Tropomyosin-1 (TPM1) antibody

Principal name

Tropomyosin-1 (TPM1) antibody

Alternative names for Tropomyosin-1 (TPM1) antibody

Tropomyosin alpha-1 chain, Alpha-tropomyosin, TMSA, C15orf13

SwissProt ID

P04268 (Chick), P09493 (Human), P42639 (Pig), P58771 (Mouse), P58772 (Rabit), Q5KR49 (Bovin)

Gene ID

7168 (TPM1), 396366, 22003 (Tpm1)

Available reactivities

Can (Canine), Hu (Human), Ms (Mouse), Rt (Rat), Ze (Zebrafish), African clawed frog, Chk (Chicken), Rb (Rabbit), Bov (Bovine), Por (Porcine), Eq (Equine), GP (Guinea Pig), Sh (Sheep)

Available hosts

Rabbit, Mouse, Sheep

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Enzyme Immunoassay (E)

Background of Tropomyosin-1 (TPM1) antibody

TPM1 is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction.This gene is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The encoded protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction. In smooth muscle and non-muscle cells, alternatively spliced transcript variants encoding a range of isoforms have been described. Mutations in this gene are associated with type 3 familial hypertrophic cardiomyopathy.

General readings

Lin,J.C. (2005) Mol. Cell. Biol. 25 (22), 10111-10121

3 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Tropomyosin-1 (TPM1) (36/39kDa) antibody

Tropomyosin-1 (TPM1) Mouse IgG1 TM-33 Purified Chk, Hu, Ms, Rt WB
0.1 mg / €390.00
  OriGene Technologies GmbH

Tropomyosin-1 (TPM1) (36Da) antibody

Tropomyosin-1 (TPM1) Mouse IgG2a TM-36 Purified Chk, Hu, Ms, Rt C, ICC/IF, WB
0.1 mg / €390.00
  OriGene Technologies GmbH

Tropomyosin-1 (TPM1) (Sarcomeric) antibody

Tropomyosin-1 (TPM1) Mouse IgG1 ST-39 Purified Chk, Hu, Rb, Rt C, ICC/IF, IP, P, WB
0.1 mg / €390.00
  OriGene Technologies GmbH

3 Item(s)

per page
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