TRPV3 / Vanilloid receptor-like 3 antibody

Principal name

TRPV3 / Vanilloid receptor-like 3 antibody

Alternative names for TRPV3 / Vanilloid receptor-like 3 antibody

VRL-3, Transient receptor potential cation channel subfamily V member 3

SwissProt ID

Q8NET8 (Human)

Gene ID

162514 (TRPV3)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Can (Canine)

Available hosts

Sheep, Goat, Rabbit, Mouse

Available applications

Frozen Sections (C), Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P)

Background of TRPV3 / Vanilloid receptor-like 3 antibody

TRP channels are a large family (about 28 genes) of plasma membrane, non-selective cationic channels that are either specifically or ubiquitously expressed in excitable and non-excitable cells. The TRP channels have six putative transmembrane domains (TM) with a pore domain between the fifth and the sixth TM, and all assemble as tetramers. Both the N- and the C-terminus of all TRPs are intracellular. According to IUPHAR, the TRP family is composed of three main subfamilies on the basis of sequence homology; TRPC, TRPM and TRPV (to date, three additiol subfamilies are also considered to belong to the TRP family: the TRPA, TRPML, and TRPP). The TRPV subfamily consists of six members, TRPV1-6. Four members of the TRPV family have been described as a thermosensitive ion channels (TRPV1 to TRPV4). Each channel exhibits distinct thermal activation thresholds ranging from noxious cold (<17°C) to noxious heat (>52°C). TRPV3 is highly expressed in skin keratinocytes. It forms a nonselective cation channel that is activated by hot temperatures in the innocuous and noxious range. The channel is also expressed in oral and sal cavities where it has been postulated to play a role in flavor sensation. TRPV3 is also implicated as a molecular target of some allergens and skin sensitizers.

General readings

1. Xu H, Ramsey IS, Kotecha SA, Moran MM, Chong JA, Lawson D, Ge P, Lilly J, Silos-Santiago I, Xie Y, DiStefano PS, Curtis R, Clapham DE. TRPV3 is a calcium-permeable temperature-sensitive cation channel. Nature. 2002 Jul 11;418(6894):181-6. Epub 2002 Jun 23
PMID: 12077604

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

TRPV3 / Vanilloid receptor-like 3 (762-773) antibody

  Goat Anti-TRPV3 (aa762-773) Antibody  
HEK293 lysate (10ug protein in RIPA buffer) overexpressing Human TRPV3 with DDK (FLAG) tag probed with TA311578 (0.5ug/ml) in Lane A and probed with anti-DDK Tag (1:10,000, Cat# TA50011-100) in Lane C. Mock-transfected HEK293 probed with TA311578 (1mg/ml) in Lane B. Primary incubations were for 1 hour. Detected by chemiluminescence. Goat Aff - Purified Can, Hu, Ms, Rt E, WB
0.1 mg / €360.00
  OriGene Technologies, Inc.

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