TrkC antibody

Principal name

TrkC antibody

Alternative names for TrkC antibody

NTRK3, NT-3 growth factor receptor, Neurotrophic tyrosine kinase receptor type 3, TrkC tyrosine kinase, GP145-TrkC

SwissProt ID

Q03351 (Rat), Q16288 (Human), Q16288-3, Q6VNS1 (Mouse)

Gene ID

4916 (NTRK3), 18213 (Ntrk3), 29613

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Chk (Chicken), Por (Porcine), Ze (Zebrafish), African clawed frog, Mky (Monkey), Can (Canine), Eq (Equine), GP (Guinea Pig), Rb (Rabbit)

Available hosts

Rabbit, Goat, Mouse

Available applications

Enzyme Immunoassay (E), Paraffin Sections (P), Western blot / Immunoblot (WB), Flow Cytometry (F), ELISA (detection) (E(detection)), Frozen Sections (C), Immunoprecipitation (IP), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of TrkC antibody

BDNF and NT-4 belong to the neurotrophin family which also includes NGF and NT-3. These neurotrophins bind two groups of receptors. The p75NTR receptor is common to all four neurotrophins and is a member of the tumor necrosis factor receptor family. The tropomyosin-related kise (Trk) receptors are receptor tyrosine kises (RTKs) and three receptors form this family: TrkA, TrkB, and TrkC.As mentioned above, the p75NTR receptor binds to all neurotrophins with similar affinities while the Trk receptors are the ones to display the selectivity for the neurotrophins. TrkA is activated by NGF binding, TrkB by that of BDNF and NT-4, while TrkC is stimulated by the binding of NT-3.All three Trk receptors are highly expressed in the mammalian brain in very distinct regions and are also expressed in the peripheral nervous system. Cholinergic neurons in the basal forebrain exclusively express TrkA, while TrkB and TrkC are highly expressed in the hippocampus. Motor and sensory neurons in the peripheral nervous system express Trk receptors. Interestingly, Trk receptors are not essential for development, but knockout mice die shortly after birth. Indeed, TrkB-deficient mice demonstrate a significant decrease in motor neurons and syptogenesis.rk receptors have many motifs in the extracellular region, including cell-adhesion domains, three tandem leucine rich motifs flanked by two clusters of cysteines. In the membrane proximal region of the receptor there are also two immunoglobulin-like domains. The binding of neurotrophins to Trk receptors promotes receptor dimerization resulting in kise activation. Activated Trk receptors then phosphorylate a cascade of sigling molecules including the Ras/ERK, PI3K/Akt pathways and PLC-?1. Activated Trk receptors also create interl docking sites for other sigling adaptor proteins to bind to.Splice variants of TrkA, TrkB and TrkC have been observed. These splice isoforms are mainly affected in the tyrosine kise domain of the receptor lying in the cytoplasm. Endocytosis is an important sigling trait of Trk receptors.Following neurotrophin binding to the Trk receptor, the receptor complex is then interlized via endocytosis in order to termite sigling. However, in the axol compartment of neurons the interlization process of the neurotrophin complexed to the receptor is part of the sigling process and is important for activating transcription processes in the nucleus.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

TrkC antibody

  Rabbit Polyclonal Anti-NTRK3  
WB Suggested Anti-NTRK3 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 312500; Positive Control: Human Liver Rabbit IgG Purified Bov, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

TrkC antibody

  anti-NTRK3 (TrkC) mouse monoclonal antibody, clone OTI24B3 (formerly 24B3)  
Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-NTRK3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500536) Mouse IgG1 OTI24B3 Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

TrkC antibody

  anti-NTRK3 (TrkC) mouse monoclonal antibody, clone OTI2B8 (formerly 2B8)  
Immunohistochemical staining of paraffin-embedded Carcinoma of Human pancreas tissue using anti-NTRK3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500537) Mouse IgG1 OTI2B8 Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

TrkC antibody

  anti-NTRK3 (TrkC) mouse monoclonal antibody, clone OTI4E10 (formerly 4E10)  
Immunohistochemical staining of paraffin-embedded Carcinoma of thyroid tissue using anti-NTRK3mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500538, Dilution 1:50) Mouse IgG1 OTI4E10 Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

TrkC antibody

  Rabbit polyclonal TrkC Antibody  
TrkC Antibody (Cat. #TA324970) western blot analysis in U87-MG cell line lysates (35ug/lane).This demonstrates the TrkC antibody detected the TrkC protein (arrow). Rabbit IgG Purified Hu WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

TrkC antibody

  Rabbit polyclonal Anti-TrkC (extracellular)  
Western blot analysis of HEK-TrkC transfected cells (lanes 1 and 3) and HEK untransfected cells (lanes 2 and 4) lysates: 1-2. Anti-TrkC (extracellular) antibody , (1:400). 3-4. Anti-TrkC (extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt C, ICC/IF, WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

TrkC antibody

  Rabbit anti-NTRK3 Polyclonal Antibody  
Western blot analysis of extracts of various cell lines, using NTRK3 antibody. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

TrkC antibody

  Rabbit Polyclonal TrkC Antibody  
Immunocytochemistry/Immunofluorescence: TrkC Antibody [TA336908] - TrkC antibody was tested in mouse brain using DAB with hematoxylin counterstain. Rabbit Purified Hu, Ms C, ICC/IF, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrkC antibody

  anti-NTRK3 (TrkC) mouse monoclonal antibody, clone OTI19B8 (formerly 19B8)  
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY NTRK3 (RC203781, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-NTRK3. Mouse IgG1 OTI19B8 Purified Can, Hu, Rt WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

TrkC antibody

Immunohistochemical analysis of paraffin-embedded human lymph node using NTRK3 mouse mAb with DAB staining. Mouse IgG1 7H6 Ascites ELISA, Hu P, WB
0.1 ml / €440.00
  Acris Antibodies GmbH

TrkC antibody

Western blot analysis using NTRK3 mouse mAb against extracellular domain of human NTRK3 (aa32-429). Mouse IgG1 4G5 Ascites Hu WB
0.1 ml / €400.00
  Acris Antibodies GmbH

TrkC (1-429) antibody

Adrenal medulla: Formalin-Fixed Paraffin-Embedded (FFPE) Goat IgG Aff - Purified Hu, Ms, Rt P, WB
50 µg / €470.00
  Acris Antibodies GmbH

TrkC (N-term) antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Rabbit Ig Purified Hu P
0.4 ml / €370.00
  Acris Antibodies GmbH

TrkC pTyr516 antibody

Immunohistochemistry analysis of paraffin-embedded human brain, using Trk C (Phospho-Tyr516) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
50 µg / €230.00
  Assay Biotech

TrkC pTyr516 antibody

Immunohistochemistry analysis of paraffin-embedded human brain, using Trk C (Phospho-Tyr516) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €330.00
  Assay Biotech

TrkC antibody

TrkC Mouse IgG PE Hu, Rt F
1 ml / €440.00
  Neuromics Antibodies

TrkC antibody

TrkC Mouse IgG2b 75219 Purified Hu, Rt C, E, WB
0.5 mg / €410.00
  Neuromics Antibodies

CRISPR

Catalog No. Species Donor Vector  

NTRK3 - human gene knockout kit via CRISPR

NTRK3 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

NTRK3 - human gene knockout kit via CRISPR

NTRK3 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

NTRK3 - human gene knockout kit via CRISPR

NTRK3 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Items 1 to 20 of 38 total

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