TRPC4 / TRP4 antibody

Principal name

TRPC4 / TRP4 antibody

Alternative names for TRPC4 / TRP4 antibody

Trp-related protein 4, TRP-4, CCE1, Short transient receptor potential channel 4, Capacitative calcium entry channel 1

SwissProt ID

O35119 (Rat), P79100 (Bovin), Q9QUQ5 (Mouse), Q9UBN4 (Human)

Gene ID

7223 (TRPC4), 22066 (Trpc4), 84494

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Ms (Mouse), Por (Porcine), Rt (Rat), Eq (Equine), GP (Guinea Pig), Rb (Rabbit)

Available hosts

Rabbit, Goat, Mouse

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Immunoprecipitation (IP), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P)

Background of TRPC4 / TRP4 antibody

Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient (1). They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces.
There are a few main classifications of gated ion channels. There are voltage- gated ion channels, ligand- gated, other gating systems and finally those that are classified differently, having more exotic characteristics. The first are voltage- gated ion channels which open and close in response to membrane potential. These are then separated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels; each of which is responsible for a unique role. Ligand-gated ion channels are also known as ionotropic receptors, and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein. The other gated classifications include activation and inactivation by second messengers, inward-rectifier potassium channels, calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels and cyclic nucleotide-gated channels. Finally, the other classifications are based on less normal characteristics such as two-pore channels, and transient receptor potential channels (2).
Transient receptor potential cation channel, subfamily C, member 4, also known as TRPC4, is a human gene encoding a protein of the same name. They are expressed in smooth muscle and endothelial cells where they regulate membrane potential and calcium influx. TrpC4 is activated by G(q)/phospholipase C-coupled receptors, but the underlying mechanism remains elusive (3). Studies suggest TrpC4 contributes to axonal regeneration after nerve injury (4).

General readings

Song X, Zhao Y, Narcisse L, Duffy H, Kress Y, Lee S, Brosnan CF.
Canonical transient receptor potential channel 4 (TRPC4) co-localizes with the scaffolding protein ZO-1 in human fetal astrocytes in culture.
Glia. 2005 Feb;49(3):418-29
PMID: 15540229

  1. Quick-Filters:
  2. Highly Validated (1)

Items 1 to 20 of 25 total

per page
Page:
  1. 1
  2. 2

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

TRPC4 / TRP4 antibody

  Rabbit Polyclonal Anti-TRPC4  
Western blot analysis of rat brain membranes: 1. Anti-TRPC4 antibody, (1:200). 2. Anti-TRPC4 antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

TRPC4 / TRP4 antibody

  Goat Anti-TRPC4 Antibody  
TA305678 (0.3ug/ml) staining of Rat Brain lysate (35ug protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Bov, Can, Hu, Ms, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

TRPC4 / TRP4 antibody

  Mouse Monoclonal anti-trpc4 Antibody  
IHC analysis of TrpC4 in human hippocampal tissue using anti-trpc4. Mouse IgG2b S77-15 Purified Hu, Ms, Rt C, ICC/IF, IP, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

TRPC4 / TRP4 antibody

  Rabbit Polyclonal Anti-TRPC4 (extracellular)  
Western blot analysis of rat and mouse brain lysates: 1. Anti-TRPC4 (extracellular) antibody, (1:200). 2. Anti-TRPC4 (extracellular) antibody, preincubated with the control antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

TRPC4 / TRP4 antibody

  Rabbit Polyclonal Anti-TRPC4 Antibody  
WB Suggested Anti-TRPC4 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:312500; Positive Control: 293T cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

TRPC4 / TRP4 antibody

Adult rat brain membrane (RBM) and transfected cell immunoblot: extracts of RBM and COS cells transiently transfected with TrpC4 and probed with N77/15 TC supe. Mouse IgG2b N77/15 Supernatant Hu, Ms, Rt ICC/IF, IP, WB
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

TRPC4 / TRP4 antibody

Adult rat brain membrane (RBM) and transfected cell immunoblot: extracts of RBM and COS cells transiently transfected with TrpC4 and probed with N77/15 TC supe. Mouse IgG2b N77/15 Purified Hu, Ms, Rt ICC/IF, IP, WB
0.1 ml / €380.00
  Antibodies Incorporated

NeuroMab

TRPC4 / TRP4 (C-term) antibody

TRPC4 Antibody (C-term) (AP54360PU-N) western blot analysis in NCI-H292 cell line lysates (35 µg/lane). This demonstrates the TRPC4 antibody detected the TRPC4 protein (arrow). Rabbit Ig Aff - Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

TRPC4 / TRP4 (930-947) antibody

TRPC4 staining of adult rat hippocampus. Mouse IgG2b Supernatant Hu, Ms, Rt C, IP, WB
0.1 ml / €440.00
  Neuromics Antibodies

CRISPR

Catalog No. Species Donor Vector  

TRPC4 - human gene knockout kit via CRISPR

TRPC4 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

TRPC4 - human gene knockout kit via CRISPR

TRPC4 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

TRPC4 - human gene knockout kit via CRISPR

TRPC4 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

TRPC4 - human gene knockout kit via CRISPR

TRPC4 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Trpc4 - mouse gene knockout kit via CRISPR

Trpc4 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Trpc4 - mouse gene knockout kit via CRISPR

Trpc4 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Trpc4 - mouse gene knockout kit via CRISPR

Trpc4 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Trpc4 - mouse gene knockout kit via CRISPR

Trpc4 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, TRPC4 (mGFP-tagged)-Human transient receptor potential cation channel, subfamily C, member 4 (TRPC4), transcript variant delta, 200 uL, >10^7 TU/mL

Lenti ORF particles, TRPC4 (mGFP-tagged)-Human transient receptor potential cation channel, subfamily C, member 4 (TRPC4), transcript variant delta, 200 uL, >10^7 TU/mL  
200 µl / €1,790.00
  OriGene Technologies, Inc.

Lenti ORF particles, TRPC4 (mGFP-tagged) - Human transient receptor potential cation channel, subfamily C, member 4 (TRPC4), transcript variant epsilon, 200 uL, >10^7 TU/mL

Lenti ORF particles, TRPC4 (mGFP-tagged) - Human transient receptor potential cation channel, subfamily C, member 4 (TRPC4), transcript variant epsilon, 200 uL, >10^7 TU/mL  
200 µl / €2,020.00
  OriGene Technologies, Inc.

Lenti ORF particles, TRPC4 (mGFP-tagged)-Human transient receptor potential cation channel, subfamily C, member 4 (TRPC4), transcript variant gamma, 200 uL, >10^7 TU/mL

Lenti ORF particles, TRPC4 (mGFP-tagged)-Human transient receptor potential cation channel, subfamily C, member 4 (TRPC4), transcript variant gamma, 200 uL, >10^7 TU/mL  
200 µl / €1,770.00
  OriGene Technologies, Inc.

Items 1 to 20 of 25 total

per page
Page:
  1. 1
  2. 2
  • LinkedIn