb against extracellular domain of human NTRK3 (aa32-429). Mouse IgG1 4G5 Ascites Hu WB
0.1 ml / €400.00
  Acris Antibodies GmbH

TrkC (1-429) antibody

Adrenal medulla: Formalin-Fixed Paraffin-Embedded (FFPE) Goat IgG Aff - Purified Hu, Ms, Rt P, WB
50 µg / €470.00
  Acris Antibodies GmbH

TrkC (N-term) antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Rabbit Ig Purified Hu P
0.4 ml / €370.00
  Acris Antibodies GmbH

TrkC antibody

Western Blot analysis of NTRK3 expression in transfected 293T cell line (H00004916-T01) by NTRK3 MaxPab polyclonal antibody.

Lane 1: NTRK3 transfected lysate(67.32 KDa).
Lane 2: Non-transfected lysate. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

TrkC antibody

TrkC Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

TrkC antibody

Western Blot analysis of NTRK3 expression in transfected 293T cell line (H00004916-T01) by NTRK3 MaxPab polyclonal antibody.

Lane 1: NTRK3 transfected lysate(68.50 KDa).
Lane 2: Non-transfected lysate. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

Items 1 to 20 of 48 total

per page
Page:
  1. 1
  2. 2
  3. 3
  • LinkedIn