TRPC2 / TRP2 antibody

Principal name

TRPC2 / TRP2 antibody

Alternative names for TRPC2 / TRP2 antibody

Short transient receptor potential channel 2, Trrp2, Transient receptor protein 2, TRP-2, mTrp2

Gene ID

22064 (Trpc2)

Ncbi ID


Available reactivities

Ms (Mouse), Rt (Rat)

Available hosts

Sheep, Rabbit

Available applications

Frozen Sections (C), Paraffin Sections (P), Western blot / Immunoblot (WB)

Background of TRPC2 / TRP2 antibody

TRPC (transient receptor potential cation channel) channels are the closest mammalian homologs of Drosophila TRP and TRP-like channels. TRPCs are rather nonselective Ca2+ permeable cation channels and affect cell functions through their ability to mediate Ca2+ entry into cells and their action to collapse the plasma membrane potentials. The mammalian genome codes for seven TRPCs of which TRPC2 is the largest with the most restricted pattern of expression and has several altertively spliced variant. Expressed in model cells, TRPC2 mediates both receptor- and store depletion-triggered Ca2+ . In human, TPRC2 is a pseudogene. Physiological roles for TRPC2 have been studied in mature sperm and the vomerosal sensory system. In sperm, TRPC2 is activated by the sperm’s interaction with theoocyteâ??s zo pellucida, leading to entry of Ca2+ and activation of the acrosome reaction. In the vomerosal sensory organ (VNO), TRPC2 was found to constitute the transduction channel activated through sigling cascade initiated by the interaction of pheromones with V1R and V2R G protein-coupled receptors on the dendrites of the sensory neurons. TRPC2-deficient mice display abnormal mating behavior, consistent with a role for this channel in pheromone sigling.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

TRPC2 / TRP2 antibody

Western blot analysis of mouse brain lysate: 1. Anti-TRPC2 antibody, (1:200). 2. Anti-TRPC2 antibody preincubated, with the control peptide antigen. Rabbit Purified Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

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