TRPM3 / Melastatin-2 antibody

Principal name

TRPM3 / Melastatin-2 antibody

Alternative names for TRPM3 / Melastatin-2 antibody

KIAA1616, LTRPC3, Long transient receptor potential channel 3, Transient receptor potential cation channel subfamily M member 3

SwissProt ID

Q9HCF6 (Human)

Gene ID

80036 (TRPM3)

Available reactivities

Bov (Bovine), Hu (Human), Ms (Mouse), Rt (Rat), Ze (Zebrafish), Can (Canine), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit)

Available hosts

Rabbit

Available applications

Western blot / Immunoblot (WB), Frozen Sections (C), Enzyme Immunoassay (E), Paraffin Sections (P)

Background of TRPM3 / Melastatin-2 antibody

Transient receptor potential (TRP) channels are relatively non-selective ion channels ebling the exchange of cations down their electrochemical gradient. This exchange ebles the intracellular rise in + and Ca2+ concentration and ultimately in the cell membrane depolarization, important for action potential propagation and muscle contraction. They are activated by an extremely broad range of stimuli mely, temperature, voltage, pH, endocrine factors as well as sigling molecules. The TRP channel family is composed of 28 members divided in 7 subgroups: TRPV, TRPC, TRPM, TRPA, TRPN, TRPP and TRPML. All members of the TRP family have 6 transmembrane (TM) domains, and a pore domain between the fifth (S5) and sixth (S6) transmembrane domains. In general, TRP channels eble the passage of either + or Ca2+ ions with little or no preference. However, some channels do exhibit some selectivity. Also, TRP channels do not display the positive charges in the S4 voltage-sensing domain like most voltage sensitive channels, although they do display voltage dependency. In addition, TRP channels have in the C-termil intracellular region to the S6 domain a TRP domain comprising 25 amino acids that is more or less conserved among most TRP channels. Within the TRP domain, there is a TRP box composed of six amino acids, and TRP box 2 â?? a proline rich domain. The TRP domain seems to be responsible for the binding of PIP2, a phospholipid important for the regulation of channel activity. The TRPM subfamily consists of 8 members divided in to three major groups: TRPM1/3, TRPM4/5, and TRPM6/7. TRPM2 and TRPM8 are not included in any of the groups since they are quite different even with respect to each other. TRPM3 is altertively spliced into active variants. TRPM3a1 and TRPM3a2 in mouse are monovalent and divalent-selective channels, respectively. This differential selectivity strongly suggests that their cellular role depends on the relative expression of each variant type. In addition, both splice variants display constitutive outwardly rectifying currents. They somewhat resemble TRPM6 and TRPM7 channels such that their currents are inhibited by intracellular Mg2+ . TRPM3 is highly expressed in the kidney, and to a lesser extent in the brain, testis, and spil cord.

General readings

Oberwinkler,J., et al., (2005) J. Biol. Chem. 280 (23), 22540-22548

Items 1 to 20 of 24 total

per page
Page:
  1. 1
  2. 2

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

TRPM3 / Melastatin-2 antibody

  Rabbit Polyclonal Anti-TRPM3 (extracellular)  
Western blot analysis of rat brain membrane (lanes 1 and 4), rat brain lysate (lanes 2 and 5) and mouse brain lysate (lanes 3 and 6): 1-3.Anti-TRPM3 (extracellular) antibody, (1:200). 4-6. Anti-TRPM3 (extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

TRPM3 / Melastatin-2 antibody

  Rabbit Polyclonal Anti-TRPM3 Antibody  
WB Suggested Anti-TRPM3 Antibody Titration: 1.25 ug/ml; Positive Control: HepG2 cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

TRPM3 / Melastatin-2 antibody

  Rabbit Polyclonal Anti-TRPM3 Antibody  
WB Suggested Anti-TRPM3 Antibody Titration: 1.25 ug/ml; ELISA Titer: 1:1562500; Positive Control: Human cerebellum Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rb, Rt, Ze WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

TRPM3 / Melastatin-2 antibody

  Rabbit Polyclonal Anti-TRPM3 Antibody  
WB Suggested Anti-TRPM3 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:1562500; Positive Control: Jurkat cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

TRPM3 / Melastatin-2 antibody

  Rabbit Polyclonal Anti-TRPM3 Antibody  
TRPM3 / Melastatin-2 Rabbit IgG Purified Hu E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

TRPM3 / Melastatin-2 antibody

TRPM3 / Melastatin-2 Rabbit Purified Hu, Ms, Rt C, E, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

TRPM3 - human gene knockout kit via CRISPR

TRPM3 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

TRPM3 - human gene knockout kit via CRISPR

TRPM3 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

TRPM3 - human gene knockout kit via CRISPR

TRPM3 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

TRPM3 - human gene knockout kit via CRISPR

TRPM3 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, TRPM3 (mGFP-tagged)-Human transient receptor potential cation channel, subfamily M, member 3 (TRPM3), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, TRPM3 (mGFP-tagged)-Human transient receptor potential cation channel, subfamily M, member 3 (TRPM3), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €2,530.00
  OriGene Technologies, Inc.

