Tryptophan 5-hydroxylase 1 (TPH1) antibody

Principal name

Tryptophan 5-hydroxylase 1 (TPH1) antibody

Alternative names for Tryptophan 5-hydroxylase 1 (TPH1) antibody

Tryptophan 5-monooxygenase 1, TPRH, TRPH

SwissProt ID

P09810 (Rat), P17290 (Rabit), P17532 (Mouse), P17752 (Human), P70080 (Chick)

Gene ID

7166 (TPH1), 100009100 (TPH2), 24848 (Tph1), 100101558

Available reactivities

Hu (Human), Rt (Rat), Rb (Rabbit), Ms (Mouse), Bov (Bovine), Can (Canine), Mky (Monkey), Xen (Xenopus), Ze (Zebrafish), Chk (Chicken)

Available hosts

Rabbit, Sheep, Mouse

Available applications

Frozen Sections (C), Paraffin Sections (P), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Flow Cytometry (F), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), ELISA (detection) (E(detection))

Background of Tryptophan 5-hydroxylase 1 (TPH1) antibody

Phenylalanine hydroxylase (PAH), tyrosine hydroxylase (TH) and tryptophan hydroxylase (TPH) comprise a small family of monooxygenases that use tetrahydropterine as a cofactor during the catabolism of aromatic L-amino acids. PAH, TH and TPH all contain catalytic domains with an amino-terminal regulatory domain and a short carboxy-terminal tetramerization domain. Each of these enzymes also contains a single ferrous iron atom, which is bound to two histidines and a glutamate, and is likely to be involved in the formation of the hydroxylating intermediate. TPH is both the first- and rate-limiting-step in the biosynthesis of serotonin in the central nervous system and melatonin in the pineal gland. Alteration of TPH function may be a key factor in the pathology of several neuropsychiatric disorders associated with serotonin, including depression, aggression, alcoholism and schizophrenia. For instance, L-DOPA, which is used as a common therapy for Parkinson’s disease (PD) patients, inhibits TPH function which, subsequently, is thought to contribute to the onset of depression in PD patients.

General readings

1. Jiang GC, Yohrling GJ, Schmitt JD, Vrana KE (2000) Identification of substrate orienting and phosphorylation sites
within tryptophan hydroxylase using homology-based molecular modeling. J Mol Biol 302:1005-1017.
2. Johansen PA, Jennings I, Cotton RG, Kuhn DM (1996) Phosphorylation and activation of tryptophan hydroxylase by
exogenous protein kinase A. J Neurochem 66:817-823.
3. Martinez A, Knappskog PM, Haavik J (2001) Structural approach into human tryptophan hydroxylase and its implications for the regulation of serotonin biosynthesis. Curr Med Chem 8:1077-1091.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Tryptophan 5-hydroxylase 1 (TPH1) antibody

Western blot of human dorsal Raphe nucleus showing specifc immunolabeling of the ~55k tryptophan hydroxylase protein. Sheep IgG Aff - Purified Hu, Rt C, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Tryptophan 5-hydroxylase 1 (TPH1) antibody

Western blot analysis of extracts from HepG2 cells, using Tryptophan Hydroxylase (Ab-58) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Tryptophan 5-hydroxylase 1 (TPH1) antibody

Predicted cell location: Cytoplasm. Positive control: Human thyroid and gastric cancer tissue. Recommended dilution: 1/15-50  The image on the left is immunohistochemistry of paraffin-embedded human thyroid cancer tissue using TPH1 antibody at dilution 1/20, on the right is treated with the fusion protein. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Tryptophan 5-hydroxylase 1 (TPH1) antibody

Predicted cell location: Cytoplasm. Positive control: Human thyroid and lung cancer tissue. Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded human thyroid cancer tissue using TPH1 antibody at dilution 1/25, on the right is treated with the fusion protein. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Tryptophan 5-hydroxylase 1 (TPH1) antibody

Tryptophan 5-hydroxylase 1 (TPH1) Mouse IgG3 Try-63 Purified Hu, Rb, Rt WB
0.1 mg / €340.00
  Acris Antibodies GmbH

Tryptophan 5-hydroxylase 1 (TPH1) pSer58 antibody

Tryptophan 5-hydroxylase 1 (TPH1) Rabbit IgG Purified Bov, Can, Hu, Mky, Ms, Rb, Rt, Xen, Ze WB
0.1 ml / €510.00
  Acris Antibodies GmbH

