TRPM8 antibody

Principal name

TRPM8 antibody

Alternative names for TRPM8 antibody

TRPP8, Trp-p8, LTRPC6, Transient receptor potential cation channel subfamily M member 8, Transient receptor potential-p8, Long transient receptor potential channel 6

SwissProt ID

Q7Z2W7 (Human), Q8R455 (Rat), Q8R4D5 (Mouse)

Gene ID

79054 (TRPM8), 171384 (Trpm8)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Chk (Chicken), Rb (Rabbit), Dros (Drosophila), Eq (Equine), GP (Guinea Pig), Por (Porcine), Mky (Monkey), Xen (Xenopus)

Available hosts

Rabbit, Sheep, Mouse, Goat

Available applications

Western blot / Immunoblot (WB), Frozen Sections (C), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P)

Background of TRPM8 antibody

Dorsal root ganglion (DRG) are receptive of environmental stimuli such as temperature and pressure by molecular markers, for temperature the DRG neurons have thermo transient potential receptors (TRPs) are members of the transient receptor potential family of ion channels and are gated by shifts in temperature. TRPM8 is activated by cooling, and TRPM8-deficient mice have severe deficits in cool thermosensation (1). The ion channels carrying the stimulus-activated receptor current in sensory neurons have been identified and the mechanism of their activation elucidated, for a variety of sensory systems and for species ranging from worms and flies to humans. In physiological terms the Transient Receptor channels should be a non-selective cation channel that is permeable to all the alkali cations and to many divalent cations. The channel has a particularly high calcium permeability, passing Ca2+ at least 10 times better than Na+ at the same time, Ca2+ in millimolar concentrations acts as a partial blocker, inhibiting current by monovalent ions. Most eukaryotic genomes include a substantial repeat-rich fraction termed heterochromatin, which is concentrated in centric and telomeric regions. The repetitive nature of heterochromatic sequence makes it difficult to assemble and analyze. To better understand the heterochromatic component of the Drosophila melanogaster genome, the entire transposable region was annotated for a whole-genome shotgun sequence assembly. The shot gun sequence assembly analyses predicted 297 protein-coding genes and six non-protein-coding genes, including known heterochromatic genes, and regions of similarity to known transposable elements (1). One of these genes code for a protein called transient receptor potential (Trp). The transient receptor potential gene is referred to in FlyBase by the symbol trp (CG7875, FBgn0003861). It has the cytological map location 99C6-99C7. Its sequence location is 3R:25740242: 25746011. There are at least one more subtype is known to exist as TrpA1.
Trpm8 is a 1104 amino acid protein, containing 8 TMDs and is a calcium ion channel component; its function is described in modulation of calcium channel activity. It also regulates calcium calmodulin and intracellular ligand-gated calcium channel and store-operated calcium channels. The physiological functions associated with Trp include modulation in the light activated voltage-gated channel activity, calcium ion transport in response to light stimulus and in light induced release of cytosolic sequestered calcium ion. Physiologically, trp involvement is also studied in calcium-mediated signaling; phototransduction; phospholipase C inhibition. There are 29 alleles are reported in literature, the phenotypes of these alleles are annotated with: photoreceptor; photoreceptor cell; antenna; rhabdomere; ommatidium; retina. It has one annotated transcript and one annotated polypeptide. Trp undergoes phosphorylation for activation at position. There are number of human homolog for the fly Trp channels including TRPN1, TRPV4, TRPML3 and TRPA1 (2).

General readings

Tsavaler L., et al. Cancer Res. 61(9):3760-9, 2001.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

TRPM8 (Center) antibody

Western blot analysis of TRPM8 (arrow) using rabbit polyclonal TRPM8 Antibody (Center R536)(Cat.#TA302225).293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the TRPM8 gene (Lane 2) (Origene Technologies). Rabbit Ig Purified Hu P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

TRPM8 antibody

Western blot analysis of prostate carcinoma cell lines; DU145 (lanes 1,3), LNCaP (lanes 2,4) and mouse-TRPM8 transfected HEK-293 (lanes 5,6) cell lysates : 1,2,5. Anti-TRPM8 (extracellular) antibody, (1:200). 3,4,6. Anti-TRPM8 (extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

