TRPM5 antibody

Principal name

TRPM5 antibody

Alternative names for TRPM5 antibody

TRPM-5, LTRPC5, MTR1, Long transient receptor potential channel 5, LTrpC5, MLSN1- and TRP-related gene 1 protein, Transient receptor potential cation channel subfamily M member 5

SwissProt ID

Q9JJH7 (Mouse), Q9NZQ8 (Human)

Gene ID

29850 (TRPM5), 56843 (Trpm5)

Available reactivities

Can (Canine), Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit, Goat

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Frozen Sections (C), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of TRPM5 antibody

FUNCTION: Voltage-modulated Ca(2+)-activated, monovalent cation channel (VCAM) that mediates a transient membrane depolarization and plays a central role in taste transduction. Monovalent-specific, non-selective cation channel that mediates the transport of Na(+), K(+) and Cs(+) ions equally well. Activated directly by increases in intracellular Ca(2+), but is impermeable to it. Gating is voltage-dependent and displays rapid activation and deactivation kinetics upon channel stimulation even during sustained elevations in Ca(2+). Also activated by a fast intracellular Ca(2+) increase in response to inositol 1,4,5-triphosphate-producing receptor agonists. The channel is blocked by extracellular acidification. External acidification has 2 effects, a fast reversible block of the current and a slower irreversible enhancement of current inactivation. Is a highly temperature-sensitive, heat activated channel showing a steep increase of inward currents at temperatures between 15 and 35 degrees Celsius. Heat activation is due to a shift of the voltage-dependent activation curve to negative potentials. Activated by arachidonic acid in vitro. May be involved in perception of bitter, sweet and umami tastes. May also be involved in sensing semiochemicals. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Strongly expressed in fetal brain, liver and kidney, and in adult prostate, testis, ovary, colon and peripheral blood leukocytes. Also expressed in a large proportion of Wilms' tumors and rhabdomyosarcomas. In monochromosomal cell lines shows exclusive paternal expression.

General readings

Lin W, Ezekwe EA, Zhao Z, Liman ER, Restrepo D.: TRPM5-expressing microvillous cells in the main olfactory epithelium. BMC neuroscience 2008 Nov 9 (1): 114. PMID: 19025635

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

TRPM5 antibody

(1ug/ml) staining of Human Pancreas lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

TRPM5 antibody

Predicted cell location: Cytoplasm . Positive control: Human thyroid and gastric cancer tissue . Recommended dilution: 1/50-200  The image on the left is immunohistochemistry of paraffin-embedded human thyroid cancer tissue using TRPM5 antibody at dilution 1/60, on the right is treated with the synthetic peptide. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

TRPM5 antibody

Western blot analysis of rat lung membrane (lanes 1 and 2), rat testes (lanes 3 and 4), mouse ms1 cells (lanes 5 and 7) and human LNCaP cell (lanes 6 and 8) lysates: 1, 3, 5, 6. Anti-TRPM5 antibody, (1:200). 2, 4, 7, 8. Anti-TRPM5 antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

TRPM5 antibody

Human Pancreas; Immunohistochemistry with Pancreas tissue at an antibody concentration of 5ug/ml using anti-TRPM5 antibody (ARP35242_P050); TRPM5 antibody - N-terminal region (ARP35242_P050) in Human Pancreas cells using Immunohistochemistry Rabbit Aff - Purified Can, Hu, Ms WB
50 µg / €350.00
  AVIVA Systems Biology

TRPM5 antibody

Human Intestine; TRPM5 antibody - N-terminal region (ARP35243_T100) in Human Intestine cells using Immunohistochemistry Rabbit Aff - Purified Can, Hu, Ms P, WB
0.1 mg / €310.00
  AVIVA Systems Biology

TRPM5 antibody

TRPM5 Rabbit Serum Rt C, P, WB
0.1 ml / €400.00
  Novus Biologicals Inc.

TRPM5 antibody

TRPM5 Goat Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €400.00
  Novus Biologicals Inc.

Lysates (Overexpressed)

Catalog No.    

TRPM5 overexpression lysate

TRPM5 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

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