Trypsin-1 / PRSS1 antibody

Principal name

Trypsin-1 / PRSS1 antibody

Alternative names for Trypsin-1 / PRSS1 antibody

TRP1, TRY1, TRYP1, Trypsin I, Cationic trypsinogen, Beta-trypsin, Serine protease 1

SwissProt ID

P00760 (Bovin), P00761, P00762 (Rat), P06871 (Canfa), P07477 (Human), P19799 (Xenla), Q90627 (Chick)

Gene ID

5644 (PRSS1), 615026 (LOC615026), 24691 (Prss1)

Available reactivities

Hu (Human), Bov (Bovine), Ms (Mouse), Rt (Rat), Can (Canine), Eq (Equine), Por (Porcine), Rb (Rabbit), Ze (Zebrafish)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Immunodiffusion (ID), Immunoprecipitation (IP), Dot blot (Dot), Immunocytochemistry/Immunofluorescence (ICC/IF), Radioimmunoassay (R), Paraffin Sections (P), ELISA (capture) (E(capture)), Frozen Sections (C)

Background of Trypsin-1 / PRSS1 antibody

The human pancreas secretes three different isoforms of the inactive trypsinogen into the small intestine, namely cationic trypsinogen, anionic trypsinogen (the two major isoforms) and mesotrypsinogen (a minor isoform). In the small intestine, each isoform is cleaved by Enterokinase into its active form, Trypsin-1, Trypsin-2 and Trypsin-3, respectively. All trypsins are members of the serine protease trypsin family. The activated trypsins go on to activate other protease zymogens and play a role in the autoactivation of trypsinogens. This suggests an important role for trypsins in digestion. Mutations in the gene encoding Trypsin-1 that stimulate its activity are associated with autosomal dominant hereditary pancreatitis (HCP), also known as chronic pancreatitis (CP), a disease characterized by persistent, severe abdominal pain due to calcifications of the parenchyma, pancreatic stones, cysts and pancreatic head enlargement. Trypsin-3, also known as Trypsin-4, is expressed in the brain in addition to the pancreas.

General readings

Joergensen, M.T., et al. Am. J. Gastroenterol. 105(8):1876-1883 (2010)
Gasiorowska, A., et al. Dig. Dis. Sci. (2010)
Szmola, R., et al. J. Med. Genet. 47(5):348-350 (2010)
Nakanuma, S., et al. Int. J. Oncol. 36(4):793-800 (2010)
Johansen, D., et al. Pancreatology 10 (2-3), 229-237 (2010)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Trypsin antibody

Pancreas, Human: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG2b Purified Hu E, P
50 µg / €425.00
  OriGene Technologies GmbH

Trypsin (immunoreactive) antibody

Trypsin Mouse IgG 2C4 Purified Hu E, E(detection)
1 mg / €400.00
  HyTest Ltd.

Trypsin (immunoreactive) antibody

Trypsin Mouse IgG 4A7 Purified Hu E, E(capture)
1 mg / €400.00
  HyTest Ltd.

Trypsin (immunoreactive) antibody

Trypsin Mouse IgG 5B1 Purified Hu E, E(detection)
1 mg / €400.00
  HyTest Ltd.

Trypsin-1 / PRSS1 antibody

  Anti-PRSS1 Rabbit Polyclonal Antibody  
Predicted band size: 27 kDa . Positive control: Liver tissue lysate. Recommended dilution: 1/500-2000. (Gel: 10%SDS-PAGE Lysate: 40 ug Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute) Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €335.00
  OriGene Technologies, Inc.

Trypsin-1 / PRSS1 antibody

  Rabbit Polyclonal Anti-PRSS1 Antibody  
WB Suggested Anti-PRSS1 Antibody; Titration: 1.0 ug/ml; Positive Control: Jurkat Whole Cell Rabbit IgG Purified Bov, Can, Eq, Hu, Ms, Por, Rb, Rt, Ze WB
0.1 ml / €360.00
  OriGene Technologies, Inc.

Trypsin-1 / PRSS1 antibody

Trypsin-1 / PRSS1 Mouse IgG2b 403 Purified Hu E
0.2 mg / €470.00
  OriGene Technologies GmbH

Trypsin-1 / PRSS1 antibody

Trypsin-1 / PRSS1 Mouse IgG2b 404 Purified Hu E
0.2 mg / €470.00
  OriGene Technologies GmbH

Trypsin-1 / PRSS1 antibody

Trypsin-1 / PRSS1 Rabbit Purified Hu E, ID, WB
1 ml / €510.00
  OriGene Technologies GmbH

Trypsin-1 / PRSS1 antibody

Trypsin-1 / PRSS1 Rabbit IgG Azide Free Bov Dot, E, ICC/IF, ID, R, WB
10 mg / €230.00
  OriGene Technologies GmbH

Trypsin-1 / PRSS1 antibody

Trypsin-1 / PRSS1 Rabbit IgG Biotin Bov Dot, E, ICC/IF, ID, IP, R, WB
1 ml / €390.00
  OriGene Technologies GmbH

Trypsin-1 / PRSS1 antibody

Trypsin-1 / PRSS1 Rabbit IgG Aff - Purified Bov Dot, E, ICC/IF, ID, IP, R, WB
1 mg / €530.00
  OriGene Technologies GmbH

Trypsin-1 / PRSS1 (Center) antibody

Western blot analysis in NCI-H460 cell line lysates (35ug/lane) using Trypsin-1 / PRSS1 antibody Cat.-No. AP53464PU-N. This demonstrates the PRSS1 antibody detected the PRSS1 protein (arrow). Rabbit Ig Aff - Purified Hu WB
0.4 ml / €415.00
  OriGene Technologies GmbH

Trypsin-1 / PRSS1 antibody

Trypsin-1 / PRSS1 Mouse IgG2b 401 Azide Free Hu E
0.2 mg / €480.00
  OriGene Technologies GmbH

Trypsin-1 / PRSS1 antibody

Trypsin-1 / PRSS1 Rabbit Serum Bov E, WB
2 ml / €1,345.00
  OriGene Technologies GmbH

Trypsin-1 / PRSS1 antibody

Trypsin-1 / PRSS1 Rabbit HRP Bov C, E, P, WB
0.1 mg / €515.00
  OriGene Technologies GmbH

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Trypsin-1 / PRSS1

Trypsin-1 / PRSS1 Human Purified > 95 % pure by SDS-PAGE. Pancreas
0.1 mg / €530.00
  OriGene Technologies GmbH

Lysates

Catalog No.    

PRSS1 overexpression lysate

PRSS1 overexpression lysate  
0.1 mg / €295.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, PRSS1 (mGFP-tagged) - Human protease, serine, 1 (trypsin 1) (PRSS1), 200 uL, >10^7 TU/mL

Lenti ORF particles, PRSS1 (mGFP-tagged) - Human protease, serine, 1 (trypsin 1) (PRSS1), 200 uL, >10^7 TU/mL  
200 µl / €930.00
  OriGene Technologies, Inc.

Lenti ORF particles, PRSS1 (Myc-DDK tagged) - Human protease, serine, 1 (trypsin 1) (PRSS1) , 200 uL, >10^7 TU/mL

Lenti ORF particles, PRSS1 (Myc-DDK tagged) - Human protease, serine, 1 (trypsin 1) (PRSS1) , 200 uL, >10^7 TU/mL  
200 µl / €830.00
  OriGene Technologies, Inc.

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