TRPM3 / Melastatin-2 antibody

Principal name

TRPM3 / Melastatin-2 antibody

Alternative names for TRPM3 / Melastatin-2 antibody

KIAA1616, LTRPC3, Long transient receptor potential channel 3, Transient receptor potential cation channel subfamily M member 3

SwissProt ID

Q9HCF6 (Human)

Gene ID

80036 (TRPM3)

Available reactivities

Bov (Bovine), Hu (Human), Ms (Mouse), Rt (Rat), Ze (Zebrafish), Can (Canine), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit)

Available hosts

Rabbit, Sheep, Goat

Available applications

Western blot / Immunoblot (WB), Frozen Sections (C), Paraffin Sections (P), Enzyme Immunoassay (E)

Background of TRPM3 / Melastatin-2 antibody

Transient receptor potential (TRP) channels are relatively non-selective ion channels ebling the exchange of cations down their electrochemical gradient. This exchange ebles the intracellular rise in + and Ca2+ concentration and ultimately in the cell membrane depolarization, important for action potential propagation and muscle contraction. They are activated by an extremely broad range of stimuli mely, temperature, voltage, pH, endocrine factors as well as sigling molecules. The TRP channel family is composed of 28 members divided in 7 subgroups: TRPV, TRPC, TRPM, TRPA, TRPN, TRPP and TRPML. All members of the TRP family have 6 transmembrane (TM) domains, and a pore domain between the fifth (S5) and sixth (S6) transmembrane domains. In general, TRP channels eble the passage of either + or Ca2+ ions with little or no preference. However, some channels do exhibit some selectivity. Also, TRP channels do not display the positive charges in the S4 voltage-sensing domain like most voltage sensitive channels, although they do display voltage dependency. In addition, TRP channels have in the C-termil intracellular region to the S6 domain a TRP domain comprising 25 amino acids that is more or less conserved among most TRP channels. Within the TRP domain, there is a TRP box composed of six amino acids, and TRP box 2 â?? a proline rich domain. The TRP domain seems to be responsible for the binding of PIP2, a phospholipid important for the regulation of channel activity. The TRPM subfamily consists of 8 members divided in to three major groups: TRPM1/3, TRPM4/5, and TRPM6/7. TRPM2 and TRPM8 are not included in any of the groups since they are quite different even with respect to each other. TRPM3 is altertively spliced into active variants. TRPM3a1 and TRPM3a2 in mouse are monovalent and divalent-selective channels, respectively. This differential selectivity strongly suggests that their cellular role depends on the relative expression of each variant type. In addition, both splice variants display constitutive outwardly rectifying currents. They somewhat resemble TRPM6 and TRPM7 channels such that their currents are inhibited by intracellular Mg2+ . TRPM3 is highly expressed in the kidney, and to a lesser extent in the brain, testis, and spil cord.

General readings

Oberwinkler,J., et al., (2005) J. Biol. Chem. 280 (23), 22540-22548

13 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

TRPM3 / Melastatin-2 antibody

Western blot analysis of rat brain membrane (lanes 1 and 4), rat brain lysate (lanes 2 and 5) and mouse brain lysate (lanes 3 and 6): 1-3.Anti-TRPM3 (extracellular) antibody, (1:200). 4-6. Anti-TRPM3 (extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

TRPM3 / Melastatin-2 antibody

WB Suggested Anti-TRPM3 Antibody Titration: 1.25 ug/ml; Positive Control: HepG2 cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

TRPM3 / Melastatin-2 antibody

WB Suggested Anti-TRPM3 Antibody Titration: 1.25 ug/ml; ELISA Titer: 1:1562500; Positive Control: Human cerebellum Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rb, Rt, Ze WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

TRPM3 / Melastatin-2 antibody

WB Suggested Anti-TRPM3 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:1562500; Positive Control: Jurkat cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

TRPM3 / Melastatin-2 antibody

TRPM3 / Melastatin-2 Rabbit Purified Hu, Ms, Rt C, E, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

TRPM3 / Melastatin-2 antibody

Human HepG2; WB Suggested Anti-TRPM3 Antibody Titration: 1.25ug/ml. Positive Control: HepG2 cell lysate; TRPM3 antibody - N-terminal region (ARP35609_T100) in Human HepG2 cells using Western Blot Rabbit Purified Bov, Can, Hu, Ms, Rt, Ze WB
0.1 mg / €310.00
  AVIVA Systems Biology

TRPM3 / Melastatin-2 antibody

Human Cerebellum; WB Suggested Anti-TRPM3 Antibody Titration: 1.25ug/ml. ELISA Titer: 1:1562500. Positive Control: Human cerebellum; TRPM3 antibody - N-terminal region (ARP36768_T100) in Human Cerebellum cells using Western Blot Rabbit IgG Purified Hu, Ms WB
0.1 mg / €310.00
  AVIVA Systems Biology

TRPM3 / Melastatin-2 antibody

Human Jurkat; WB Suggested Anti-TRPM3 Antibody Titration: 2.5ug/ml. ELISA Titer: 1:312500. Positive Control: Jurkat cell lysate; TRPM3 antibody - N-terminal region (ARP36771_T100) in Human Jurkat cells using Western Blot Rabbit IgG Purified Hu, Ms WB
0.1 mg / €310.00
  AVIVA Systems Biology

TRPM3 / Melastatin-2 antibody

Human Jurkat; WB Suggested Anti-TRPM3 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:1562500. Positive Control: Jurkat cell lysate; TRPM3 antibody - N-terminal region (ARP36776_P050) in Human Jurkat cells using Western Blot Rabbit Aff - Purified Bov, Hu, Ms, Rt, Ze WB
50 µg / €350.00
  AVIVA Systems Biology

TRPM3 / Melastatin-2 antibody

TRPM3 / Melastatin-2 Rabbit Serum Hu, Ms, Rt P, WB
0.1 ml / €400.00
  Novus Biologicals Inc.

TRPM3 / Melastatin-2 antibody

TRPM3 / Melastatin-2 Sheep Serum Hu C, P, WB
0.1 ml / €400.00
  Novus Biologicals Inc.

TRPM3 / Melastatin-2 antibody

TRPM3 / Melastatin-2 Goat Purified Hu, Ms, Rt C, P, WB
0.1 ml / €400.00
  Novus Biologicals Inc.

Western Blot/IP/ChiP Kits

Catalog No. Host Iso. Clone Pres. React. Applications  

TRPM3 Western Blot Kit

TRPM3 Western Blot Kit Hu
25 Western Blots/kit / €640.00
  AVIVA Systems Biology

13 Item(s)

per page
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