TRPM6 / CHAK2 antibody

Principal name

TRPM6 / CHAK2 antibody

Alternative names for TRPM6 / CHAK2 antibody

Channel kinase 2, Transient receptor potential cation channel subfamily M member 6, Melastatin-related TRP cation channel 6

SwissProt ID

Q8CIR4 (Mouse), Q9BX84 (Human)

Gene ID

140803 (TRPM6), 225997 (Trpm6)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Guinea Pig, Sheep, Rabbit

Available applications

Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Western blot / Immunoblot (WB), Enzyme Immunoassay (E)

Background of TRPM6 / CHAK2 antibody

Transient receptor potential (TRP) channels are relatively non-selective ion channels ebling the exchange of cations down their electrochemical gradient. This exchange ebles the intracellular rise in + and Ca2+ concentration and ultimately in the cell membrane depolarization, important for action potential propagation and muscle contraction. They are activated by an extremely broad range of stimuli mely, temperature, voltage, pH, endocrine factors as well as sigling molecules. The TRP channel family is composed of 28 members divided in 7 subgroups: TRPV, TRPC, TRPM, TRPA, TRPN, TRPP and TRPML. All members of the TRP family have 6 transmembrane (TM) domains, and a pore domain between the fifth (S5) and sixth (S6) transmembrane domains. In general, TRP channels eble the passage of either + or Ca2+ ions with little or no preference. However, some channels do exhibit some selectivity. Also, TRP channels do not display the positive charges in the S4 voltage-sensing domain like most voltage sensitive channels, although they do display voltage dependency. In addition, TRP channels have in the C-termil intracellular region to the S6 domain a TRP domain comprising 25 amino acids that is more or less conserved among most TRP channels. Within the TRP domain, there is a TRP box composed of six amino acids, and TRP box 2 – a proline rich domain. The TRP domain seems to be responsible for the binding of PIP2, a phospholipid important for the regulation of channel activity. The TRPM subfamily consists of 8 members divided in to three major groups: TRPM1/3, TRPM4/5, and TRPM6/7. TRPM2 and TRPM8 are not included in any of the groups since they are quite different even with respect to each other. TRPM2, TRPM6 and TRPM7 are distinctly different from the other TRP channels and other ion channels as all three have an active kise domain in the C-termil tail. TRPM6 kise domain is able to phosphorylate TRPM7 thus increasing TRPM7 channel activity. However, TRPM7 cannot phosphorylate TRPM6; it can though autophosphorylate and phosphorylate other proteins. The significance of the kise activity of these two channels has yet to be determined. Both channels are regulated by cytosolic Mg2+. Extracellular Mg2+ inhibits the channels. Both TRPM6 and TRPM7 are thus important regulators of Mg2+ homeostasis. TRPM7 does so in a more or less ubiquitous manner whereas TRPM6 does so selectively in the kidney and intestines where it is selectively expressed. Indeed, mutations in TRPM6 results in hypomagnesemia with secondary hypocalcemia. TRPM6 and TRPM7 are able to form homo- and heterodimers, where every channel-type formed demonstrates different properties related to cation affinity, and pH sensitivity.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

TRPM6 / CHAK2 antibody

Western blot analysis of rat kidney (lanes 1 and 4), rat testis (lanes 2 and 5) and mouse kidney (lanes 3 and 6) lysates: 1-3. Anti-TRPM6 (extracellular) antibody , (1:200). 4-6. Anti-TRPM6 (extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

TRPM6 / CHAK2 antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with TRPM6 polyclonal antibody ( Cat # PAB3252 ) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma. Rabbit Hu E, P
0.4 ml / €390.00
  Abnova Taiwan Corp.

TRPM6 / CHAK2 antibody

TRPM6 staining cryostat section of rat kidney. Tissues were stained with using Cy3-conjugated secondary antibodies. Guinea Pig Serum C, ICC/IF
0.1 mg / €310.00
  Neuromics Antibodies

TRPM6 / CHAK2 antibody

TRPM6 / CHAK2 Rabbit Serum Hu C, P, WB
0.1 ml / €400.00
  Novus Biologicals Inc.

TRPM6 / CHAK2 antibody

TRPM6 / CHAK2 Sheep Serum Hu C, P, WB
0.1 ml / €400.00
  Novus Biologicals Inc.

TRPM6 / CHAK2 antibody

Immunohistochemistry-Paraffin: TRPM6 Antibody [NBP1-85640] - Immunohistochemistry-Paraffin: TRPM6 Antibody [NBP1-85640] Immunohistochemical staining of human kidney shows strong cytoplasmic positivity in cells in tubules. Rabbit IgG Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

6 Item(s)

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