TRPM5 antibody

Principal name

TRPM5 antibody

Alternative names for TRPM5 antibody

TRPM-5, LTRPC5, MTR1, Long transient receptor potential channel 5, LTrpC5, MLSN1- and TRP-related gene 1 protein, Transient receptor potential cation channel subfamily M member 5

SwissProt ID

Q9JJH7 (Mouse), Q9NZQ8 (Human)

Gene ID

29850 (TRPM5), 56843 (Trpm5)

Available reactivities

Can (Canine), Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E)

Background of TRPM5 antibody

The mammalian melastatin-related transient receptor potential (TRPM) is a subfamily of the TRP family. The family was med after the first discovered member, melastatin (TRPM1) whose gene was identified in metastatic and benign melanomas. The TRPM family consists of eight members desigted as TRPM1-8 that can be further divided into four pairs: TRPM1 and TRPM3; TRPM2 and TRPM8; TRPM4 and TRPM5; and TRPM6 and TRPM7. The TRPM proteins share structural homology with other members of the TRP superfamily channels; six putative transmembrane domains, and cytoplasmic N- and C-termini. However, due to their long N- and C-termini they are also med the long TRP channel family. TRPM4 and TRPM5 are the only TRP channels that are permeable to monovalent cations but not to Ca2+. TRPM4 is expressed as at least two altertive spliced isoforms, TRPM4a and TRPM4b which consist of shorter and longer N-termil regions, respectively. TRPM4a displays little activity, TRPM4b and TRPM5 appear to be directly activated by an increase in intracellular Ca2+ concentration4,5. TRPM5 is primarily expressed in taste buds and also in stomach, small intestine, uterus and testes. Regulation of TRPM5 by G-protein-coupled receptors and PLC-mediated IP3 production has been substantiated by the colocalization of TRPM5, of a taste-cell-specific PLC isoform and of receptors for sweet, bitter and amino acid (umami) tastes in taste tissue. It has furthermore been shown that desensitization of TRPM5 following receptor stimulation can be reversed by phosphatidylinositol (4,5)-bisphosphate (PIP2), the substrate of PLC.

General readings

Liu,D., (2005) J. Biol. Chem. 280 (21), 20691-20699

9 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

TRPM5 antibody

Predicted cell location: Cytoplasm . Positive control: Human thyroid and gastric cancer tissue . Recommended dilution: 1/50-200  The image on the left is immunohistochemistry of paraffin-embedded human thyroid cancer tissue using TRPM5 antibody at dilution 1/60, on the right is treated with the synthetic peptide. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

TRPM5 antibody

Western blot analysis of rat lung membrane (lanes 1 and 2), rat testes (lanes 3 and 4), mouse ms1 cells (lanes 5 and 7) and human LNCaP cell (lanes 6 and 8) lysates: 1, 3, 5, 6. Anti-TRPM5 antibody, (1:200). 2, 4, 7, 8. Anti-TRPM5 antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

TRPM5 antibody

Human Pancreas; Immunohistochemistry with Pancreas tissue at an antibody concentration of 5ug/ml using anti-TRPM5 antibody (ARP35242_P050); TRPM5 antibody - N-terminal region (ARP35242_P050) in Human Pancreas cells using Immunohistochemistry Rabbit Aff - Purified Can, Hu, Ms WB
50 µg / €350.00
  AVIVA Systems Biology

TRPM5 antibody

Human Intestine; TRPM5 antibody - N-terminal region (ARP35243_T100) in Human Intestine cells using Immunohistochemistry Rabbit Aff - Purified Can, Hu, Ms P, WB
0.1 mg / €310.00
  AVIVA Systems Biology

Lysates

Catalog No.    

TRPM5 overexpression lysate

TRPM5 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, TRPM5 (mGFP-tagged)-Human transient receptor potential cation channel, subfamily M, member 5 (TRPM5), 200 uL, >10^7 TU/mL

Lenti ORF particles, TRPM5 (mGFP-tagged)-Human transient receptor potential cation channel, subfamily M, member 5 (TRPM5), 200 uL, >10^7 TU/mL  
200 µl / €2,310.00
  OriGene Technologies, Inc.

Lenti ORF particles, TRPM5 (Myc-DDK-tagged)-Human transient receptor potential cation channel, subfamily M, member 5 (TRPM5), 200 uL, >10^7 TU/mL

Lenti ORF particles, TRPM5 (Myc-DDK-tagged)-Human transient receptor potential cation channel, subfamily M, member 5 (TRPM5), 200 uL, >10^7 TU/mL  
200 µl / €2,080.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Trpm5 (GFP-tagged) - Mouse transient receptor potential cation channel, subfamily M, member 5 (Trpm5), 200 uL, >10^7 TU/mL

Lenti ORF particles, Trpm5 (GFP-tagged) - Mouse transient receptor potential cation channel, subfamily M, member 5 (Trpm5), 200 uL, >10^7 TU/mL  
200 µl / €1,990.00
  OriGene Technologies, Inc.

Lenti ORF particles, Trpm5 (Myc-DDK-tagged) - Mouse transient receptor potential cation channel, subfamily M, member 5 (Trpm5), 200 uL, >10^7 TU/mL

Lenti ORF particles, Trpm5 (Myc-DDK-tagged) - Mouse transient receptor potential cation channel, subfamily M, member 5 (Trpm5), 200 uL, >10^7 TU/mL  
200 µl / €1,790.00
  OriGene Technologies, Inc.

9 Item(s)

per page
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