TRPC7 / TRP7 antibody

Principal name

TRPC7 / TRP7 antibody

Alternative names for TRPC7 / TRP7 antibody

TRP-7, Short transient receptor potential channel 7

SwissProt ID

Q9HCX4 (Human), Q9WVC5 (Mouse)

Gene ID

57113 (TRPC7)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Can (Canine), Chk (Chicken), Bov (Bovine), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit), Ze (Zebrafish)

Available hosts

Sheep, Mouse, Goat, Rabbit

Available applications

Frozen Sections (C), Paraffin Sections (P), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Enzyme Immunoassay (E)

Background of TRPC7 / TRP7 antibody

Transient receptor potential (TRP) channels are relatively non-selective ion channels ebling the exchange of cations down their electrochemical gradient. This exchange ebles the intracellular rise in + and Ca2+ concentration and ultimately in the cell membrane depolarization, important for action potential propagation and muscle contraction. They are activated by an extremely broad range of stimuli mely, temperature, voltage, pH, endocrine factors as well as sigling molecules. The TRP channel family is composed of 28 members divided in 7 subgroups: TRPV, TRPC, TRPM, TRPA, TRPN, TRPP and TRPML. All members of the TRP family form tetramers and could heterhomultimerize. They have 6 transmembrane (TM) domains, and a pore domain between the fifth (S5) and sixth (S6) transmembrane domains. In general, TRP channels eble the passage of either + or Ca2+ ions with little or no preference. However, some channels do exhibit some selectivity. Also, TRP channels do not display the positive charges in the S4 voltage-sensing domain like most voltage sensitive channels, although they do display voltage dependency. In addition, TRP channels have in the C-termil intracellular region to the S6 domain a TRP domain comprising 25 amino acids that is more or less conserved among most TRP channels. Within the TRP domain, there is a TRP box composed of six amino acids, and TRP box 2 – a proline rich domain. The TRP domain seems to be responsible for the binding of PIP2, a phospholipid important for the regulation of channel activity. The TRPC subfamily is further divided into the following: TRPC1/4/5, TRPC3/6/7 and TRPC2. Activation of phospholipase C (PLC) ultimately leads to the formation of diacylglycerol (DAG) and inositol 1,4,5-triphosphate (IP3) via hydrolysis of PIP2. The increase in concentration of these intracellular second messengers leads to the activation of non-selective Ca2+ channels and an IP3-induced release of Ca2+ from intracellular stores. The intracellular Ca2+ store depletion in turn activates Ca2+ specific channels to allow replenish intracellular Ca2+ levels. TRPCs are thought to be activated upon intracellular store Ca2+ depletion, and may function in concert along with the recently identified Orai channel. The TRPC3/6/7 class produces similar currents upon activation. TRPC7 is activated by a broad range of hormones and neurotrophins, many of which activate PLC dependent pathways, via G-protein coupled receptors (GPCRs) or receptor tyrosine kises (RTKs). Its expression is has been detected in dorsal root ganglia (DRGs), heart, uterine myometrium, keratinocytes and leukemic cells. In myocardial cells, TRPC7 has recently been shown to promote apoptosis, thereby becoming a contributing factor in the development of heart disease. Indeed, there is a strong correlation between the high expression level of TRPC7 and apoptosis in hearts from Dahl salt-sensitive rats which have suffered from heart failure.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

TRPC7 / TRP7 antibody

Predicted cell location: Cytoplasm. Positive control: Human colon and thyroid cancer tissue. Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded human colon cancer tissue using TRPC7 antibody at dilution 1/25, on the right is treated with the fusion protein. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

TRPC7 / TRP7 (845-862) antibody

Western blot analysis of TrpC7 in rat brain membrane lysates using a 1:1000 dilution of the antibody Mouse IgG1 S64A-36 Purified Hu, Ms, Rt C, ICC/IF, IP, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

TRPC7 / TRP7 antibody

Western blot analysis of mouse brain membrane (lanes 1 and 2) and rat brain lysate (lanes 3 and 4): 1, 3. Anti-TRPC7 (extracellular) antibody, (1:200). 2, 4. Anti-TRPC7 (extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

TRPC7 / TRP7 antibody

Host: Rabbit; Target Name: TRPC7; Sample Tissue: Breast Tumor lysates; Antibody Dilution: 1.0 ug/ml Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

TRPC7 / TRP7 antibody

Adult rat hippocampus immunohistochemistry. Mouse IgG1 N64A/36 Supernatant Hu, Ms, Rt C, IP, WB
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

TRPC7 / TRP7 antibody

Adult rat hippocampus immunohistochemistry. Mouse IgG1 N64A/36 Purified Hu, Ms, Rt C, IP, WB
0.1 ml / €380.00
  Antibodies Incorporated

NeuroMab

TRPC7 / TRP7 antibody

TRPC7 / TRP7 Goat Aff - Purified Can, Hu, Ms, Rt E, IP, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

TRPC7 / TRP7 (C-term) antibody

TRPC7 Antibody (C-term) (AP54361PU-N) western blot analysis in CEM cell line lysates (35 µg/lane). This demonstrates the TRPC7 antibody detected the TRPC7 protein (arrow). Rabbit Ig Aff - Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

TRPC7 / TRP7 antibody

TRPC7 / TRP7 Sheep Serum Hu, Ms C, P, WB
0.1 ml / €400.00
  Novus Biologicals Inc.

TRPC7 / TRP7 antibody

TRPC7 / TRP7 Goat Aff - Purified Chk E, IP, WB
0.1 mg / €400.00
  Novus Biologicals Inc.

TRPC7 / TRP7 antibody

TRPC7 / TRP7 Rabbit Purified Hu, Ms C, P, WB
0.1 ml / €400.00
  Novus Biologicals Inc.

TRPC7 / TRP7 antibody

TRPC7 / TRP7 Mouse IgG1 S64A-36 Purified Hu, Ms, Rt IP, P, WB
0.1 mg / €450.00
  Novus Biologicals Inc.

12 Item(s)

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