TRPM8 (C-term) antibody

Western blot analysis of TRPM8 (arrow) using rabbit polyclonal TRPM8 Antibody (C-term C940)(Cat.#TA302224).293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the TRPM8 gene (Lane 2) (Origene Technologies). Rabbit Ig Purified Hu P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

TRPM8 (C-term) antibody

Western blot analysis of TRPM8 (arrow) using rabbit polyclonal TRPM8 Antibody (C-term)(Cat.#TA302226).293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the TRPM8 gene (Lane 2) (Origene Technologies). Rabbit Ig Purified Hu P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

TRPM8 (Center) antibody

Western blot analysis of lysate from LNCaP cell line,using TRPM8 Antibody (Center)(Cat. #TA324432).TA324432 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody.Lysate at 35ug per lane. Rabbit Ig Purified Hu ICC/IF, P, WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

TRPM8 antibody

Western Blot: TRPM8 Antibody [TA336589] - Analysis of TRPM8 in transfected COS cells using TA336589 at 1:750 and incubated overnight at 4C. Secondary rabbit HRP antibody was incubated 1 hour at RT followed by ECL detection. Rabbit Purified Dros, Hu, Ms C, E, ICC/IF, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

TRPM8 antibody

Western Blot: TRPM8 Antibody [TA336867] - WB analysis of TRPM8 in PC12 cell lysate. Rabbit Purified Hu, Ms, Rt C, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TRPM8 antibody

WB Suggested Anti-TRPM8 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:312500; Positive Control: ACHN cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

TRPM8 antibody

Anti-TRPM8 antibody IHC of human Pancreas, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Purified Bov, Can, Hu, Por, Rb
50 µg / €379.00
  OriGene Technologies, Inc.

TRPM8 antibody

Anti-TRPM8 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Purified Bov, Hu, Mky, Por, Xen
50 µg / €379.00
  OriGene Technologies, Inc.

TRPM8 antibody

Anti-TRPM8 antibody IHC of human lung, vessel. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Purified Eq, Hu, Ms, Por, Rt
50 µg / €379.00
  OriGene Technologies, Inc.

TRPM8 Control Peptide

TRPM8
0.1 mg / €250.00
  Acris Antibodies GmbH

TRPM8 antibody

TRPM8 Rabbit IgG Aff - Purified Ms, Rt E, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

TRPM8 antibody

TRPM8 Rabbit Purified
0.1 mg / €420.00
  Acris Antibodies GmbH

TRPM8 antibody

TRPM8 Rabbit Serum Hu C, E, WB
0.2 ml / €400.00
  Acris Antibodies GmbH

TRPM8 (N-term) antibody

TRPM8 Antibody (N-term) (AP54365PU-N)immunohistochemistry analysis in formalin fixed and paraffin embedded human prostate carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of TRPM8 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated. Rabbit Ig Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

TRPM8 antibody

TRPM8 Mouse Hu WB
0.5 mg / €1,400.00
  Abnova Taiwan Corp.

TRPM8 antibody

Western blot analysis of TRPM8 ( arrow ) using rabbit TRPM8 polyclonal antibody ( Cat # PAB4071 ) . 293 cell lysate ( 2 µg/lane ) either nontransfected ( Lane 1 ) or transiently transfected with the TRPM8 gene ( Lane 2 ) ( Origene Technologies ) . Rabbit Hu C, E, WB
0.4 ml / €390.00
  Abnova Taiwan Corp.

TRPM8 antibody

Formalin-fixed and paraffin-embedded human prostata carcinoma tissue reacted with TRPM8 polyclonal antibody ( Cat # PAB4072 ) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Hu E, P, WB
0.4 ml / €390.00
  Abnova Taiwan Corp.

TRPM8 antibody

Western blot analysis of TRPM8 ( arrow ) using rabbit TRPM8 polyclonal antibody ( Cat # PAB4073 ) . 293 cell lysate ( 2 µg/lane ) either nontransfected ( Lane 1 ) or transiently transfected with the TRPM8 gene ( Lane 2 ) ( Origene Technologies ) . Rabbit Hu E, WB
0.4 ml / €390.00
  Abnova Taiwan Corp.

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