TRPC5 / TRP5 antibody

Principal name

TRPC5 / TRP5 antibody

Alternative names for TRPC5 / TRP5 antibody

TRP-5, Short transient receptor potential channel 5, Transient receptor protein 5

SwissProt ID

O62852 (Rabit), Q9MYV9 (Bovin), Q9QX29 (Mouse), Q9UL62 (Human)

Gene ID

7224 (TRPC5), 22067 (Trpc5)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), GP (Guinea Pig), Bov (Bovine)

Available hosts

Mouse, Sheep, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Frozen Sections (C), Paraffin Sections (P), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP)

Background of TRPC5 / TRP5 antibody

Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient (1). They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces.
There are a few main classifications of gated ion channels. There are voltage- gated ion channels, ligandgated, other gating systems and finally those that are classified differently, having more exotic characteristics. The first are voltage- gated ion channels which open and close in response to membrane potential. These are then separated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels; each of which is responsible for a unique role. Ligand-gated ion channels are also known as ionotropic receptors, and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein. The other gated classifications include activation and inactivation by second messengers, inwardrectifier potassium channels, calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels and cyclic nucleotide-gated channels. Finally, the other classifications are based on less normal characteristics such as two-pore channels, and transient receptor potential channels (2).
Transient receptor potential cation channel, subfamily C, member 5, also known as TRPC5, is a subtype of the TRPC family of mammalian transient receptor potential ion channels. Homomultimeric TRPC5 and heteromultimeric TRPC5-TRPC1 channels are activated by extracellular reduced thioredoxin (3). This activation probably plays a role in rheumatoid arthritis. It has also been recently found to be involved in the action on anaesthetics such as choloform, halothane and propofol (4).

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

TRPC5 / TRP5 (827-845) antibody

IHC analysis of TrpC5 using TA309488, tested on mouse brain. Nuclear membrane staining of every cells. Mouse IgG2b S67-15 Purified Hu, Ms, Rt C, ICC/IF, IP, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

TRPC5 / TRP5 antibody

Anti-TRPC5 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 5 ug/ml. Mouse IgG2b S67-15 Purified Hu, Ms, Rt ICC/IF
50 µg / €345.00
  OriGene Technologies, Inc.

TRPC5 / TRP5 antibody

TRPC5 Antibody (N-term) (Cat. #TA324525) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the TRPC5 antibody detected the TRPC5 protein (arrow). Rabbit IgG Purified Hu, Ms, Rb P, WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

TRPC5 / TRP5 antibody

Western blot analysis of rat brain membranes: 1. Anti-TRPC5 antibody, (1:200). 2. Anti-TRPC5 antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

TRPC5 / TRP5 antibody

Adult rat brain membrane (RBM) and transfected cell immunoblot: extracts of RBM and HEK-293 cells transiently transfected with TrpC5 and Kv2.1 plasmids and probed with N67/15 (left) or K89/34 (right) TC supe. Mouse IgG2b N67/15 Supernatant Hu, Ms, Rt C, IP, WB
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

TRPC5 / TRP5 antibody

Adult rat brain membrane (RBM) and transfected cell immunoblot: extracts of RBM and HEK-293 cells transiently transfected with TrpC5 and Kv2.1 plasmids and probed with N67/15 (left) or K89/34 (right) TC supe. Mouse IgG2b N67/15 Purified Hu, Ms, Rt C, IP, WB
0.1 ml / €380.00
  Antibodies Incorporated

NeuroMab

TRPC5 / TRP5 antibody

TRPC5 / TRP5 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

TRPC5 / TRP5 antibody

Western Blot analysis of TRPC5 expression in transfected 293T cell line (H00007224-T01) by TRPC5 MaxPab polyclonal antibody.

Lane 1: TRPC5 transfected lysate(111.40 KDa).
Lane 2: Non-transfected lysate. Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

TRPC5 / TRP5 antibody

TRPC5 / TRP5 Mouse IgG2a 1C8 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

TRPC5 / TRP5 (C-term) antibody

TRPC5 / TRP5 Rabbit Aff - Purified Bov, Ms ELISA, WB
25 µg / €630.00
  Funakoshi Co., Ltd.

TRPC5 / TRP5 (C-term) antibody

TRPC5 / TRP5 Rabbit Aff - Purified Ms ELISA
25 µg / €630.00
  Funakoshi Co., Ltd.

TRPC5 / TRP5 (927-845) antibody

TRPC5 staining of cerebellar (A), reticular thalamic nucleus (B) and .hippocampal (C) tissue. Mouse IgG2b Purified GP, Hu, Ms, Rt C, ICC/IF, IP, WB
0.1 ml / €440.00
  Neuromics Antibodies

TRPC5 / TRP5 antibody

TRPC5 / TRP5 Rabbit Serum Hu, Ms, Rt C, P, WB
0.1 ml / €400.00
  Novus Biologicals Inc.

TRPC5 / TRP5 antibody

TRPC5 / TRP5 Sheep Serum Hu, Ms, Rt C, P, WB
0.1 ml / €400.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

TRPC5 / TRP5

TRPC5 / TRP5 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

TRPC5 / TRP5

TRPC5 / TRP5 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

TRPC5 overexpression lysate

TRPC5 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

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