Lenti ORF particles, TRPM3 (mGFP-tagged) - Human transient receptor potential cation channel, subfamily M, member 3 (TRPM3), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, TRPM3 (mGFP-tagged) - Human transient receptor potential cation channel, subfamily M, member 3 (TRPM3), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €2,530.00
  OriGene Technologies, Inc.

Lenti ORF particles, TRPM3 (mGFP-tagged)-Human transient receptor potential cation channel, subfamily M, member 3 (TRPM3), transcript variant 3, 200 uL, >10^7 TU/mL

Lenti ORF particles, TRPM3 (mGFP-tagged)-Human transient receptor potential cation channel, subfamily M, member 3 (TRPM3), transcript variant 3, 200 uL, >10^7 TU/mL  
200 µl / €2,530.00
  OriGene Technologies, Inc.

Lenti ORF particles, TRPM3 (mGFP-tagged)-Human transient receptor potential cation channel, subfamily M, member 3 (TRPM3), transcript variant 5, 200 uL, >10^7 TU/mL

Lenti ORF particles, TRPM3 (mGFP-tagged)-Human transient receptor potential cation channel, subfamily M, member 3 (TRPM3), transcript variant 5, 200 uL, >10^7 TU/mL  
200 µl / €2,530.00
  OriGene Technologies, Inc.

Lenti ORF particles, TRPM3 (mGFP-tagged)-Human transient receptor potential cation channel, subfamily M, member 3 (TRPM3), transcript variant 6, 200 uL, >10^7 TU/mL

Lenti ORF particles, TRPM3 (mGFP-tagged)-Human transient receptor potential cation channel, subfamily M, member 3 (TRPM3), transcript variant 6, 200 uL, >10^7 TU/mL  
200 µl / €2,530.00
  OriGene Technologies, Inc.

Lenti ORF particles, TRPM3 (mGFP-tagged)-Human transient receptor potential cation channel, subfamily M, member 3 (TRPM3), transcript variant 7, 200 uL, >10^7 TU/mL

Lenti ORF particles, TRPM3 (mGFP-tagged)-Human transient receptor potential cation channel, subfamily M, member 3 (TRPM3), transcript variant 7, 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, TRPM3 (mGFP-tagged)-Human transient receptor potential cation channel, subfamily M, member 3 (TRPM3), transcript variant 8, 200 uL, >10^7 TU/mL

Lenti ORF particles, TRPM3 (mGFP-tagged)-Human transient receptor potential cation channel, subfamily M, member 3 (TRPM3), transcript variant 8, 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, TRPM3 (Myc-DDK-tagged)-Human transient receptor potential cation channel, subfamily M, member 3 (TRPM3), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, TRPM3 (Myc-DDK-tagged)-Human transient receptor potential cation channel, subfamily M, member 3 (TRPM3), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €2,280.00
  OriGene Technologies, Inc.

Lenti ORF particles, TRPM3 (Myc-DDK tagged) - Human transient receptor potential cation channel, subfamily M, member 3 (TRPM3), transcript variant 2 , 200 uL, >10^7 TU/mL

Lenti ORF particles, TRPM3 (Myc-DDK tagged) - Human transient receptor potential cation channel, subfamily M, member 3 (TRPM3), transcript variant 2 , 200 uL, >10^7 TU/mL  
200 µl / €2,280.00
  OriGene Technologies, Inc.

Lenti ORF particles, TRPM3 (Myc-DDK-tagged)-Human transient receptor potential cation channel, subfamily M, member 3 (TRPM3), transcript variant 3, 200 uL, >10^7 TU/mL

Lenti ORF particles, TRPM3 (Myc-DDK-tagged)-Human transient receptor potential cation channel, subfamily M, member 3 (TRPM3), transcript variant 3, 200 uL, >10^7 TU/mL  
200 µl / €2,280.00
  OriGene Technologies, Inc.

Items 1 to 20 of 24 total

per page
Page:
  1. 1
  2. 2
  • LinkedIn