TRPC6 / TRP6 antibody

Principal name

TRPC6 / TRP6 antibody

Alternative names for TRPC6 / TRP6 antibody

Transient receptor protein 6, TRP-6, Short transient receptor potential channel 6

SwissProt ID

Q61143 (Mouse), Q9MYW0 (Bovin), Q9Y210 (Human)

Gene ID

7225 (TRPC6), 22068 (Trpc6)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Chimp (Chimpanzee), Por (Porcine), Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Ye (Yeast), Rb (Rabbit)

Available hosts

Mouse, Rabbit, Goat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Flow Cytometry (F), Immunocytochemistry/Immunofluorescence (ICC/IF), Frozen Sections (C)

Background of TRPC6 / TRP6 antibody

TRPC6 (Transient receptor potential cation channel, subfamily C, member 6), also known as TRP6, is a transient receptor potentialion channel.TRPC6 is a novel member of the TRPC family. The predicted 931-amino acid protein shares 93% identity with mouse Trpc6. Northern blot analysis revealed that TRPC6 is expressed primarily in placenta, lung, spleen, ovary, and small intestine. The TRPC6 gene is mapped on 11q22.1. TRPC6 is a nonselective cation channel that is activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Although TRPC3, the closest structural relative of TRPC6, is activated in the same manner, human TRPC1 and mouse Trpc4 and Trpc5 were unresponsive to DAG. Immunofluorescence studies showed that most TRPC6 expression is confined to podocytes. TRPC6 was also expressed in glomerular endothelial cells. Cardiac-specific overexpression of TRPC6 in transgenic mice resulted in heightened sensitivity to stress, a propensity for lethal cardiac growth and heart failure, and an increase in Nfat-dependent expression of beta-myosin heavy chain (MYH7), a marker for pathologic hypertrophy. Studies of Trpc6 -/- mice showed that Trpc6 has a role in regulation of smooth muscle tone in blood vessels and lung.

General readings

Foller M, Kasinathan RS, Koka S, Lang C, Shumilina E, Birnbaumer L, Lang F, Huber SM.
TRPC6 contributes to the Ca(2+) leak of human erythrocytes.
Cell Physiol Biochem. 2008;21(1-3):183-92. Epub 2008 Jan 16.
PMID: 18209485

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

TRPC6 / TRP6 (C-term) antibody

  Goat Polyclonal Antibody against TRPC6 (C-terminal)  
TA303373 (0.03µg/ml) staining of Human Placenta lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Bov, Hu E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

TRPC6 / TRP6 (C-term) antibody

  Rabbit Polyclonal TRPC6 Antibody  
Western blot analysis of TRPC6 in mouse lung tissue lysate with TRPC6 antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml. Rabbit IgG Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

TRPC6 / TRP6 (N-term) antibody

  Rabbit Polyclonal TRPC6 Antibody  
Western blot analysis of TRPC6 in K562 cell lysate with TRPC6 antibody at (A) 0.5 and (B) 1 ug/ml. Rabbit IgG Aff - Purified Hu, Ms E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

TRPC6 / TRP6 antibody

  Mouse monoclonal anti-TRPC6 antibody  
Western Blot of Mouse anti-TRPC6 Antibody Lane 1: Mouse Kidney WCL Load: 10 µg per lane Primary antibody: TRPC6 Antibody at 1:1000 for overnight at 4°C Secondary antibody: DyLight™ 649 donkey anti-mouse at 1:20,000 for 30 min at RT Block: MB-070 for 30 min at RT Mouse IgG1 3F2.H10.F2 Purified Chimp, Hu E, P, WB
0.1 mg / €356.00
  OriGene Technologies, Inc.

TRPC6 / TRP6 antibody

  Anti-TRPC6 Rabbit Polyclonal Antibody  
Predicted cell location: Cytoplasm . Positive control: Human colon and gastric cancer tissue . Recommended dilution: 1/50-200  The image on the left is immunohistochemistry of paraffin-embedded human colon cancer tissue using TRPC6 antibody at dilution 1/40, on the right is treated with the synthetic peptide. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

TRPC6 / TRP6 antibody

  Anti-TRPC6 Rabbit Polyclonal Antibody  
Predicted cell location: Cytoplasm . Positive control: Human liver and lung cancer tissue . Recommended dilution: 1/50-200  The image on the left is immunohistochemistry of paraffin-embedded human liver cancer tissue using TRPC6 antibody at dilution 1/50, on the right is treated with the synthetic peptide. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

TRPC6 / TRP6 antibody

  Rabbit Polyclonal Anti-TRPC6  
Western blot analysis of rat brain membranes: 1. Anti-TRPC6 antibody, (1:200). 2. Anti-TRPC6 antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

TRPC6 / TRP6 antibody

  Rabbit Polyclonal Anti-TRPC6 (extracellular)  
Western blot analysis of rat brain lysates: 1. Anti-TRPC6 (extracellular) antibody, (1:200). 2. Anti-TRPC6 (extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

TRPC6 / TRP6 antibody

  Rabbit Polyclonal Anti-TRPC6 Antibody  
WB Suggested Anti-TRPC6 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:312500; Positive Control: MCF7 cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rt, Ye WB
50 µg / €325.00
  OriGene Technologies, Inc.

TRPC6 / TRP6 antibody

  Rabbit Polyclonal Anti-TRPC6 Antibody  
WB Suggested Anti-TRPC6 Antibody Titration: 2.5 ug/ml; Positive Control: HepG2 cell lysate Rabbit IgG Purified Eq, Hu, Por P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

TRPC6 / TRP6 antibody

  Rabbit Polyclonal Anti-TRPC6 Antibody - N-terminal region  
WB Suggested Anti-TRPC6 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:1562500; Positive Control: MCF7 cell lysate Rabbit IgG Purified Eq, Hu, Ms, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

TRPC6 / TRP6 antibody

Figure 1. Staining TRPC6 in Placenta by Immunohistochemistry using Formalin-Fixed Paraffin-Embedded (FFPE) tissue. Rabbit Purified Hu, Ms, Rt P, WB
50 µg / €470.00
  Acris Antibodies GmbH

TRPC6 / TRP6 antibody

Western blot analysis of extracts from A549 and Mouse brain tissue using TRPC6 Antibody Cat.-No AP08080PU Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 ml / €320.00
  Acris Antibodies GmbH

TRPC6 / TRP6 antibody

Western blot analysis of extracts from A549 and Mouse brain tissue using TRPC6 Antibody Cat.-No AP08080PU Rabbit Aff - Purified Hu, Ms, Rt WB
50 µl / €240.00
  Acris Antibodies GmbH

TRPC6 / TRP6 (C-term) antibody

TRPC6 / TRP6 Goat Aff - Purified Bov, Can, Hu, Ms, Por E, F
0.1 mg / €350.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

TRPC6 - human gene knockout kit via CRISPR

TRPC6 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

TRPC6 - human gene knockout kit via CRISPR

TRPC6 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

TRPC6 - human gene knockout kit via CRISPR

TRPC6 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

TRPC6 - human gene knockout kit via CRISPR

TRPC6 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Trpc6 - mouse gene knockout kit via CRISPR

Trpc6 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

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