Tryptophan 5-hydroxylase 2 (TPH2) antibody

Principal name

Tryptophan 5-hydroxylase 2 (TPH2) antibody

Alternative names for Tryptophan 5-hydroxylase 2 (TPH2) antibody

Tryptophan 5-monooxygenase 2, Neuronal tryptophan hydroxylase, NTPH

SwissProt ID

Q0EAB8 (Horse), Q8CGU9 (Rat), Q8CGV2 (Mouse), Q8IWU9 (Human)

Gene ID

121278 (TPH2), 317675 (Tph2), 25085 (Th), 1121278 (glpD)

Available reactivities

Bov (Bovine), Can (Canine), Chk (Chicken), Hu (Human), Ms (Mouse), Rt (Rat), Ze (Zebrafish), Rb (Rabbit), Mky (Monkey), Por (Porcine), Eq (Equine)

Available hosts

Rabbit, Goat, Mouse

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Flow Cytometry (F)

Background of Tryptophan 5-hydroxylase 2 (TPH2) antibody

Tryptophan hydroxylase (TPH; EC 1.14.16.4) is the rate-limiting enzyme in the synthesis of serotonin (5-hydroxytryptamine, or 5HT). 5HT is causally involved in numerous central nervous activities, and it has several functions in peripheral tissues, including the maintence of vascular tone and gut motility. This gene encodes a member of the pterin-dependent aromatic acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. The human genome contains two related tryptophan hydroxylases, one on chromosome 11p15-p14 and one on chromosome 12q21. This gene is expressed predomintly in the brain stem. Mutations in this gene may be associated with psychiatric diseases such as bipolar affective disorder and major depression. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by the mouse ortholog. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additiol publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-1805 AY098914.1 1-1805 1806-2360 AC090109.15 122981-123535

General readings

Zhou Z, Roy A, Lipsky R, Kuchipudi K, Zhu G, Taubman J, Enoch MA, Virkkunen M, Goldman D. Haplotype-based linkage of tryptophan hydroxylase 2 to suicide attempt, major depression, and cerebrospinal fluid 5-hydroxyindoleacetic acid in 4 populations. Arch Gen Psychiatry. 2005 Oct;62(10):1109-18. PMID: 16203956

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Tryptophan 5-hydroxylase 2 (TPH2) pSer19 antibody

Figure 1. Western blot of recombinant Tryptophan Hydroxylase incubated in the absence (Control) and presence of  Ca2+/calmodulin dependent kinase II (CaMKII) showing specific immunolabeling of the ~55k tryptophan hydroxylase protein phosphorylated at Ser19. Rabbit IgG Aff - Purified Bov, Ms, Rt, Ze WB
0.1 ml / €380.00
  Acris Antibodies GmbH

Tryptophan 5-hydroxylase 2 (TPH2) (16-29) antibody

(0.5ug/ml) staining of HEK293 lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Bov, Can, Hu, Ms, Por, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Tryptophan 5-hydroxylase 2 (TPH2) antibody

Western blot analysis of extracts from HeLa, Cos7 and 293 cells, using TPH2 (Ab-19) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Tryptophan 5-hydroxylase 2 (TPH2) (Center) antibody

Western blot analysis of TPH2 Antibody (Center) (Cat. #TA325096) in 293 cell line lysates (35ug/lane). TPH2 (arrow) was detected using the purified Pab. Rabbit Ig Aff - Purified Hu F, P, WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

Tryptophan 5-hydroxylase 2 (TPH2) antibody

WB Suggested Anti-TPH2 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:500; Positive Control: Human brain Rabbit IgG Purified Bov, Can, Hu, Por, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

Tryptophan 5-hydroxylase 2 (TPH2) antibody

WB Suggested Anti-TPH2 Antibody Titration: 0.2-1 ug/ml; Positive Control: HepG2 cell lysate Rabbit IgG Purified Bov, Can, Eq, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

Tryptophan 5-hydroxylase 2 (TPH2) antibody

Western Blot: Tryptophan hydroxylase 2 Antibody [TA336835] - WB analysis of TPHZ in human stomach lysate. Rabbit Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Tryptophan 5-hydroxylase 2 (TPH2) antibody

Western Blot: Tryptophan hydroxylase 2 Antibody [TA336836] - WB analysis of TPH2 in human stomach lysate. Rabbit Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Tryptophan 5-hydroxylase 2 (TPH2) pSer19 antibody

Tryptophan 5-hydroxylase 2 (TPH2) Rabbit IgG Purified Bov, Ms, Rt, Ze WB
0.1 ml / €510.00
  Acris Antibodies GmbH

Tryptophan 5-hydroxylase 2 (TPH2) antibody

AP23653PU-N TPH2 antibody staining of Paraffin Embedded Human Brain Stem at 4 µg/ml. Steamed antigen retrieval with citrate buffer pH 6, HRP-staining. Goat Aff - Purified Can, Hu E, P
0.1 mg / €340.00
  Acris Antibodies GmbH

Tryptophan 5-hydroxylase 2 (TPH2) antibody

AP33143PU-N (0.5 µg/ml) staining of paraffin embedded Mouse Brain stem in sagittal (left) and coronal (right) sections of Raphe nuclei. Detection Alexa 594. Data obtained from Prof. D Crane, Griffith Univeristy, Brisbane, Australia. Goat Aff - Purified Ms P
0.1 mg / €340.00
  Acris Antibodies GmbH

Tryptophan 5-hydroxylase 2 (TPH2) antibody

Tryptophan 5-hydroxylase 2 (TPH2) Goat Hu E
0.1 mg / €400.00
  Abnova Taiwan Corp.

Tryptophan 5-hydroxylase 2 (TPH2) antibody

Western blot of recombinant tryptophan hydroxylase incubated in the absence (Control, lane 1) and presence of Ca2+/calmodulin dependent kinase II (CaMKII, lane 2) showing specific immunolabeling of the ~55k Tph2 protein phosphorylated at Ser19. Rabbit Bov, Ms, Rt WB
0.1 ml / €510.00
  Abnova Taiwan Corp.

Tryptophan 5-hydroxylase 2 (TPH2) antibody

Human Brain; WB Suggested Anti-TPH2 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:500. Positive Control: Human brain; TPH2 antibody - middle region (ARP34140_P050) in Human Brain cells using Western Blot Rabbit Aff - Purified Bov, Can, Chk, Hu, Ms, Rt, Ze WB
50 µg / €350.00
  AVIVA Systems Biology

Tryptophan 5-hydroxylase 2 (TPH2) antibody

Human HepG2; WB Suggested Anti-TPH2 Antibody Titration: 0.2-1 ug/ml. Positive Control: HepG2 cell lysate; TPH2 antibody - N-terminal region (ARP34141_P050) in Human HepG2 cells using Western Blot Rabbit Aff - Purified Bov, Can, Chk, Hu, Ms, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

Tryptophan 5-hydroxylase 2 (TPH2) antibody

Tryptophan 5-hydroxylase 2 (TPH2) Goat IgG Aff - Purified Hu E, P
0.1 mg / €320.00
  Novus Biologicals Inc.

Tryptophan 5-hydroxylase 2 (TPH2) pSer19 antibody

Tryptophan 5-hydroxylase 2 (TPH2) Rabbit IgG Aff - Purified Rt WB
50 µl / €400.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Tryptophan 5-hydroxylase 2 (TPH2)

Tryptophan 5-hydroxylase 2 (TPH2) Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

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