TRPM7 antibody

Principal name

TRPM7 antibody

Alternative names for TRPM7 antibody

CHAK1, LTRPC7, Transient receptor potential cation channel subfamily M member 7, Channel-kinase 1, Long transient receptor potential channel 7

SwissProt ID

Q923J1 (Mouse), Q925B3 (Rat), Q96QT4 (Human)

Gene ID

54822 (TRPM7), 679906 (Trpm7), 58800

Available reactivities

Hu (Human), Can (Canine), Ms (Mouse), Por (Porcine), Rt (Rat)

Available hosts

Rabbit, Mouse, Goat

Available applications

Immunoprecipitation (IP), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Frozen Sections (C)

Background of TRPM7 antibody

Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient (1). They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces.
There are a few main classifications of gated ion channels. There are voltage- gated ion channels, ligand- gated, other gating systems and finally those that are classified differently, having more exotic characteristics. The first are voltage- gated ion channels which open and close in response to membrane potential. These are then separated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels; each of which is responsible for a unique role. Ligand-gated ion channels are also known as ionotropic receptors, and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein. The other gated classifications include activation and inactivation by second messengers, inward-rectifier potassium channels, calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels and cyclic nucleotide-gated channels. Finally, the other classifications are based on less normal characteristics such as two-pore channels, and transient receptor potential channels (2).
TRPs, mammalian homologs of the Drosophila transient receptor potential (trp) protein, are ion channels that are thought to mediate capacitative calcium entry into the cell. TRP-PLIK is a protein that is both an ion channel and a kinase. As a channel, it conducts calcium and monovalent cations to depolarize cells and increase intracellular calcium. As a kinase, it is capable of phosphorylating itself and other substrates. The kinase activity is necessary for channel function, as shown by its dependence on intracellular ATP and by the kinase mutants (3, 4).

General readings

1. Sun HS et.al. Suppression of hippocampal TRPM7 protein prevents delayed neuronal death in brain ischemia.
Nat Neurosci. 2009 Oct;12(10):1300-7. PMID: 19734892
2. Wei WL, Sun HS, Olah ME, Sun X, Czerwinska E, Czerwinski W, Mori Y, Orser BA, Xiong ZG, Jackson MF, Tymianski M, MacDonald JF. TRPM7 channels in hippocampal neurons detect levels of extracellular divalent cations. Proc Natl Acad Sci U S A. 2007 Oct 9;104(41):16323-8. PMID: 17913893
3. Kim BJ, Lim HH, Yang DK, Jun JY, Chang IY, Park CS, So I, Stanfield PR, Kim KW. Melastatin-type transient receptor potential channel 7 is required for intestinal pacemaking activity. Gastroenterology. 2005 Nov;129(5):1504-17. PMID: 16285951
4. He Y, Yao G, Savoia C, Touyz RM. Transient receptor potential melastatin 7 ion channels regulate magnesium homeostasis in vascular smooth muscle cells: role of angiotensin II. Circ Res. 2005 Feb 4;96(2):207-15.
PMID: 15591230

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

TRPM7 (C-term) antibody

TA302721 staining (1µg/ml) of Human Brain (hippocampus) lysate (RIPA buffer, 30µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence. Goat Aff - Purified Can, Hu, Ms, Por, Rt E, P
0.1 mg / €325.00
  OriGene Technologies, Inc.

TRPM7 antibody

IHC analysis of TrpM7 in human hippocampal tissues using TA309490. Mouse IgG1 S74-25 Purified Hu, Ms, Rt ICC/IF, IP, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

TRPM7 antibody

Predicted cell location: Cytoplasm . Positive control: Human colon and liver cancer tissue . Recommended dilution: 1/50-200  The image on the left is immunohistochemistry of paraffin-embedded human colon cancer tissue using TRPM7 antibody at dilution 1/30, on the right is treated with the synthetic peptide. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

TRPM7 antibody

Predicted cell location: Cytoplasm . Positive control: Human gastric and liver cancer tissue . Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded human gastric cancer tissue using TRPM7 antibody at dilution 1/25, on the right is treated with the synthetic peptide. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

TRPM7 antibody

Western blot analysis of GH3 cell line (lanes 1 and 2) and mouse brain (lanes 3 and 4) lysates: 1,3. Anti-TRPM7 antibody, (1:200). 2,4. Anti-TRPM7 antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

TRPM7 antibody

Immunoblot against adult rat brain membrane (RBM), rat liver membrane (RLM) and extracts of COS cells transiently
transfected with TrpM6, TrpM7 or Kv2.1 plasmid probed with N74/25 (left) or a loading control (right) TC supe. Mouse IgG1 N74/25 Supernatant Hu, Ms, Rt ICC/IF, IP, WB
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

TRPM7 antibody

Immunoblot against adult rat brain membrane (RBM), rat liver membrane (RLM) and extracts of COS cells transiently
transfected with TrpM6, TrpM7 or Kv2.1 plasmid probed with N74/25 (left) or a loading control (right) TC supe. Mouse IgG1 N74/25 Purified Hu, Ms, Rt ICC/IF, IP, WB
0.1 ml / €380.00
  Antibodies Incorporated

NeuroMab

TRPM7 (N-term) antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Rabbit Ig Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

TRPM7 (C-term) antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Rabbit Ig Purified Hu P, WB

Regular Price: 0.4 ml / €370.00

Special Price: 0.4 ml / €231.00

  Acris Antibodies GmbH

TRPM7 (C-term) antibody

TA302721 staining (1µg/ml) of Human Brain (hippocampus) lysate (RIPA buffer, 30µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence. Goat Aff - Purified Can, Hu, Ms, Por, Rt E, P
20 µg / €200.00
  Acris Antibodies GmbH

TRPM7 antibody

TRPM7 Rabbit Serum Ms C, E, WB
0.2 ml / €400.00
  Acris Antibodies GmbH

TRPM7 antibody

TRPM7 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

TRPM7 antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with TRPM7 polyclonal antibody ( Cat # PAB3249 ) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma. Rabbit Hu E, P, WB
0.4 ml / €390.00
  Abnova Taiwan Corp.

TRPM7 antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with TRPM7 polyclonal antibody ( Cat # PAB3250 ) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. HC = hepatocarcinoma. Rabbit Hu E, P
0.4 ml / €390.00
  Abnova Taiwan Corp.

TRPM7 antibody

TRPM7 Rabbit Hu IP, WB
0.1 ml / €470.00
  Abnova Taiwan Corp.

TRPM7 (C-term) antibody

TRPM7 Rabbit Aff - Purified Hu, Ms ELISA
25 µg / €630.00
  Funakoshi Co., Ltd.

TRPM7 antibody

Western Blot:TRPM7 Antibody [NB100-810]- (0.5ug/ml) staining of Human Cerebellum lysate (35ug protein in RIPA buffer). Goat IgG Aff - Purified Ms E, P, WB
0.1 mg / €400.00
  Novus Biologicals Inc.

TRPM7 antibody

TRPM7 Rabbit Serum Hu IP, WB
0.1 ml / €360.00
  Novus Biologicals Inc.

TRPM7 Control Peptide

TRPM7
50 µg / €140.00
  Novus Biologicals Inc.

TRPM7 antibody

TRPM7 Rabbit Hu IP, WB
25 µl / €160.00
  Novus Biologicals Inc.

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