Tryptophan 5-hydroxylase 1 (TPH1) antibody

Tryptophan 5-hydroxylase 1 (TPH1) Sheep IgG Purified Hu, Rt C, WB
0.1 ml / €510.00
  Acris Antibodies GmbH

Tryptophan 5-hydroxylase 1 (TPH1) pSer58 antibody

Figure 1. Western blot of recombinant Tryptophan Hydroxylase incubated in the absence (Control) and presence of cAMP-dependent protein kinase (PKA) showing specific immunolabeling of the ~53k Tryptophan Hydroxylase protein phosphorylated at Ser58. Rabbit IgG Aff - Purified Bov, Chk, Hu, Ms, Rb, Rt, Xen, Ze C, WB
0.1 ml / €380.00
  Acris Antibodies GmbH

Tryptophan 5-hydroxylase 1 (TPH1) pSer260 antibody

Figure 1. Western blot of Rat brainstem lysate showing specific immunolabeling of the ~55k TPH protein phosphorylated at Ser260. The labeling is specifically blocked by the  phosphopeptide (Phos-pep) used as antigen. The corresponding non-phosphopeptide (Nonphos-pep) did not block the immunolabeling. Rabbit IgG Aff - Purified Bov, Can, Chk, Hu, Ms, Rt, Ze WB
0.1 ml / €380.00
  Acris Antibodies GmbH

Tryptophan 5-hydroxylase 1 (TPH1) (N-term) antibody

Western blot analysis of TPH1 Antibody (N-term) (AP17802PU-N) in 293 cell line lysates (35ug/lane). TPH1 (arrow) was detected using the purified Pab. Rabbit Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Tryptophan 5-hydroxylase 1 (TPH1) antibody

Immunohistochemistry analyzes of TPH1 antibody (Cat.-No.: AP20275PU-N) in paraffin-embedded human brain tissue. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

Tryptophan 5-hydroxylase 1 (TPH1) antibody

Immunohistochemistry (IHC) analyzes of TPH1 antibody (Cat.-No.: AP21097PU-N) in paraffin-embedded human lung carcinoma tissue. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

Tryptophan 5-hydroxylase 1 (TPH1) antibody

Tryptophan 5-hydroxylase 1 (TPH1) Sheep Purified Hu, Rb, Rt C, WB
25 µl / €440.00
  Acris Antibodies GmbH

Tryptophan 5-hydroxylase 1 (TPH1) antibody

Tryptophan 5-hydroxylase 1 (TPH1) Mouse Serum Hu E
50 µl / €290.00
  Abnova Taiwan Corp.

Tryptophan 5-hydroxylase 1 (TPH1) antibody

Tryptophan 5-hydroxylase 1 (TPH1) Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

Tryptophan 5-hydroxylase 1 (TPH1) pSer58 antibody

Western blot of recombinant tryptophan hydroxylase incubated in the absence (Control) and presence of cAMP-dependent protein kinase (PKA) showing specific immunolabeling of the ~53k TPH1 protein phosphorylated at Ser58. Rabbit Bov, Hu, Ms, Rb, Rt WB
0.1 ml / €510.00
  Abnova Taiwan Corp.

Tryptophan 5-hydroxylase 1 (TPH1) pSer58 antibody

Immunohistochemistry analysis of paraffin-embedded human brain, using Tryptophan Hydroxylase (Phospho-Ser58) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
50 µg / €205.00
  Assay Biotech

Tryptophan 5-hydroxylase 1 (TPH1) pSer58 antibody

Immunohistochemistry analysis of paraffin-embedded human brain, using Tryptophan Hydroxylase (Phospho-Ser58) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €310.00
  Assay Biotech

Tryptophan 5-hydroxylase 1 (TPH1) pSer260 antibody

Immunohistochemistry analysis of paraffin-embedded human lung carcinoma, using Tryptophan Hydroxylase (Phospho-Ser260) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
50 µg / €205.00
  Assay Biotech

Tryptophan 5-hydroxylase 1 (TPH1) pSer260 antibody

Immunohistochemistry analysis of paraffin-embedded human lung carcinoma, using Tryptophan Hydroxylase (Phospho-Ser260) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €310.00
  Assay Biotech

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